Association between Helicobacter pylori infection, eradication and diabetes mellitus

Abstract

Aims/Introduction It is suspected that Helicobacter pylori is associated with extradigestive diseases including diabetes. So far, a number of studies have examined the association between H. pylori and diabetes, and the results were conflicting. The aim of the present study was to examine the association between H. pylori infection, eradication and diabetes. Materials and Methods The present cross‐sectional study was carried out using data from annual health checkups carried out at the Toranomon Hospital Health Management Center. The status of H. pylori infection, determined by serum antibodies and history of eradication, was categorized into three groups as “never,” “current” and “past.” The association between H. pylori infection and diabetes was examined using logistic regression. Results Of 21,634 participants, 6,530 (30.2%) had a current or past history of H. pylori infection, and 1,184 (5.5%) were identified as having diabetes. Multivariate adjusted odds ratios for diabetes compared with the “never” group were 1.36 (95% confidence interval 1.10–1.67) for the “current” group and 0.92 (95% confidence interval 0.79–1.07) for the “past” group. The association between H. pylori infection and diabetes was also observed among participants without a history of eradication. Conclusions We found that current H. pylori infection was associated with an increased risk of diabetes, and the increased risk was not observed among participants after eradication. The results were concordant with the hypothesis that H. pylori infection increases the risk of diabetes. Further studies are necessary to validate the present results.

Review: Extragastric diseases andHelicobacter pylori

“…Multivariate regression analysis confirmed that H pylori infection was related to DM (OR, 1.25; 95% CI, 1.15-1.35), especially in participants aged ≥ 44 years. 12 Interestingly, in Japan, the risk of DM decreased from 1.36 (95% CI, 1.10-1.67) to 0.92 (95% CI, 0.79-1.07) after H pylori eradication, 13 concordant with the findings that H pylori eradication decreased HbA1c levels in diabetic patients. 14…”

The Association between Helicobacter pylori Infection and Glycated Hemoglobin A in Diabetes: A Meta-Analysis

“…It is estimated that about 4.4 billion people worldwide were infected with H. pylori in 2015 [42], and it is estimated that diabetes will reach 552 million by 2020 [43]. Kato et al have shown that H. pylori infection is associated with an increased risk of diabetes mellitus [44]. Refaeli et al showed that the prevalence of metabolic syndrome in H. pylori-infected patients was higher than that in uninfected patients [45].…”

The role of Helicobacter pylori in vitamin‐B12 deficiency due to metformin use

“…Several studies have suggested an association between H pylori , a common infection throughout the world, and glycemic control, insulin resistance, and T2D 17‐20 . On the other hand, some studies concluded that there was no such relationship 21 .…”

“…Another significant limitation of the study was that the H pylori infection was determined only with stool antigen test (without using UBT or histopathological tests) were also among the limitations of the study. This test has been reported to have false‐negative results when the antigens in stool are diluted, which might have influenced the results as they were not confirmed with another method of detection 18 …”