The enrichment of chlorogenic acid from Eucommia ulmoides leaves extract by mesoporous carbons

Qin, Guotong; Ma, Jing; Wei, Wei; Li, Jaja; Yue, Fangqing

doi:10.1016/j.jchromb.2018.04.036

Cited by 18 publications

(10 citation statements)

References 33 publications

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“…Therefore, CNPC1 could have a strong adsorption effect on active substances such as PMFs during the enrichment process. Similarly, an enrichment method for CGA using mesoporous carbon has been developed by Qin et al [ 28 ]. The mesopore volume of the carbon adsorbents was found to significantly influence the adsorption capacity.…”

Section: Resultsmentioning

confidence: 99%

“…GAs as adsorbents have shown their versatility as pollutant absorbers for the removal of dyes, formaldehyde, and other environmental toxins; on membranes for separating oil-in-water emulsion; and for efficient food toxin removal [ 22 , 23 ]. AC is often used as an adsorbent to remove dark-colored compounds [ 24 ], heavy metals [ 25 ], pesticides [ 26 ], and some organic acids [ 27 , 28 ], but few reports exist on the use of AC to enrich PMFs from CPW. In the adsorption process of AC, it is simpler and less time-consuming when compared to other methods.…”

Section: Introductionmentioning

confidence: 99%

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Nano Porous Carbon Derived from Citrus Pomace for the Separation and Purification of PMFs in Citrus Processing Wastes

Chen

Qiu

et al. 2020

Nanomaterials

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The by-product of citrus juice processing is a huge source of bioactive compounds, especially polymethoxyflavones (PMFs) and fibers. In this study, a method for the separation and purification of PMFs from citrus pomace was established based on citrus nanoporous carbon (CNPC) enrichment. Different biomass porous carbons were synthesized, their adsorption/desorption characteristics were evaluated, and the CNPCs from the peel of Citrus tangerina Tanaka were found to be best for the enrichment of PMFs from the crude extracts of citrus pomace. Using this method, six PMF compounds including low-abundant PMFs in citrus fruits such as 5,6,7,4′-tetramethoxyflavone and 5-hydroxy-6,7,8,3′,4′-pentamethoxyflavone can be simultaneously obtained, and the purities of these compounds were all higher than 95%, with the highest purity of nobiletin reaching 99.96%. Therefore, CNPCs have a great potential for the separation and purification of PMFs in citrus processing wastes, potentially improving the added value of citrus wastes. We also provide a method reference for disposing of citrus pomace in the future.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nano Porous Carbon Derived from Citrus Pomace for the Separation and Purification of PMFs in Citrus Processing Wastes

Chen

Qiu

et al. 2020

Nanomaterials

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“…It is synthesized by the condensation of caffeic acid and quinic acid 21 . CA is an important active component in many edible plants and medicinal plants, which is widely distributed in plants, from high dicotyledons to ferns, but there are few plants with high content 22 . CA is mainly in the plant family of Eucommia, Lonicerae and Artemisia, including eucommia, honeysuckle, artemisia, artemisia sunflowers, relay flowers, coffee and cocoa trees 23 .…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection in vitro and in vivo

Tan

Gao

et al. 2020

Sci Rep

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The study aimed to investigate the antibacterial effect and potential mechanisms of chlorogenic acid (CA) in Klebsiella pneumonia (KPN) induced infection in vitro and in vivo. 62 KPN strains were collected from the First People’s Hospital of Yunnan Province. CA and CA combined Levofloxacin (LFX) were detected for KPN biofilm (BF) formation in vitro. The lung infection mice model were established by KPN. The effect of CA (500 mg/kg), LFX (50 mg/kg) and CA combined LFX (250 mg/kg + 25 mg/kg) were evaluated through the survival of mice, the changes of inflammation factors of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β and IL-6 in serum, the histopathological analysis of lung and the protein expression of NLRP3 signaling pathway in vivo. A total of 62 KPNs were isolated and identified, of which 13 (21%) strains were BF positive. 8 (13%) strains were extended spectrum β-lactamase strains (ESBLs), and 20 (32%) strains are ESBLs biofilm positive. In vitro study, CA and LFX showed a synergistic effect on KPN biofilm formation. In vivo mice experiment, CA, especially CA + LFX treated group significantly decreased the serum levels of TNF-α, IL-1β and IL-6, improved the survival ratio and lung pathology changes, and also reduced the protein expression of ASC, caspase 1 p20, IL-1β and phosphor NF-κB p65. CA could effectively alleviate lung infection of KPN infected mice, and the antibacterial effection is strengthened by combined with LFX. The study provide a theroy basis for making rational and scientific antibacterial therapy strategy in clinic.

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“…Owing to its unique and tunable pore structures, high surface areas and mechanical stability, mesoporous carbons (pore size between 2 and 50 nm) have been proven to be a kind of efficient adsorbents for adsorptive natural products. The study shown that mesoporous carbons were more suitable for adsorbing macromolecules, such as mesoporous carbons have been used by Qin et al to enrichment of chlorogenic acid from eucommia ulmoides leaves (Qin et al, 2018). Li et al synthesized two mesoporous carbons via a hydrothermal treatment approach, and evaluated adsorption performance of two mesoporous carbons for berberine hydrochloride and matrine from water (Li et al, 2018b).…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Adsorption of Phenylethanoid Glycosides on Mesoporous Carbon

Pei

Zhang

2019

Front. Chem.

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PhGs are the major active compounds of Cistanche tubulosa, and it is extremely desirable for obtaining high purification of PhGs by adsorption from their extracts. To explore highly efficient adsorption of PhGs, a novel adsorption material for the efficient separation and purification of phenylethanoid glycosides (PhGs) from Cistanche tubulosa was explored. The three mesoporous carbons of ordered mesoporous carbon (CMK-3), disordered mesoporous carbon (DMC), and three-dimensional cubic mesoporous carbon (CMK-8) were compared for adsorption of PhGs. Meanwhile, adsorption isotherms, adsorption kinetics, and the optimization of adsorption conditions were investigated. The results indicated that CMK-3 showed the highest adsorption capacity of 358.09 ± 4.13 mg/g due to its high specific surface area, large pore volume and oxygen-containing functional groups. The experimental data can be accurately described using the Langmuir model and pseudo-second-order model. The intra-particle diffusion model suggested that the rate-limiting steps of adsorption were intra-particle diffusion.

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The enrichment of chlorogenic acid from Eucommia ulmoides leaves extract by mesoporous carbons

Cited by 18 publications

References 33 publications

Nano Porous Carbon Derived from Citrus Pomace for the Separation and Purification of PMFs in Citrus Processing Wastes

Nano Porous Carbon Derived from Citrus Pomace for the Separation and Purification of PMFs in Citrus Processing Wastes

Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection in vitro and in vivo

Highly Efficient Adsorption of Phenylethanoid Glycosides on Mesoporous Carbon

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