The Emerging Role of MicroRNAs and Other Non-Coding RNAs in Cancer Cachexia

Santos, Julia M.; Silva, Sara Peixoto da; Costa, Rui M. Gil da; Medeiros, Rui

doi:10.3390/cancers12041004

Cited by 32 publications

(26 citation statements)

References 58 publications

(164 reference statements)

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“…In VMC, miRNAs are differentially expressed not only in cells but also in blood. The stability of miRNAs in the blood can be maintained by binding RNA binding proteins and enveloping them within extracellular vesicles (Santos et al, 2020 ). There has been other disease using miRNAs as candidate diagnostic tool (Chen et al, 2019 ), but VMC has not yet been.…”

Section: The Role Of Mirnas In Cvb3-induced Vmcmentioning

confidence: 99%

“…Future therapies may focus on helping the host clear viruses or decreasing the viral replication by changing the expression of these important ncRNAs. In addition, considering that some ncRNAs of blood will change significantly in the state of disease and have good stability in peripheral circulation, so they have great potential in the field of VMC diagnosis (Regouc et al, 2020 ; Santos et al, 2020 ). In this review, we will mainly describe the potential roles of miRNAs, lncRNAs, and circRNAs in the pathogenesis, diagnosis, and treatment of CVB3-induced viral myocarditis.…”

Section: Introductionmentioning

confidence: 99%

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The Role of Non-coding RNAs in Viral Myocarditis

Zhang

Xiong

Zeng

et al. 2020

Front. Cell. Infect. Microbiol.

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Viral myocarditis (VMC) is a disease characterized as myocardial parenchyma or interstitium inflammation caused by virus infection, especially Coxsackievirus B3 (CVB3) infection, which has no accurate non-invasive examination for diagnosis and specific drugs for treatment. The mechanism of CVB3-induced VMC may be related to direct myocardial damage of virus infection and extensive damage of abnormal immune response after infection. Non-coding RNA (ncRNA) refers to RNA that is not translated into protein and plays a vital role in many biological processes. There is expanding evidence to reveal that ncRNAs regulate the occurrence and development of VMC, which may provide new treatment or diagnosis targets. In this review, we mainly demonstrate an overview of the potential role of ncRNAs in the pathogenesis, diagnosis and treatment of CVB3-induced VMC.

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Section: The Role Of Mirnas In Cvb3-induced Vmcmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of Non-coding RNAs in Viral Myocarditis

Zhang

Xiong

Zeng

et al. 2020

Front. Cell. Infect. Microbiol.

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“…Regulatory RNAs. microRNAs (miRNAs) and non-coding RNAs (ncRNAs) have been reported to be involved in cachexia at the sites of skeletal muscle [ 195 , 196 , 197 , 198 ].…”

Section: Mitochondria and Cancer Cachexiamentioning

confidence: 99%

Mitochondria at Work: New Insights into Regulation and Dysregulation of Cellular Energy Supply and Metabolism

Schirrmacher¹

2020

Biomedicines

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Mitochondria are of great relevance to health, and their dysregulation is associated with major chronic diseases. Research on mitochondria—156 brand new publications from 2019 and 2020—have contributed to this review. Mitochondria have been fundamental for the evolution of complex organisms. As important and semi-autonomous organelles in cells, they can adapt their function to the needs of the respective organ. They can program their function to energy supply (e.g., to keep heart muscle cells going, life-long) or to metabolism (e.g., to support hepatocytes and liver function). The capacity of mitochondria to re-program between different options is important for all cell types that are capable of changing between a resting state and cell proliferation, such as stem cells and immune cells. Major chronic diseases are characterized by mitochondrial dysregulation. This will be exemplified by cardiovascular diseases, metabolic syndrome, neurodegenerative diseases, immune system disorders, and cancer. New strategies for intervention in chronic diseases will be presented. The tumor microenvironment can be considered a battlefield between cancer and immune defense, competing for energy supply and metabolism. Cancer cachexia is considered as a final stage of cancer progression. Nevertheless, the review will present an example of complete remission of cachexia via immune cell transfer. These findings should encourage studies along the lines of mitochondria, energy supply, and metabolism.

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“… 10 It has been proved that many lncRNAs took part in the tumor process and are expected to become tumor markers. 11 The role of lncRNA in DLBCL has also been reported. Peng et al found that lncRNA LUNAR1 increased in DLBCL cell lines and tissues.…”

Section: Introductionmentioning

confidence: 97%

LncRNA SBF2-AS1 Promotes Diffuse Large B-Cell Lymphoma Growth by Regulating FGFR2 via Sponging miR-494-3p

Fu¹,

Liu²

2021

CMAR

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Purpose: Currently, there is no efficient and feasible method for diffuse large B-cell lymphoma (DLBCL) in clinical practice, and the main reason is the unclear pathogenesis of DLBCL, which leads to a high fatality rate of DLBCL. Methods: Therefore, it is meaningful to explore the molecular mechanism of DLBCL and find a targeted therapeutic approach from the molecular level. Results: Long non-coding RNA (lncRNA) SBF2-AS1 was highly expressed in DLBCL tissues and cell lines. Silencing of SBF2-AS1 inhibited the viability and growth of OCI-LY-3 cells. Furthermore, SBF2-AS1 acted as a sponge of miR-494-3p and inhibited its expression. And miR-494-3p directly targeted FGFR2. Functionally, forced expression of miR-494-3p or knockdown of FGFR2 removed the promoted effects of lncRNA SBF2-AS1 on DLBCL development. In vivo tumorigenesis experiments indicated SBF2-AS1 accelerated tumor growth via miR-494-3p/FGFR2 axis. Conclusion:Our study revealed that SBF2-AS1 promoted the growth of DLBCL, which were mediated by miR-494-3p/FGFR2 axis.

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The Emerging Role of MicroRNAs and Other Non-Coding RNAs in Cancer Cachexia

Cited by 32 publications

References 58 publications

The Role of Non-coding RNAs in Viral Myocarditis

The Role of Non-coding RNAs in Viral Myocarditis

Mitochondria at Work: New Insights into Regulation and Dysregulation of Cellular Energy Supply and Metabolism

LncRNA SBF2-AS1 Promotes Diffuse Large B-Cell Lymphoma Growth by Regulating FGFR2 via Sponging miR-494-3p

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