LncRNA SBF2-AS1 Promotes Diffuse Large B-Cell Lymphoma Growth by Regulating FGFR2 via Sponging miR-494-3p

Fu, Dongwei; Liu, Ai-Chun

doi:10.2147/cmar.s284258

Cited by 12 publications

(7 citation statements)

References 28 publications

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“…In contrast, miR-494 is known to be sponged by several lncRNAs. Suppression of miR-494 by the lncRNA PCAT29 promotes PTEN expression [27], while a similar action by the lncRNA SBF2-AS1 promotes FGFR2 expression [28]. The downregulation of NQO1 by miR-494 has been shown to inhibit the Nrf2 signaling pathway [20], and we previously reported that miR-494 induces a quiescent state in cancer cells by suppressing oxidative phosphorylation [29].…”

Section: Discussionmentioning

confidence: 98%

An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma

Nakashima

Fujiwara‐Tani

Mori

et al. 2022

IJMS

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Long non-coding RNAs (lncRNAs) play critical roles in human cancers. HOXA11 anti-sense RNA (HOXA11-AS) is an lncRNA belonging to the homeobox (HOX) gene cluster that promotes liver metastasis in human colon cancer. However, its role and mechanism of action in human oral squamous cell carcinoma (OSCC) are unclear. In this study, we investigated HOXA11-AS expression and function in human OSCC tissues and cell lines, as well as a mouse model of OSCC. Our analyses showed that HOXA11-AS expression in human OSCC cases correlates with lymph node metastasis, nicotinamide adenine dinucleotide (NAD)(P)H: quinone oxidoreductase 1 (NQO1) upregulation, and dihydronicotinamide riboside (NRH): quinone oxidoreductase 2 (NQO2) downregulation. Using the human OSCC cell lines HSC3 and HSC4, we demonstrate that HOXA11-AS promotes NQO1 expression by sponging microRNA-494. In contrast, HOXA11-AS recruits zeste homolog 2 (EZH2) to the NQO2 promoter to suppress its expression via the trimethylation of H3K27. The upregulation of NQO1 enzymatic activity by HOXA11-AS results in the consumption of flavin adenine dinucleotide (FAD), which reduces FAD-requiring glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity and suppresses glycolysis. However, our analyses show that lactic acid fermentation levels are preserved by glutaminolysis due to increased malic enzyme-1 expression, promoting enhanced proliferation, invasion, survival, and drug resistance. In contrast, suppression of NQO2 expression reduces the consumption of NRH via NQO2 enzymatic activity and increases NAD levels, which promotes enhanced stemness and metastatic potential. In mouse tumor models, knockdown of HOXA11-AS markedly suppressed tumor growth and lung metastasis. From these findings, targeting HOXA11-AS may strongly suppress high-grade OSCC by regulating both NQO1 and NQO2.

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Section: Discussionmentioning

confidence: 98%

An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma

Nakashima

Fujiwara‐Tani

Mori

et al. 2022

IJMS

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“…Like any other type of cancers, the un-controlled growth and metathetic ability of DLBC lead to the high recurrent and mortality rate of the disease [18][19][20]. Therefore, an effective molecular therapeutic target of DLBC should be a key regulator that affect the proliferation and migration of the DLBC cells.…”

Section: Discussionmentioning

confidence: 99%

LncRNA SNHG5 can Regulate the Proliferation and Migration of Diffuse Large B Cell Lymphoma Progression via Targeting miR-181-5p/XIAP

Xing¹,

Xu²,

Liu³

et al. 2022

J. Cancer

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Background: It has been verified that long noncoding RNAs (lncRNAs) may participate in the pathogenesis of various human diseases. This study aims to investigate the roles of lncRNA SNHG5 in diffuse large B cell lymphoma (DLBC), especially the impacts of lncRNA SNHG5 on proliferation and migration of human diffuse large B cell lymphoma cells and the related mechanism. Methods: qRT-PCR analysis was carried out to examine the expression pattern of SNHG5 in DLBC tissue and adjacent normal tissue. The effect of SNHG5 on the proliferation, apoptosis, migration, and invasion of DLBC cells was detected by MTT, flow cytometry analysis, wound healing assay and transwell assay. The correlation between SNHG5, miR-181-5p and XIAP were certified by bioinformatics analysis, and dual-luciferase reporter assay. Furthermore, rescue assays were performed to analyze the effects of SNHG5-miR-181-5p-XIAP axis on the biological behaviors of diffuse large B cell lymphoma cells. Finally, the effects of SNHG5 axis on the growth of DLBC tumor was examined by in vivo analysis. Results: SNHG5 was significantly upregulated in diffuse large B cell lymphoma tissues. Knockdown of SNHG5 inhibited the proliferation, migration, and invasion of diffuse large B cell lymphoma cells in vitro and in vivo. LncRNA SNHG5 acted as a ceRNA through binding with miR-181-5p in DLBC cells. Conclusion: LncRNA SNHG5 may promote proliferation and migration of diffuse large B cell lymphoma cells via targeting miR-181-5p/XIAP.

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“…Of interest, by transferring those lncRNAs from chemoresistance GBM tissue or culture to a chemosensitive one, the chemo-sensitive tissue becomes chemoresistant [33] The lncRNA SBF2-AS1 gene is located on chromosome 11p15.1. The proliferation or invasion of many tumor types are associated with altered lncRNA SBF2-AS1 serum levels; Diffuse large B-cell lymphoma, colorectal cancer, hepatocellular carcinoma, serous ovarian carcinoma, clear cell renal cell carcinoma, esophageal squamous cell carcinoma, and lung cancer are associated with increased SBF2-AS1 serum levels [109][110][111][112][113][114][115], while laryngeal squamous cell carcinoma [116] is associated with decreased levels. LncRNA SBF2-AS1 can indirectly alter gene expression by acting as a ceRNA.…”

Section: Long Noncoding Rnas As Serum Biomarkers For Gbm Responsivene...mentioning

confidence: 99%

“…LncRNA SBF2-AS1 can indirectly alter gene expression by acting as a ceRNA. LncRNA SBF2-AS1 binds to protective miRNAs, thus inducing tumor proliferation and invasion [109][110][111]. In contrast, lncRNA SBF2-AS1 acts as an anti-oncogene in laryngeal squamous cell carcinoma by targeting a different miRNA associated with laryngeal cancer invasion and migration [116].…”

Section: Long Noncoding Rnas As Serum Biomarkers For Gbm Responsivene...mentioning

confidence: 99%

Serum long non-coding RNAs as potential noninvasive biomarkers for glioblastoma diagnosis, prognosis, and chemoresistance

Eraky¹,

Keleş²,

Goodman³

et al. 2022

J. Integr. Neurosci.

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Gliomas are common brain tumors with a variable prognosis based on their tumor grade. With glioblastomas, the prognosis is usually unfavorable. Thus, having accurate and rapid methods for their diagnosis and follow-up are essential for rapid discovery of the tumor and to protect patients from unnecessary procedures. Some glioma cases are challenging since there is a limited ability to differentiate between gliomas, recurrent glioblastomas, and single metastatic lesions. Monitoring treatment responses and follow-ups can also be challenging. While both radiological and serological markers have been identified that can aid diagnosis and assess therapies, a particularly promising new class of serological markers are long non-coding RNAs. Long non-coding RNAs are a relatively recently discovered class of regulatory RNA molecules that play critical roles in many cellular and physiological processes. The potential role that long non-coding RNAs play with glioma pathogenic processes is not fully understood. In this literature review, we highlight the potential for long noncoding RNAs to be used as serum biomarkers in glioblastoma patients, including their potential to serve as non-invasive, easy to use, and rapid diagnostic or prognostic indicators.

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LncRNA SBF2-AS1 Promotes Diffuse Large B-Cell Lymphoma Growth by Regulating FGFR2 via Sponging miR-494-3p

Cited by 12 publications

References 28 publications

An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma

An Axis between the Long Non-Coding RNA HOXA11-AS and NQOs Enhances Metastatic Ability in Oral Squamous Cell Carcinoma

LncRNA SNHG5 can Regulate the Proliferation and Migration of Diffuse Large B Cell Lymphoma Progression via Targeting miR-181-5p/XIAP

Serum long non-coding RNAs as potential noninvasive biomarkers for glioblastoma diagnosis, prognosis, and chemoresistance

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