The EGFR rs2233947 polymorphism is associated with lung cancer risk: a study from Jordan

Bashir, Nabil; Morad, Farah R.; Khabour, Omar F.; Alfaqih, Mahmoud A.; Khassawneh, Basheer

doi:10.18388/abp.2019_2781

Cited by 2 publications

(3 citation statements)

References 40 publications

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“…Association studies based on haplotype analysis of several SNPs are believed to have more statistical power than those based on individual SNPs (Bashir et al, 2019;Bader, 2001). Herein, we carried haplotype analysis of both SNPs in the RETN gene that were also examined individually for their association with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Association of RETN +299(G>A) polymorphism with type two diabetes mellitus

et al. 2021

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The global prevalence of type-two diabetes mellitus (T2DM) makes it a disease of public health concern. T2DM is strongly linked with insulin resistance caused by increased levels of visceral fat. Visceral fat secretes several adipocytokines that regulate body metabolism. Resistin is one of these adipocytokines which is encoded by the RETN gene. Herein, we tested the association of the RETN +299(G>A) and −420(C>G) single nucleotide polymorphisms (SNPs) with T2DM. T2DM patients (n=282) and healthy subjects (n=125) were included in the study. Subjects with metabolic syndromes other than diabetes were excluded. Genotyping of subjects was performed using PCR-RFLP. The +299(G>A) SNP was associated with T2DM (P=0.038). The AA genotype was higher in T2DM (17%) compared to controls (8%) with an odd ratio of 2.16 and 95% CI of 1.34 to 4.56. With respect to −420(C>G) SNP, no significant association was found with the risk of T2DM (P=0.128). The haplotype analysis of the examined SNPs indicated that the CA haplotype of the −420 and +299 SNPs in RETN was associated with T2DM risk (P=0.004; odd ration 4.0, 95% CI: 1.56–10.0). In conclusion, the present findings suggest a role of the RETN locus in modulating the risk of T2DM.

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Section: Discussionmentioning

confidence: 99%

Association of RETN +299(G>A) polymorphism with type two diabetes mellitus

et al. 2021

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“…The findings can be explained by the functional importance of these SNPs, many of them leading to an increase in the pathway activity, and, in the end, promoting the progression of the malignancy [21,39,40]. [23][24][25][26][27][28], glioma [29][30][31][32][33][34], lung cancer [38][39][40][41][42], breast cancer [36,37], cervical cancer [45], and head and neck cancer [46]. EGF is important for tumor survival, progression, metastasis, and angiogenesis [19].…”

Section: Discussionmentioning

confidence: 99%

“…This SNP is located in the exon 25 and does not produce an amino acid modification. The A allele is protective for the development of lung cancer [38].…”

Section: Epidermal Growth Factor (Egf) Signaling Pathway and Lung Cancermentioning

confidence: 99%

The Polymorphisms of Epidermal Growth Factor-driven Signaling and Cancer Pathogenesis

2021

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Background: Epidermal growth factor (EGF) is a stimulating protein for cell proliferation and differentiation. An amplification of its signaling pathway has been frequently reported in numerous malignant tumors. Specific polymorphisms of the genes encoding proteins involved in this cellular pathway may constitute risk factors for carcinogenesis. The aim of this study was to identify the most relevant polymorphisms of EGF and their signaling pathways and their relation to carcinogenesis. Methods: The study included 40 full-text articles published between January 2010 and May 2020, extracted from PubMed, Scopus, Web of Science, and Science Direct databases in May 2020, using the following keywords: EGF OR epidermal growth factor AND polymorphism AND cancer OR neoplasia OR tumor. Results: We identified relevant polymorphisms of the EGF signaling pathway that were involved in the development and progression of hepatocellular carcinoma, esophageal cancer, gastric cancer, colorectal cancer, glioma, lung cancer, breast cancer, cervical cancer, and head and neck cancer. Rs4444903 variants have been widely studied and the association with numerous tumors has been confirmed by multiple studies. Other frequently investigated polymorphisms are –191C/A and –216G>T. Conclusion: The polymorphisms of EGF signaling pathway have been widely studied in connection to various malignancies. Some predisposing variants are common in different forms of cancer. These polymorphisms might be general risk factors for carcinogenesis.

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The EGFR rs2233947 polymorphism is associated with lung cancer risk: a study from Jordan

Cited by 2 publications

References 40 publications

Association of RETN +299(G>A) polymorphism with type two diabetes mellitus

Association of RETN +299(G>A) polymorphism with type two diabetes mellitus

The Polymorphisms of Epidermal Growth Factor-driven Signaling and Cancer Pathogenesis

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