Safety of Lavender Oil-Loaded Niosomes for In Vitro Culture and Biomedical Applications

Vilela, Janice M.V.; Moghassemi, Saeid; Dadashzadeh, Arezoo; Dolmans, Marie-Madeleine; Azevedo, Ricardo Bentes; Amorim, Christiani Andrade

doi:10.3390/nano12121999

Cited by 11 publications

(4 citation statements)

References 44 publications

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“…Vilela et al [ 75 ] studied the in vitro safety of lavender oil-loaded niosomes on adipose tissue-derived stem cells (ASCs) and myometrial cells. The cell viability test indicated no significant difference between the viability of untreated cells and those treated with niosomes indicating the biocompatibility of the carrier.…”

Section: Biocompatibility Of Nanovesicles For Dermal and Transdermal ...mentioning

confidence: 99%

The Evolution of Emerging Nanovesicle Technologies for Enhanced Delivery of Molecules into and across the Skin

Touitou,

Natsheh

2024

Pharmaceutics

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This review focuses on nanovesicular carriers for enhanced delivery of molecules into and across the skin, from their design to recent emerging technologies. During the last four decades, several approaches have been used aiming to design new nanovesicles, some of them by altering the properties of the classic phospholipid vesicle, the liposome. Phospholipid nanovesicular systems, including the phospholipid soft vesicles as well as the non-phospholipid vesicular carries, are reviewed. The altered nanovesicles have served in the manufacture of various cosmetic products and have been investigated and used for the treatment of a wide variety of skin conditions. The evolution and recent advances of these nanovesicular technologies are highlighted in this review.

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Section: Biocompatibility Of Nanovesicles For Dermal and Transdermal ...mentioning

confidence: 99%

The Evolution of Emerging Nanovesicle Technologies for Enhanced Delivery of Molecules into and across the Skin

Touitou,

Natsheh

2024

Pharmaceutics

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“…Niosomes have been used as delivery systems for a wide range of natural extracts, including flavonoids [ 137 ], terpenoids [ 138 ], alkaloids [ 139 ], and polyphenols [ 140 ], demonstrating that niosomes can improve the solubility, stability, and bioavailability of these natural extracts, thereby enhancing their therapeutic efficacy.…”

Section: Lipid-based Nano-systemsmentioning

confidence: 99%

Biopolymer- and Lipid-Based Carriers for the Delivery of Plant-Based Ingredients

2023

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Natural ingredients are gaining increasing attention from manufacturers following consumers’ concerns about the excessive use of synthetic ingredients. However, the use of natural extracts or molecules to achieve desirable qualities throughout the shelf life of foodstuff and, upon consumption, in the relevant biological environment is severely limited by their poor performance, especially with respect to solubility, stability against environmental conditions during product manufacturing, storage, and bioavailability upon consumption. Nanoencapsulation can be seen as an attractive approach with which to overcome these challenges. Among the different nanoencapsulation systems, lipids and biopolymer-based nanocarriers have emerged as the most effective ones because of their intrinsic low toxicity following their formulation with biocompatible and biodegradable materials. The present review aims to provide a survey of the recent advances in nanoscale carriers, formulated with biopolymers or lipids, for the encapsulation of natural compounds and plant extracts.

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“…The observation of morphology changes associated with apoptosis after treatment with AuNPs in HT-29 cells suggested the potential use of AuNPs as a pro-apoptotic drug in the treatment of colon cancer [45]. Vilela et al [46] reported that there was no statistically significant difference seen in the vitality of adipose tissue-derived stem cells (ASCs) and myometrial cells after treatment with lavender oil (LO). Moreover, the application of lavender oil and its derivative, niosomal lavender oil (LON), demonstrated cell viability comparable to that of the control culture, indicating their safety for use in cell culture.…”

Section: Antibacterial and Antibiofilm Activity Of The Synthesized Na...mentioning

confidence: 99%

Nanoemulsion of Lavandula angustifolia Essential Oil/Gold Nanoparticles: Antibacterial Effect against Multidrug-Resistant Wound-Causing Bacteria

Fadel,

Elwakil,

Fawzy

et al. 2023

Molecules

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Hospitalized patients are severely impacted by delayed wound healing. Recently, there has been a growing focus on enhancing wound healing using suitable dressings. Lavandula angustifolia essential oil (LEO) showed potential antibacterial, anti-inflammatory, and wound healing properties. However, the prepared gold nanoparticles possessed multifunctional properties. Consequently, the present investigation aimed to synthesize a novel nanosystem consisting of nano-Lavandula angustifolia essential oil and gold nanoparticles prepared through ultrasonic nanoemulsifying techniques in order to promote wound healing and combat bacterial infection. LEO showed potent antibacterial activity against Klebsiella pneumoniae, MRSA and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 32, 16 and 16 µg/mL, respectively, while exhibiting low activity against Proteus mirabilis. Interestingly, the newly formulated nano-gold/nano-Lavandula angustifolia penetrated the preformed P. mirabilis biofilm with a full eradication of the microbial cells, with MIC and MBEC (minimal biofilm eradication concentration) values reaching 8 and 16 µg/mL, respectively. The cytotoxic effect of the novel nanoformula was also assessed against WI-38 fibroblasts vero (normal) cells (IC50 = 0.089 mg/mL) while nano-gold and nano-Lavandula angustifolia showed higher results (IC50 = 0.529, and 0.209 mg/mL, respectively). Nano-gold/nano-Lavandula angustifolia formula possessed a powerful wound healing efficacy with a 96.78% wound closure. These findings revealed that nano-gold/nano-Lavandula angustifolia nanoemulsion can inhibit bacterial growth and accelerate the wound healing rate.

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Safety of Lavender Oil-Loaded Niosomes for In Vitro Culture and Biomedical Applications

Cited by 11 publications

References 44 publications

The Evolution of Emerging Nanovesicle Technologies for Enhanced Delivery of Molecules into and across the Skin

The Evolution of Emerging Nanovesicle Technologies for Enhanced Delivery of Molecules into and across the Skin

Biopolymer- and Lipid-Based Carriers for the Delivery of Plant-Based Ingredients

Nanoemulsion of Lavandula angustifolia Essential Oil/Gold Nanoparticles: Antibacterial Effect against Multidrug-Resistant Wound-Causing Bacteria

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