Abstract: Administration of natural antioxidants has been used to protect against nephrolithiasis. Urolithiasis was induced by ethylene glycol (EG) in Wistar rats. For 4 weeks, group 1 (control) was fed with a standard commercial diet. Group 2 received the same diet with 0.75% of EG. Group 3 received EG plus the diet and water added with antioxidant nutrients and lime juice as the dietary source of citrate (EG + AX). Group 4 same as group 3 with no EG in water. For 8 weeks, group 5 was fed the standard diet wit… Show more
“…Our results showed that EG causes the formation of stones in all parts of kidney (cortex, medulla, and para cortex [juxtamedulla]). Th ese results are consistent with other recent studies (Naghii et al 2015;Kandhare et al 2015;Shukla et al 2014;Cho et al 2014). Th e main mechanism of stone formation following administration of EG is related to EG metabolism pathway.…”
Section: Discussionsupporting
confidence: 92%
“…It immediately binds to Calcium in tissues and urinary tract and forms kidney stones (Atakan et al 2007). Results of Naghii et al (2015) showed that two other mechanisms that contribute to the stone formation include elevated androgen levels in plasma following administration of EG as well as oxidative stress in the kidney that causes apoptosis in renal tubular epithelial cells and this process is one of the most important factors in kidney stone cascade event.…”
Section: Discussionmentioning
confidence: 99%
“…Th erefore, the results obtained in the group EG+Vit E may be due to the antioxidant eff ects of this substance. It is reported that Antioxidants prevent the formation of kidney stones by reducing plasma androgen markers (Naghii et al 2015). Antioxidant supplement can protect kidney tubules cell membrane, thus leading to prevent stone formation (Th amilselvan et al 1997).…”
Section: Discussionmentioning
confidence: 99%
“…Ethylene glycol (EG: 1,2-ethanediol, ethane-1,2-diol) is a substance that causes oxidative stress in the kidney and eventually stone formation. It is toxic in its pure form and colorless, odorless, and sweet tasting substance (Naghii et al 2015). Its main industrial use is as an antifreezer for cars and air conditioners.…”
Efficient effect of boron and Vit E supplements, separately and in combination, has a complimentary effect in protection against the formation of kidney stones, probably by decreasing oxidative stress.
“…Our results showed that EG causes the formation of stones in all parts of kidney (cortex, medulla, and para cortex [juxtamedulla]). Th ese results are consistent with other recent studies (Naghii et al 2015;Kandhare et al 2015;Shukla et al 2014;Cho et al 2014). Th e main mechanism of stone formation following administration of EG is related to EG metabolism pathway.…”
Section: Discussionsupporting
confidence: 92%
“…It immediately binds to Calcium in tissues and urinary tract and forms kidney stones (Atakan et al 2007). Results of Naghii et al (2015) showed that two other mechanisms that contribute to the stone formation include elevated androgen levels in plasma following administration of EG as well as oxidative stress in the kidney that causes apoptosis in renal tubular epithelial cells and this process is one of the most important factors in kidney stone cascade event.…”
Section: Discussionmentioning
confidence: 99%
“…Th erefore, the results obtained in the group EG+Vit E may be due to the antioxidant eff ects of this substance. It is reported that Antioxidants prevent the formation of kidney stones by reducing plasma androgen markers (Naghii et al 2015). Antioxidant supplement can protect kidney tubules cell membrane, thus leading to prevent stone formation (Th amilselvan et al 1997).…”
Section: Discussionmentioning
confidence: 99%
“…Ethylene glycol (EG: 1,2-ethanediol, ethane-1,2-diol) is a substance that causes oxidative stress in the kidney and eventually stone formation. It is toxic in its pure form and colorless, odorless, and sweet tasting substance (Naghii et al 2015). Its main industrial use is as an antifreezer for cars and air conditioners.…”
Efficient effect of boron and Vit E supplements, separately and in combination, has a complimentary effect in protection against the formation of kidney stones, probably by decreasing oxidative stress.
“…) . (Tugcu et al, 2008;Parmar et al, 2012;Makasana et al, 2014;Naghii et al, 2014;Kumar et al, 2015 (Giebisch, 2004;Goff, 2004;Grunberg et al, 2006;Grunberg et al, 2011;Constable et al, 2013;) . (Aviram et al, 2002;Touhami et al, 2007 (Karadi et al, 2006;Celik et al, 2007) .…”
The aim of this study is to determine the protective effect of both pomegranate juice Punica granatum and Citrus juice Citrus limon in preventing the newly formed kidney stone induced by ethylene glycol in local male rabbits Oryctolagus cuniculus,which was expressed by monitoring renal functions, study of the effect of oxidative stress induced by ethylene-glycol, in addition to microscopic examination of the kidney tissue. In the current study 30 male rabbits were used ranging in age from (8-10) months, and weight (1500-2000) g, divided into 6 random groups, 5 Rabbit / group, as follows:The first group : was given water and the standard diet as a control group, Group 2: was given ethylene glycol at a concentration of 1 ml / kg body weight, Group 3: was given the Pomegranate juice with a concentration of 6 ml / kg body weight, Group 4: was given the lemon juice at a concentration of 4 ml / kg body weight, Group 5: was given the ethylene glycol at a concentration of 1 ml / kg in addition to Pomegranate juice with a concentration of 6 ml / kg body weight, Group 6: was given the ethylene-glycol at a concentration of 1 ml / kg body weight as well as lemon juice at a concentration of 4 ml / kg body weight, for 30 days and two doses daily in the morning and evening. Results showed the induction of calculi by ethylene glycol in local male rabbits which resulted in negative effects in the biochemical parameters, which was a significant increase at a potential level (P≤ 0.05) in the concentration of urea, creatinine, uric acid, malodialdehyde MDA, magnesium, potassium while the concentration of glutathione GSH and calcium decreased when treated with ethylene glycol compared with control, Tissue sections of the kidney showed a clear deposition of calcium oxalate crystals in renal tissues with a damage of the epithelial tissue lining of the renal tubules with necrosis, degeneration and enlargement of renal tubules due to deposition of these crystals. The treatment of local male rabbits with pomegranate and lemon juice each alone lead to positive effects in biochemical parameters for kidney, the results also showed a non significant decrease in the level of glutathione and a significant decrease in level of blood serum MDA compared with control. Treatment of ethylene glycol with pomegranate and lemon juices alone lead to positive effects in biochemical parameters and studied electrolytes. Tissue sections of the kidney showed decrease in deposition of calcium oxalate crystals in the renal tubules and the damage caused by ethylene glycol in epithelial tissue lining of the kidney.
To evaluate protective effects of Tutukon, a plant derived herbal product, on the development of rat urolithiasis model. A total of 45 rats were divided into three groups namely; Group 1 (control group; drinking water + zinc disk), Group 2 (0.5 % ethylene glycol [EG] to drinking water + zinc disk) and Group 3 (study group-0.5 % EG + Tutukon + zinc disk). Moreover, zinc disks were placed into bladder of rats to serve as a nidus for stone development. Five rats from each group were killed at the end of the 1st, 2nd and 4th week. The level of bladder inflammation, the disk weights and the urine oxalate, calcium and pH values and were evaluated and compared. The inflammation scores of the pathological evaluation were not significantly different among three groups. At the end of the 28th day, weights of the zinc disks were significantly higher in Group 2 (394.4 ± 41.2) when compared to Group 1 (1517.5 ± 367.3) and Group 3 (386.2 ± 26.9) (p = 0.016). The disk weights increased gradually at 7th, 14th and 28th days in Group 1 (p = 0.018) and Group 2 (p = 0.009) while remained stable in Group 3 (p = 0.275). Urine calcium levels were not affected among three groups throughout the study period. At the end of the 28th day, while the urine oxalate levels of rats in Group 1 was lower than that of both Group 2 (p = 0.046) and Group 3 (p = 0.008); Group 2 and Group 3 had similar oxalate excretion levels (p = 0.701). However, the difference was not significant. Tutukon seems to decrease stone deposition on zinc disks implanted in the bladder of rats. The exact mechanism of this preventive effect is, however, not well understood.
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