The Endocrine Regulation of Chicken Growth

Kim, Jin Wook

doi:10.5713/ajas.2010.10329

Cited by 41 publications

(23 citation statements)

References 103 publications

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“…Growth hormone (GH) is necessary for differentiation of muscle, adipocytes, and other cells to modulate development and growth (Kim 2010). In the present study, increased expression of hepatic cGH gene was observed in AA injected embryos during pre-hatch period, indicating an effective way to increase the size of the chick without decreasing hatchability (Ohta et al 1999).…”

Section: Discussionmentioning

confidence: 56%

Differential expression of growth and immunity related genes influenced by in ovo supplementation of amino acids in broiler chickens

Bhanja¹,

Sudhagar²,

Goel³

et al. 2014

CZECH J ANIM SCI

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The present study was aimed at investigating the role of in ovo administered amino acids: lysine, arginine, threonine or methionine plus cysteine (Met+Cys) in 14-day embryos on expression profile of growth (chicken growth hormone (cGH), insulin like growth factors (IGF) I and II, and mucin) and immunity related genes (IL-2, IL-4, . On incubation day (ID) 18, higher (P < 0.01) cGH and mucin gene expression was observed in lysine, threonine, arginine or Met+Cys injected embryos, while IGF-II expression was higher in threonine, arginine or Met+Cys injected embryos on ID 20. Expression of growth genes was down regulated (P < 0.01) on day of hatch in most of the amino acids injected chicks. On day 7 post-hatch (PH), threonine or arginine exhibited higher expression of cGH, IGF-I, and IGF-II but higher mucin gene expression only on day 14 PH. Threonine or Met+Cys injected birds had higher expression of IL-6 and TNF-α, while arginine injected birds had higher TNF-α expression. Lysine, threonine or Met+Cys injected birds had higher IL-2, but lower of IL-12 and IFN-γ gene expression. It is concluded that arginine and threonine enhanced the expression of growth related genes, while threonine and Met+Cys modulated expression of immune genes in broiler chickens.

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Section: Discussionmentioning

confidence: 56%

Differential expression of growth and immunity related genes influenced by in ovo supplementation of amino acids in broiler chickens

Bhanja¹,

Sudhagar²,

Goel³

et al. 2014

CZECH J ANIM SCI

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“…An inverse pattern revealed greater IGF-I mRNA transcription in the liver of broilers fed high methionine concentration. The GHR expression may be reduced directly by the amount of GH in this organism, but also by the influence of GH that can occur via IGF-I (Kim et al, 2010). Therefore, diets with higher methionine concentrations increased IGF-I concentrations and decreased GHR gene expression.…”

Section: Discussionmentioning

confidence: 99%

Dietary methionine effects on IGF-I and GHR mRNA expression in broilers

Gasparino

Ar³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. This study aimed to evaluate liver and breast muscle insulin-like growth factor I (IGF-I) and growth hormone receptor (GHR) gene expression between broilers fed different methionine levels and sources. Broiler chicks were 22 to 42 days old, distributed in 5 treatments (control diet, DL1 -0.08% DL-methionine, DL2 -0.24% DL-methionine, MHA-FA1 -0.11% methionine hydroxy analoguefree acid, and MHA-FA2 -0.33% methionine hydroxy analogue-free acid). The broilers were euthanized by cervical dislocation. RNA was extracted from liver and breast muscle, followed by cDNA synthesis and amplification using qRT-PCR. DL2 methionine supplementation provided best animal performance results. GHR and IGF-I gene expression in the muscle tissue was not affected by methionine supplementation. IGF-I gene expression in the liver was higher in animals fed methionine supplementation than in animals fed control diet. IGF-I mRNA levels in broilers fed DL2 were greater than DL1 (1.56 vs 0.97 AU) and greater than MAH-FA1 and MAH-FA2. Broilers 6415 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (4): 6414-6423 (2013) Gene expression in broilers fed DL2 increased significantly GHR gene expression in the liver than animals fed the control diet. Addition of methionine improved animal performance by stimulating synthesis and release of growth factor.

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“…bold shows EcoRV restriction sites; box shows g.2248G>A GH SNP target (GenBank accession number: AY461843.1) . Kim et al (2010) explain that the GH-GHR complexes activate hepatic IGF-I secretion, which stimulates the differentiation and proliferation of bone and muscle cell. Our study in the GH|EcoRV genotyping generated the GG genotype predominantly (0.749), the AG genotype as a second majority (0.247), and almost no AA genotype was found (0.005) in overall population.…”

Section: Discussionmentioning

confidence: 99%

“…The chicken growth hormone is widely known as a major hormone that acts directly on chicken development and metabolism (Kim, 2010) and relates to egg production (Su et al, 2014;Vu & Ngu, 2016). GH regulates a variety of physiological functions such as growth, body composition, egg production, aging, reproduction, sexual maturation, and functionality of the central nervous system (Gosney et al, 2012;Hrabia et al, 2008;Hull & Harvey, 2014;Stephen et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

The Associations of GH and GHR Genes with Carcass Components in Indonesian Kampung and Broiler Chicken Cross

Khaerunnisa

Jakaria

Arief

et al. 2017

Med Pet

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The chicken growth hormone (GH) and its receptor (growth hormone receptor, GHR) play important roles in chicken performances due to their crucial functions in growth. The variations of GH and GHR genes were then thought to be associated with the variations of the performances. This experiment was designed to identify the g.2248G>A GH and the g.565G>A GHR loci polymorphisms and to evaluate their associations with carcass components in Kampung and broiler chicken cross. A total of 215 chickens including 4 chicken populations (Kampung, Cobb broiler, F1, and F2 Kampung x broiler chicken cross) were screened to identify polymorphism using PCR-RFLP technique with EcoRV and Eco72I restriction enzyme for GH and GHR loci, respectively. The carcass components were recorded at 26 weeks of age on F2 Kampung and broiler chicken cross (42 chickens) for association study. Both the g.2248G>A GH and the g.565G>A GHR loci were polymorphic with two alleles (G and A) and three genotypes (GG, AG, and AA). The GG genotype and the G allele of GH locus were predominant in all chicken populations. While in GHR locus, the AA genotype and the A allele were found to be higher in all chicken populations. The association study showed that the g.565G>A GHR locus polymorphism had significant effect on carcass components, including live weight, carcass weight, breast weight, thighs weight, breast muscle weight, and thighs muscle weight. There was no significant association was found between the g.2248G>A GH genotype and carcass components. It could be concluded that the g.2248G>A GH and the g.565G>A GHR loci were polymorphic in Kampung and broiler chicken cross and the g.565G>A GHR locus was accosiated with carcass components. This g.565G>A GHR SNP might be an important candidate marker for chicken growth and muscle mass improvement. Keywords: Kampung chicken cross, growth hormone, growth hormone receptor, gene polymorphisms, carcass ABSTRAKHormon pertumbuhan dan reseptor hormon pertumbuhan memiliki peran penting dalam performa pertumbuhan ayam. Tujuan penelitian ini adalah mengidentifikasi keragaman gen hormon pertumbuhan (lokus g.2248G>A GH) dan gen reseptor hormon pertumbuhan (lokus g.565G>A GHR) dan mengevaluasi pengaruhnya pada komponen karkas pada ayam silangan Kampung dan broiler. Penentuan genotipe dilakukan pada 215 ekor ayam, yang terdiri atas 4 populasi (Kampung, ras pedaging strain Cobb, silangan F1 dan F2 Kampung x ras pedaging strain Cobb) menggunakan enzim pemotong EcoRV dan Eco72I masing-masing untuk fragmen lokus g.2248G>A GH dan lokus g.565G>A GHR. Analisis asosiasi dengan komponen karkas dilakukan pada populasi ayam silangan F2 Kampung x ras pedaging strain Cobb umur 26 minggu. Kedua lokus tersebut bersifat polimorfik dengan dua alel yang ditemukan (alel A dan G) dan tiga genotipe (genotipe GG, AG, dan AA). Genotipe GG dan alel G pada lokus g.2248G>A GH ditemukan dalam frekuensi tertinggi di semua populasi yang diuji. Sementara pada lokus g.565G>A GHR, genotipe AA dan alel A ditemukan paling dominan. Analisis asosiasi...

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The Endocrine Regulation of Chicken Growth

Cited by 41 publications

References 103 publications

Differential expression of growth and immunity related genes influenced by in ovo supplementation of amino acids in broiler chickens

Differential expression of growth and immunity related genes influenced by in ovo supplementation of amino acids in broiler chickens

Dietary methionine effects on IGF-I and GHR mRNA expression in broilers

The Associations of GH and GHR Genes with Carcass Components in Indonesian Kampung and Broiler Chicken Cross

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