1997
DOI: 10.1111/j.1651-2227.1997.tb08821.x
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The enigma of pyloric stenosis. Some thoughts on the aetiology

Abstract: A theory is advanced about the cause of pyloric stenosis of infancy (PS). Developmental changes will conspire to produce pathogenetic gastric hyperacidity within the first 4 weeks of life in babies who develop PS. The prime cause will be an increased gastric acidity due to a genetically determined supernormal parietal cell mass. This theory satisfactorily explains many known clinical features.

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Cited by 21 publications
(10 citation statements)
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“…Foveolar hyperplasia after administration of prostaglandins has been implicated in the development of this condition (32). The hypergastrinemia hypothesis proposes that an inherited increase in the number of parietal cells initiates a cycle of increased acid production, repeated pyloric contraction, and delayed gastric emptying (33). Development of IHPS after initiation of feedings, increased postprandial gastrin levels, markedly increased gastric acid secretion in infants with IHPS, and the induction of IHPS in puppies by means of pentagastrin infusion (34) support this hypothesis.…”
Section: Etiologic Considerationsmentioning
confidence: 99%
“…Foveolar hyperplasia after administration of prostaglandins has been implicated in the development of this condition (32). The hypergastrinemia hypothesis proposes that an inherited increase in the number of parietal cells initiates a cycle of increased acid production, repeated pyloric contraction, and delayed gastric emptying (33). Development of IHPS after initiation of feedings, increased postprandial gastrin levels, markedly increased gastric acid secretion in infants with IHPS, and the induction of IHPS in puppies by means of pentagastrin infusion (34) support this hypothesis.…”
Section: Etiologic Considerationsmentioning
confidence: 99%
“…CD34ϩ dendritic fibroblasts have previoulsy been described in various tissues (Lindenmayer and Miettinen, 1995;Nickoloff, 1991;Weiss and Nickoloff, 1993;Yamazaki and Eyden, 1995, 1997.…”
Section: Icc and Cancermentioning
confidence: 99%
“…IHPS has been known for more than a century (Hayes and Goldenberg, 1957) but it remains a puzzling disorder (Rogers, 1997). The genetic susceptibility to develop IHPS seems to be multifactorial (Mitchell and Risch, 1993).…”
Section: Infantile Hypertrophic Pyloric Stenosis (Ihps)mentioning
confidence: 99%
“…Manoma, kad įtakos turi įvairūs genetiniai ir aplinkos veiksniai. Įrodyta, kad ligos atsiradimą lemia naujagimių hipergastrinemija ir skrandžio rūgštingumo padidėjimas [6]. Rizikos veiksniais laikomi neišnešiotumas (mažiau 37 gestacijos savaičių) [7], motinos rūkymas nėštumo metu [7,8], naujagimių maitinimas iš buteliuko [9][10][11] ir makrolidų (eritromicino) vartojimas [12,13].…”
Section: įVadasunclassified