The Empty Sella syndrome secondary to Rathke's cleft cyst

Baldini, Mario; Mosca, L.; Princi, L

doi:10.1007/bf02074522

Cited by 12 publications

(2 citation statements)

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“…Muciparous features have also been well-described in human hypophysis microcysts observed in light micro scopy by Shanklin [3. 4], as well as in giant cysts from Rathke's pouch sometimes responsible for a hypo pituitarism syndrome [5][6][7][8], The presence of endocrine cells in the epithelium of Rathke's pouch microcysts is worthy of further study as it seems to suggest that en docrine cells can differentiate from cystic epithelium even in the adult.…”

Section: Discussionmentioning

confidence: 99%

“…2J. In man, muciparous microcysts in 13% of the adenohypophyses studied by light microscopy were found by Shanklin [3][4]. Rarely these microcysts can grow to a considerable size and give the clinical signs of hypopituitarism [5][6][7][8]. By most authors these microcysts are considered deriving from embryonal remnants of Rathke's pouch, thus being the equivalent of that hy pophyseal cleft set between the pars distalis and the pars intermedia which is seen in some species.…”

Section: Introductionmentioning

confidence: 99%

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An Ultrastructural Study on Muciparous Microcysts of the Human Adenohypophysis

Cinti

Sbarbati

Balercia

et al. 1985

Cells Tissues Organs

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The microcysts found in two adenohypophyses removed from patients with nonsecreting adenomas of this gland have been studied. In one case the cysts were completely surrounded by neoplastic tissue, whereas in the second they were located within the normal parenchyma. The cysts were surrounded by a basement membrane, and appeared to contain a finely granular weakly electron-dense substance. Their walls were lined by mostly cubic cells with microvilli, joined by junctional complexes. Intracytoplasmic microlumina could be seen in some of these cells. Cells showing cilia with a 9 + 2 fibrillar pattern and cells with mucosecretory differentiation were also present. Furthermore endocrine cells were also found in the cyst-lining epithelium. The ultrastructural aspects of the cyst cells lead to reject the hypothesis that these are derived from folliculostellate cells. Besides, intermediate aspects between cyst cells and tumor cells were never visible. Therefore it seems likely that a relationship between adenoma and cyst cells does not exist and that cyst cells originate from remnants of Rathke’s pouch with a ciliate or mucosecretory differentiation. The presence of endocrine cells in the cyst-lining epithelium deserves further study, for it seems to indicate that an endocrine differentiation may occur in the adult, too. To our knowledge this is the first ultrastructural study of these structures in adult human pituitary gland.

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Section: Discussionmentioning

confidence: 99%