The Effects on the Cardiovascular System of Fluids Administered Intravenously in Man. I. Studies of the Amount and Duration of Changes in Blood Volume

Cardiovascular, Renal, and General Effects of Large, Rapid Plasma Infusions in Convalescent Men 1

“…There have been numerous studies of the effects of the intravenous injection of large amounts of fluids into animals (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) and into man (17)(18)(19)(20)(21)(22)(23)(24)(25). Eyster and Middleton (17) found that injection of about 1%o of body weight of blood in 10-14 minutes into cases of primary anemia caused transitory changes in blood and venous pressures and insignificant alterations in heart size.…”

“…of saline in 30 minutes, noting rise of venous pressure followed by a very slow fall, and failure of the venous pressure to subside quickly after infusion has been used by Richards, Caughey, et al (19) as a test for heart failure. Gilligan et al (20,21) gave saline and/or glucose in varying concentrations in amounts up to 1500 cc. at rates up to 71 cc.…”

The Effects on the Cardiovascular System of Fluids Administered Intravenously in Man. Iv. The Lung Volume and Pulmonary Dynamics

“…(Received for publication January 20, 1942) Earlier studies from this laboratory (1,2,3) have shown that the intravenous administration of 500 to 1500 cc. of fluids, at rates ranging from 9 to 125 cc.…”

“…Immediately following this, the reserve and complemental airs were measured and then the second of the postinfusion estimations of the lung volume was made. The hematocrit and plasma protein concentration were measured as in previous studies (1,2,3). Calculations of the changes in blood volume were based on methods previously described (1).…”

“…The hematocrit and plasma protein concentration were measured as in previous studies (1,2,3). Calculations of the changes in blood volume were based on methods previously described (1).…”