The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity

Nguyen-Thi, Ngoc-Tram; Tran, Linh Phuong Pham; Cao, Minh-Tri; Tran, The-Nam; Nguyen, Ngoc Thi Bich; Nguyen, Cong Hao; Nguyen, Dai-Hai; Than, Van Thai; Le, Quang Tri; Trung, Nguyen Quang

doi:10.3390/pr7110805

Cited by 11 publications

(7 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hollow mesoporous silica nanoparticles were synthesized through a hard‐template method via three main steps, which was reported in detailed in the previous publication 23,24 . In the first step, dSiO 2 as hard templates were prepared by a modified Stober method from TEOS, NH 3 and EtOH 25 .…”

Section: Methodsmentioning

confidence: 99%

Simply and effectively control the shell thickness of hollow mesoporous silica nanoparticles by polyethylene glycol for drug delivery applications

Nguyen

Tran

Truong‐Thi

et al. 2022

J of Applied Polymer Sci

View full text Add to dashboard Cite

This study reports for the first time the usage of polyethylene glycol (PEG) as the capping agent to control mesoporous shell thickness of hollow mesoporous silica nanoparticles (HMSN)—a promising nanocarrier. HMSN was synthesized with hard template method and PEG with different molecular weights and concentrations would be added at the mesoporous coating. The samples dSiO2@MSN synthesized with and without PEG were analyzed DLS, field‐emission scanning electron microscopy, Brunauer–Emmett–Teller and Barrett–Joyner–Halenda to characterize their mesoporous shells. Meanwhile transmission electron microscope, Zeta potential, energy dispersive X‐ray spectroscopy, Fourier‐transform infrared, loading capacity, release profile and cytotoxicity analysis was conducted to characterize HSMNs. As PEG's molecular weight or concentration increased, the mesoporous shell thickness gradually raised. Particles synthesized in the presence of 2% PEG 6000 retained the monodispersed spherical morphology with a particle diameter of 95.40 nm and a mesoporous shell thickness of 14.40 nm, which was about 7.0 nm thicker. dSiO2@MSN‐P owned equal mesopore diameter and higher surface area compared to dSiO2@MSN‐0. HMSN‐P showed similar loading capacity but better sustained release profile than HMSN‐0. Moreover, both HMSN‐0 and HMSN‐P performed as biocompatible materials. This study would contribute a simple and effective method to control the shell thickness of HMSN with PEG for drug delivery applications.

show abstract

Section: Methodsmentioning

confidence: 99%

Simply and effectively control the shell thickness of hollow mesoporous silica nanoparticles by polyethylene glycol for drug delivery applications

Nguyen

Tran

Truong‐Thi

et al. 2022

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…The loading efficiency (LE%) and loading capacity (LC%) of lavender oil in the niosomes were determined using a method described previously [32,33]. The final suspension was centrifuged (12,000× g, 15 min, 4 • C).…”

Section: Loading Efficiency and Loading Capacity Of Lavender Oilmentioning

confidence: 99%

Safety of Lavender Oil-Loaded Niosomes for In Vitro Culture and Biomedical Applications

et al. 2022

View full text Add to dashboard Cite

(1) Background: Essential oils have long been used as therapeutic agents. Lavender (Lavandula angustifolia) oil (LO) is an antispasmodic, anticonvulsant, relaxant, painkilling, and antimicrobial essential oil investigated as a natural substance for biomedical therapies. Nanoparticles have shown significant promise in improving drug delivery and efficacy. Considering these benefits, the aim of this study was to evaluate the toxicity of LO and lavender oil niosomes (LONs) in stem cells and myofibroblast models cultured in vitro. (2) Methods: Adipose tissue-derived stem cells and myometrial cells were cultured with LO or LONs at different concentrations (0, 0.016%, 0.031%, and 0.063%) and toxicity was evaluated with PrestoBlue™ and live/dead assay using calcein and ethidium homodimer. (3) Results: Cell viability was similar to controls in all groups, except in 0.063% LO for myometrial cells, which showed lower viability than the control medium. (4) Conclusion: These results suggest that both LO and LONs are safe for cell culture and may be used for pharmaceutical and biomedical therapies in future applications in regenerative medicine.

show abstract

“…In assaying the effectiveness of nanoparticles in general, and of liposome in particular, size is one critical parameter among others. Normally, the nanoscale of a delivery structure will help it to avoid being taken up by the bodily mechanism and then be eliminated, and hence enable the carrier structure to establish its effectiveness in delivering drugs [28][29][30][31]. The same purpose is placed on the measuring of zeta potential: with the surface-modified liposomes, their ability to increase the circulation time in the bloodstream relies on the coating moieties [32,33].…”

Section: Particle Size and Zeta Potentialmentioning

confidence: 99%

Development, Characterization and In Vitro Evaluation of Paclitaxel and Anastrozole Co-Loaded Liposome

Vu¹,

Nguyen

et al. 2020

Processes

Self Cite

View full text Add to dashboard Cite

Paclitaxel (PTX) and anastrozole (ANA) have been frequently applied in breast cancer treatment. PTX is well-known for its anti-proliferative effect meanwhile ANA has just been discovered to act as an estrogen receptor α (ERα) ligand. The combination therapy of PTX and ANA is expected to improve treating efficiency, as ANA would act as a ligand binding with the ERα gene expressed in breast cancer cells and thereafter PTX would inhibit the division and cause death to those cancer cells. In this study, liposome-based nanocarriers (LP) were developed for co-encapsulation of PTX and ANA to improve the efficacy of the combined drugs in an Estrogen receptor-responsive breast cancer study. PTX-ANA co-loaded LP was prepared using thin lipid film hydration method and was characterized for morphology, size, zeta potential, drug encapsulation and in vitro drug release. In addition, cell proliferation (WST assay) and IN Cell Analyzer were used for in vitro cytotoxicity studies on a human breast cancer cell line (MCF-7). Results showed that the prepared LP and PTX-ANA-LP had spherical vesicles, with a mean particle size of 170.1 ± 13.5 nm and 189.0 ± 22.1 nm, respectively. Controlled and sustained releases were achieved at 72 h for both of the loaded drugs. The in vitro cytotoxicity study found that the combined drugs showed higher toxicity than each single drug separately. These results suggested a new approach to breast cancer treatment, consisting of the combination therapy of PTX and ANA in liposomes based on ER response.

show abstract

The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity

Cited by 11 publications

References 35 publications

Simply and effectively control the shell thickness of hollow mesoporous silica nanoparticles by polyethylene glycol for drug delivery applications

Simply and effectively control the shell thickness of hollow mesoporous silica nanoparticles by polyethylene glycol for drug delivery applications

Safety of Lavender Oil-Loaded Niosomes for In Vitro Culture and Biomedical Applications

Development, Characterization and In Vitro Evaluation of Paclitaxel and Anastrozole Co-Loaded Liposome

Contact Info

Product

Resources

About