Cardiovascular, Renal, and General Effects of Large, Rapid Plasma Infusions in Convalescent Men 1

Wilson, J.; Harrison, Clinton R.; Taylor, Leonard L.; Knight, C. E.; Haines, W.

doi:10.1172/jci102252

Cited by 23 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The magnitude of the pulmonary pressure change in the presented data is greater than that in the peripheral veins and right auricle. Plasma protein infusions were previously reported to produce only transient increase in peripheral venous and arterial pressures (8), and the absence of pressure change was ascribed to generalized vasodilation which accommodated the expanded volume; however, these studies with dextran indi- The data of Doyle, Wilson, Estes and Warren (9) and the findings of this study showed that comparable changes occur in pulmonary arterial and pulmonary wedge pressure. These data suggest that the left atrial, and possibly the left ventricular diastolic, pressure is elevated following plasma volume expansion.…”

Section: Discussioncontrasting

confidence: 63%

Further Observations on the Hemodynamic Effect of Plasma Volume Expansion by Dextran1

Fleming¹,

Bloom²

1957

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 63%

Further Observations on the Hemodynamic Effect of Plasma Volume Expansion by Dextran1

Fleming¹,

Bloom²

1957

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…If, for example, GFR remained constant, while renal blood flow increased (i.e., reduced filtration fraction), peritubular hydrostatic pressures would be transiently elevated relative to the intratubular pressure, the tubule would be narrowed, and reabsorption would be proportionately reduced. Since filtration fraction diminishes in saline diuresis (19,20), it is reasonable to conclude that the resultant fall in postglomerular COP and rise in postglomerular blood flow relative to the GFR contribute to the fall in tubular volume per unit GFR observed in the present studies.…”

Section: Discussionsupporting

confidence: 47%

The Mechanism of Suppression of Proximal Tubular Reabsorption by Saline Infusions*

Rector¹,

Sellman²,

Martínez‐Maldonado³

et al. 1967

J. Clin. Invest.

115

View full text Add to dashboard Cite

Summary. The mechanism by which expansion of extracellular fluid volume with isotonic saline suppresses reabsorption in the proximal tubule was studied in rats by examining the relations among glomerular filtration rate (GFR), absolute and fractional reabsorption of filtrate, intrinsic reabsorptive capacity (rate of reabsorption per unit tubular volume), transit time, and tubular volume.Saline infusions reduced the per cent of the glomerular filtrate reabsorbed in the proximal tubule from 50% during antidiuresis to 25% during saline diuresis. The suppression of proximal reabsorption was the result of two factors: 1) a 30% reduction of intrinsic reabsorptive capacity, and 2) a 26% reduction of tubular volume per unit GFR.GFR invariably rose during saline diuresis. However, prevention of the rise in GFR by aortic clamping had no effect on either the inhibition of intrinsic reabsorptive capacity or the reduction in tubular volume per unit GFR produced by saline infusions. Expansion of extracellular fluid volume with isotonic saline, therefore, depressed intrinsic reabsorptive capacity and tubular volume per unit GFR by some mechanism completely independent of GFR.The effects of furosemide administration were contrasted with those of saline infusions. Furosemide inhibited intrinsic reabsorptive capacity by 40% but had no significant effect on proximal fractional reabsorption. The failure to suppress fractional reabsorption was the consequence of a disproportionate rise in tubular volume (relative to GFR) that was sufficient to completely overcome the inhibition of intrinsic reabsorptive capacity. Inhibition of intrinsic reabsorptive capacity alone, therefore, will not result in a net suppression of reabsorption of filtrate in the proximal tubule. We concluded that, although intrinsic reabsorptive capacity was inhibited during saline diuresis, the critical factor responsible for translating this inhibition into effective net suppression of proximal reabsorption was the observed reduction in tubular volume per unit GFR. IntroductionThe diuresis induced by expanding extracellular fluid (ECF) volume with isotonic saline is due in part to a decrease in the fraction of the glomerular filtrate reabsorbed in the proximal convoluted tubule (1, 2). However, the mechanism by which saline infusions depress fractional reabsorption in the proximal tubule has not been examined.Previous studies in our laboratory (3, 4) explored the factors controlling fractional reabsorption in the proximal tubule under conditions in which glomerular filtration rate (GFR) was varied but ECF volume was kept constant. We found that the absolute rate of reabsorption during both aortic constriction and increased ureteral pressure was a direct function of tubular volume. When GFR was acutely reduced by constricting the aorta, tubular volume decreased proportionately to GFR; this resulted in a proportionate decrease in the reabsorptive rate, thereby maintaining constant fractional reabsorption. In contrast, when GFR was decreased by acutely elevating ur...

show abstract

“…Both experimental and clinical studies (28)(29)(30)(31)(32)(33) have demonstrated that hypervolemia may be responsible for significant changes in cardiac hemodynamics. Recently, Eichna, Farber, Berger, Rader, Smith, and Albert (33) have described patients in whom hypervolemia was associated with increased cardiac output and decreased A-V oxygen difference and in whom a congested circulatory state existed in the absence of primary myocardial disease.…”

Section: Pressuresmentioning

confidence: 99%

Hemodynamics at Rest and During Exercise in Normal Pregnancy as Studied by Cardiac Catheterization 12

Bader¹,

Bader²,

Rose³

et al. 1955

J. Clin. Invest.

243

View full text Add to dashboard Cite

Cardiovascular, Renal, and General Effects of Large, Rapid Plasma Infusions in Convalescent Men 1

Cited by 23 publications

References 36 publications

Further Observations on the Hemodynamic Effect of Plasma Volume Expansion by Dextran1

Further Observations on the Hemodynamic Effect of Plasma Volume Expansion by Dextran1

The Mechanism of Suppression of Proximal Tubular Reabsorption by Saline Infusions*

Hemodynamics at Rest and During Exercise in Normal Pregnancy as Studied by Cardiac Catheterization 12

Contact Info

Product

Resources

About