The efficacy and plasma profiles of abamectin plus levamisole combination anthelmintics administered as oral and pour‐on formulations to cattle

Leathwick, Dave M.; Miller, C.M.; Sauermann, Christian W.; Candy, P.M.; Ganesh, Siva; Fraser, Karl; Waghorn, T.S.

doi:10.1016/j.vetpar.2016.07.031

Cited by 28 publications

(20 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Their contractile impact towards gut smooth muscle observed in vivo is consistent with our findings obtained from experiments performed on bovine isolated abomasum and duodenum strips (Figures , and ). As expected, all three pharmaceuticals enhanced the reactivity of gastrointestinal specimens to ACh when tested in a concentration range of 0.1–100 μM, that is, in doses that correspond at least partially to the concentrations of the drugs measured in cows’ blood (Anderson, Neff‐Davis, Davis, & Bass, ; EMEA ; Rantala et al., ; Leathwick et al., ). Besides, bearing in mind dose considerations for in vitro – in vivo extrapolation (IVIVE) and generally lower sensitivity of in vitro assays in comparison with in vivo systems (Groothuis et al., ; Wetmore, ), the study included additionally the use of all pharmaceuticals in the concentrations that exceeded 10–100 times their concentrations measured in cows.…”

Section: Discussionsupporting

confidence: 62%

Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility—in vitro study

Mendel

Chłopecka

Dziekan

et al. 2017

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

Continued ingestion of plant secondary metabolites by ruminants can provoke pharmacological interactions with pharmaceutical agents used in animals. As some drugs and phytocompounds affect smooth muscle activity, the aim of this study was to verify the possible interaction between selected pharmaceutical agents and plant secondary metabolites towards bovine gastrointestinal motility. The interactions between phytocompounds-apigenin, quercetin, hederagenin, medicagenic acid-and medicines-erythromycin, flunixin meglumine and levamisole-were evaluated on bovine isolated abomasal and duodenal specimens obtained from routinely slaughtered cows. The obtained results confirmed the contractile effect of all three drugs used solely. Hederagenin and medicagenic acid (0.001 μM) enhanced the contractile effect of levamisole. Hederagenin additionally increased the impact of erythromycin. Both saponins (100 μM) showed synergistic effects with all tested pharmaceuticals. Apigenin and quercetin (0.001 μM) intensified the contractile response induced by erythromycin and levamisole. Moreover, both flavonoids (100 μM) showed an antagonistic interaction with all tested drugs which in that situation were devoid of the prokinetic effect. To conclude, plant metabolic metabolites such as saponins and flavonoids are potent modifiers of the effect of drugs towards gut motility. The synergy observed between phytocompounds and selected medicines can be beneficial in the treatment of cows with hypomotility disorders.

show abstract

Section: Discussionsupporting

confidence: 62%

Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility—in vitro study

Mendel

Chłopecka

Dziekan

et al. 2017

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

show abstract

“…This effect has been demonstrated in some trials performed with sheep and treated with an anthelmintic combination (Anderson, Martin, & Jarret, ; Anderson et al., ; Entrocasso et al., ; Mckenna, ). Although published information in cattle is scarce, some preliminary results indicate that the combination of macrocyclic lactones and LEV was highly effective in minimizing the survival of resistant nematodes (Leathwick et al., ; Mason & McKay, ; Smith, ). Furthermore, the combination IVM + RBZ obtained significantly higher efficacy against IVM‐resistant Haemonchus spp.…”

Section: Discussionmentioning

confidence: 99%

“…Although limited information is available on the PK interactions between nematodicidal drugs in cattle, Leathwick et al (2016) found that abamectin (ABM) bioavailability was significantly greater after the oral ABM + LEV combination than after the single-active oral administration in cattle. In contrast, the same study did not find any difference in LEV plasma concentrations between single and combined treatments (Leathwick et al, 2016). Similarly, no significant PK changes were observed in the current study for LEV after their s.c. co-administration with RBZ in calves.…”

Section: Ostertagia 28%mentioning

confidence: 99%

Pharmaco‐parasitological evaluation of the ricobendazole plus levamisole nematodicidal combination in cattle

Cantón

Ceballos

Dominguez

et al. 2017

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

The goals of the current study were to evaluate the potential pharmacokinetic (PK) interactions and the clinical efficacy occurring after the subcutaneous (s.c.) administration of ricobendazole (RBZ) and levamisole (LEV) given both separately and coadministered to calves naturally infected with susceptible gastrointestinal nematodes.The clinical efficacy was shown in two seasons, winter and spring, with predominance of different nematode populations. Groups of 15 calves were treated with RBZ alone, LEV alone and RBZ + LEV combination, and an untreated group was kept as a Control.RBZ and LEV plasma concentrations were quantified by HPLC. The clinical efficacy was determined by the faecal egg count reduction test. RBZ and LEV have similar plasma persistence, being detected in plasma over 24 hr post-treatment. No PK interactions were observed after the combined treatment, with similar PK parameters (p > .05) obtained for the single-drug and the combination-based strategy. In winter, the observed clinical efficacies were 96%, 99% and 100% for groups treated with RBZ, LEV and RBZ + LEV, respectively; however, in spring, the efficacies were 95%, 93% and 96% for the same groups. Remarkably, the combination was the only treatment that achieved 100% clinical efficacy against both Haemonchus spp and Ostertagia spp in winter; but the increased presence of Ostertagia spp. in spring (28% in untreated group) determined a tendency to reduced efficacies compared to winter time (only 10% of Ostertagia spp. in untreated group), even for the combined treatment. Overall, in a scenario where the nematode population is susceptible, the RBZ + LEV treatment may be a valid combination in cattle to delay the development of resistance, especially in winter when this combination achieved 100% of efficacy. Thus, selection of anthelmintic resistance will never occur. In fact, this is one of the greatest challenges for the whole cattle production system: to be one step ahead of anthelmintic resistance.

show abstract

“…Abamectin is registered as an acaricide/insecticide in more than 50 countries. This compound is important in animal health and crop protection [21][22][23]. It can be stored for many months maintaining its biological properties and it can be also used as seed treatment to protect plants, in the initial growing phase, from plant parasitic nematodes and insects which attack root systems [24].…”

Section: Introductionmentioning

confidence: 99%

Abamectin Efficacy on the Potato Cyst Nematode Globodera pallida

Sasanelli

Toderaş

Veronico

et al. 2019

Plants

View full text Add to dashboard Cite

The potato cyst nematode Globodera pallida is a major pest of the potato crop. Abamectin is a biological pesticide showing high nematicide activity, but its efficacy to control G. pallida has not been investigated to date. In this study, combination of different abamectin concentrations ranging from 1.125 to 36 µg/mL x exposure times from 24 to 384 h were tested on the nematode in a hatching test. Abamectin induced mortality with LD50 value in the range of 13.23 (after 24 h) to 2.90 µg/mL (after 384 h). A glasshouse experiment was also performed in pots filled with soil infected with G. pallida in the presence of sprouted potato tubers cultivar “Spunta”. Abamectin at 4.5, 9.0, 18.0 and 36.0 µg/mL was used in comparison with nematicide fosthiazate. The doses of 18 and 36 µg/mL significantly reduced number of eggs, juveniles, cyst/g soil and reproduction rate in comparison to both untreated control and fosthiazate treatment. Soil applications of abamectin provided significant G. pallida control with LD50 and LD99.9 of 14.4 and 131.3 µg/mL, respectively. These results indicate the efficacy of abamectin to control G. pallida on potato crops and its potential use in organic agriculture or in an integrated pest management program.

show abstract

The efficacy and plasma profiles of abamectin plus levamisole combination anthelmintics administered as oral and pour‐on formulations to cattle

Cited by 28 publications

References 33 publications

Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility—in vitro study

Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility—in vitro study

Pharmaco‐parasitological evaluation of the ricobendazole plus levamisole nematodicidal combination in cattle

Abamectin Efficacy on the Potato Cyst Nematode Globodera pallida

Contact Info

Product

Resources

About