<i>Helicobacter pylori</i> and Extragastric Diseases

Franceschi, Francesco; Tortora, Annalisa; Gasbarrini, Giovanni; Gasbarrini, Antonio

doi:10.1111/hel.12159

Cited by 127 publications

(42 citation statements)

References 77 publications

(122 reference statements)

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“…The bacteria have been proposed to cause a variety of extra-gastric diseases and metabolic derangements, either directly, through molecular mimicry, or indirectly, by producing chronic inflammation 65-67 . The H pylori -related disease peptic ulcer has long been associated with an increased risk for cardiovascular disease 68 .…”

Section: Is the Only Good H Pylori A Dead H Pylori?mentioning

confidence: 99%

Helicobacter pylori Update: Gastric Cancer, Reliable Therapy, and Possible Benefits

2015

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Helicobacter pylori infection contributes to development of diverse gastric and extra-gastric diseases. The infection is necessary but not sufficient for development of gastric adenocarcinoma. Its eradication would eliminate a major worldwide cause of cancer death, so there is much interest in identifying how, if, and when this can be accomplished. There are several mechanisms by which H pylori contributes to development of gastric cancer. Gastric adenocarcinoma is one of many cancers associated with inflammation, which is induced by H pylori infection, yet the bacteria also cause genetic and epigenetic changes that lead to genetic instability in gastric epithelial cells. H pylori eradication reduces both. However, many factors must be considered in determining whether treating this bacterial infection will prevent cancer or only reduce its risk—these must be considered in designing reliable and effective eradication therapies. Furthermore, H pylori infection has been proposed to provide some benefits, such as reducing the risks of obesity or childhood asthma, although there are no convincing data to support the benefits of H pylori infections.

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Section: Is the Only Good H Pylori A Dead H Pylori?mentioning

confidence: 99%

Helicobacter pylori Update: Gastric Cancer, Reliable Therapy, and Possible Benefits

2015

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“…There is a very strong interest of researchers from all over the world in the extragastric manifestations of Helicobacter pylori infection, as demonstrated by the high number of studies published in this field during the last year. Indeed, H. pylori is a very good model for studying host–bacterial interactions and very attractive for those interested in the role of gut microbiota in health and disease . Here, we shall summarize the results of the most relevant studies published on this topic from May 2014 to May 2015.…”

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confidence: 99%

Extragastric Diseases and Helicobacter pylori

Franceschi¹,

2015

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The extragastric manifestations of Helicobacter pylori infection still remain a very strong topic throughout the H. pylori world. Indeed, H. pylori may interfere with many biological processes, both inside and outside of the stomach, possibly influencing or determining the occurrence of many diseases outside of the stomach. While its role in idiopathic thrombocytopenic purpura and sideropenic anemia has already been recognized, emerging evidence suggests that H. pylori may increase the risk of acute coronary syndrome, contribute to insulin resistance and be associated with neurodegenerative, respiratory, and other miscellaneous disorders previously associated with other conditions. Different pathogenic mechanisms have been hypothesized, including the induction of a low-grade inflammatory state and the occurrence of molecular mimicry mechanisms. This review summarizes the results of the most relevant studies published on this topic in the last year.There is a very strong interest of researchers from all over the world in the extragastric manifestations of Helicobacter pylori infection, as demonstrated by the high number of studies published in this field during the last year. Indeed, H. pylori is a very good model for studying host-bacterial interactions and very attractive for those interested in the role of gut microbiota in health and disease [1]. Here, we shall summarize the results of the most relevant studies published on this topic from

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“…H. pylori has also been linked to some extragastric diseases, including cardiovascular, neurological, hematologic, metabolic, and dermatologic disorders, such as nonalcoholic fatty liver disease (NAFLD), gallbladder cancer, colorectal polyps, dental caries, metabolic syndrome, idiopathic thrombocytopenic purpura (ITP), iron deficiency anemia (IDA), coronary artery disease (CAD), and Parkinson's disease (PD) [18]. …”

Section: Caga-positive H Pylori Strains-related Diseases (Figure 1)mentioning

confidence: 99%

The Role ofH. pyloriCagA in Regulating Hormones of Functional Dyspepsia Patients

Meng

Wang

Deng

et al. 2016

Gastroenterology Research and Practice

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Helicobacter pylori (H. pylori, Hp) colonizes the stomachs of approximately 20%–80% of humans throughout the world. The Word Healthy Organization (WHO) classified H. pylori as a group 1 carcinogenic factor in 1994. Recently, an increasing number of studies has shown an association between H. pylori infection and various extragastric diseases. Functional dyspepsia (FD) is considered a biopsychosocial disorder with multifactorial pathogenesis, and studies have shown that infection with CagA-positive H. pylori strains could explain some of the symptoms of functional dyspepsia. Moreover, CagA-positive H. pylori strains have been shown to affect the secretion of several hormones, including 5-HT, ghrelin, dopamine, and gastrin, and altered levels of these hormones might be the cause of the psychological disorders of functional dyspepsia patients. This review describes the mutual effects of H. pylori and hormones in functional dyspepsia and provides new insight into the pathogenesis of functional dyspepsia.

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Helicobacter pylori and Extragastric Diseases

Cited by 127 publications

References 77 publications

Helicobacter pylori Update: Gastric Cancer, Reliable Therapy, and Possible Benefits

Helicobacter pylori Update: Gastric Cancer, Reliable Therapy, and Possible Benefits

Extragastric Diseases and Helicobacter pylori

The Role ofH. pyloriCagA in Regulating Hormones of Functional Dyspepsia Patients

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