The effects of vitamin D supplementation on indices of glycemic control in Iranian diabetics: A systematic review and meta-analysis

Sahebi, Reza; Rezayi, Majid; Emadzadeh, Maryam; Salehi, Maryam; Tayefi, Maryam; Parizadeh, Seyed Mostafa; Behboodi, Negin; Rastgar‐Moghadam, Azam; Khorassani, Jasmin Kharazmi; Khorassani, Sara Kharazmi; Mohammadi, Abdorreza; Ferns, Gordon A.; Rezayi, Majid

doi:10.1016/j.ctcp.2018.12.009

Cited by 20 publications

(12 citation statements)

References 80 publications

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“…[24], which showed that there was no significant change in HbA1C (P= 0.5) in VD supplementation for 12 weeks. It showed a significant decrease in HOMA-IR about insulin resistance, which is the main parameter in our study, and this is consistent with other studies that showed significant improvement in insulin resistance after VD administration [17,20]. Bazaar et al [19] also demonstrated that HOMA-IR was significantly reduced (P= 0.007) after 8 weeks of VD intervention.…”

Section: Discussionsupporting

confidence: 92%

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Investigation of the clinical outcomes of long-term vitamin D supplementation in Egyptian Type 2 Diabetes Mellitus patients

Elnaggar

Tolba

Halawa

et al. 2021

Archives of Pharmaceutical Sciences Ain Shams University

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Diabetes mellitus (DM) is a group of metabolic disorders that are characterized by a chronic condition of hyperglycemia due to insulin secretion defects, insulin action, or both. The predominant form of diabetes is Type 2 Diabetes Mellitus (T2DM), which accounts for 90% of all DM cases. Studies showed that vitamin D (VD) plays an important role in changing the risk of T2DM, particularly among diabetic patients with insulin resistance. A novel association has recently been proposed between insulin resistance and vitamin D deficiency. In the current research, we investigated the association between hypovitaminosis D and T2DM. Also, we studied the effect of vitamin D supplementation on glycemic status, oxidative stress status, and inflammatory markers in T2DM patients. Forty T2DM patients with hypovitaminosis D were assessed for glycemic, inflammatory, and antioxidant parameters. After 6 months of VD supplementation for the intervention group of patients (n= 20), there was a significant improvement in VD level, Homeostatic model assessment of insulin resistance (HOMA-IR), Fasting blood glucose (FBG), glycated hemoglobin (HbAIC), serum insulin, interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), total antioxidant capacity (TAC) and malondialdehyde (MDA). In conclusion, as there was a significant improvement in glycemic, inflammatory, and oxidative stress parameters in type 2 diabetes mellitus patients, vitamin D supplementation has a promising effect on the treatment of type 2 diabetes.

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Section: Discussionsupporting

confidence: 92%

“…Sahebi et al [20] showed that in individuals with T2DM, VD supplementation was associated with significant improvement in FBG (P= 0.001). Our outcome, however, is contradictory to other studies that show that FBG is not significantly improved by VD supplementation [5, 7, 21, 22].…”

Section: Discussionmentioning

confidence: 99%

Investigation of the clinical outcomes of long-term vitamin D supplementation in Egyptian Type 2 Diabetes Mellitus patients

Elnaggar

Tolba

Halawa

et al. 2021

Archives of Pharmaceutical Sciences Ain Shams University

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“…An exploration of the effects of different types of nutritional supplementation on glucose metabolism indicated that such supplementation can not only be used as adjunctive therapies to nutritional treatment but also appropriately meet the nutritional needs of pregnant women and fetuses. At present, studies have shown the effectiveness of vitamin D and omega-3 [36][37][38] in improving glucose metabolism. Direct meta-analysis studies mostly analyze the effects of supplementation with a single nutrient compared with placebo, and few studies have compared the effects of different nutritional strategies.…”

Section: Discussionmentioning

confidence: 99%

Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis

Jin

Sha

Dong

et al. 2020

Journal of Diabetes Research

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Background. Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy, and nutritional therapy is the basis of GDM treatment. However, the effects of different forms of nutritional supplementation on improving gestational diabetes are uncertain. Objective. We conducted a network meta-analysis to evaluate the effects of supplementation with different nutrients on glucose metabolism in women with GDM. Methods. We conducted a literature search using PubMed, EMBASE, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing the differences between different nutritional strategies in women with GDM. The Cochrane tool was used to assess the risk of bias. Pairwise meta-analysis and network meta-analysis were used to compare and rank the effects of nutritional strategies for the improvement of fasting plasma glucose (FPG), serum insulin, and homeostasis model assessment-insulin resistance (HOMA-IR). Results. We included thirteen RCTs with a total of 754 participants. Compared with placebo, omega-3, magnesium, vitamin D, zinc, and probiotics were more beneficial for improving FPG, serum insulin, and HOMA-IR. Network analysis showed that vitamin D supplementation was superior to omega-3 (-3.64 mg/dL, 95% CI: -5.77 to -1.51), zinc (-5.71 mg/dL, 95% CI: -10.19 to -1.23), probiotics (-6.76 mg/dL, 95% CI: -10.02 to -3.50), and placebo (-12.13 mg/dL, 95% CI: -14.55 to -9.70) for improving FPG. Magnesium supplementation was more beneficial for decreasing serum insulin compared with probiotics (-5.10 μIU/mL, 95% CI: -9.32 to -0.88) and placebo (-7.80 μIU/mL; 95% CI-11.95, -3.65). Vitamin D was more effective than probiotics (-0.99, 95% CI: -1.84 to -0.14) and placebo (-1.80, 95% CI: -2.45 to -1.16) for improving HOMA-IR. Conclusion. Vitamin D supplementation significantly reduced FPG and regulated HOMA-IR. Magnesium supplementation was superior in decreasing serum insulin than supplementation with other nutrients. Nutrient supplementation seemed to have an effect on glucose homeostasis maintenance in patients with GDM and may be considered an adjunctive therapy.

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“…Some studies showed that vitamin D supplementation had beneficial effects on glycemia in women with GDM [ 18 ]. However, other studies showed that vitamin D supplementation had no significant effect on fasting plasma glucose (FPG) or fasting blood glucose (FBG) level in patients with GDM [ 21 ]. The role of selenium in glucose control in GDM was also inconsistent.…”

Section: Introductionmentioning

confidence: 99%

The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus

Cai

Pan

et al. 2021

BMC Endocr Disord

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Background The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus (GDM) have not been well established. We conduct a meta-analysis to evaluate the effects of vitamin and mineral supplementation on glycemic control, inflammation and oxidative stress for women with GDM. Methods A systematic search of randomized controlled trials (RCTs) was conducted from PubMed, Embase, Web of Science and Cochrane Library up to July, 2020. Various results were pooled by using Review manager 5.3 and Stata 12.0. Mean difference (MD) with 95% confidence interval (CI) was estimated. Heterogeneity between studies was assessed by I-squared (I2) tests. Results Six hundred ninety-eight patients from 12 trials were included in our meta-analysis. Magnesium, zinc, selenium, calcium, vitamin D and E (alone or in combination) were found to significantly improve glycemic control in women with GDM compared to those receiving placebos: fasting plasma glucose (FPG) (MD = - 9.02; 95% CI: - 12.09, - 5.96; P < 0.00001), serum insulin (MD = - 4.33; 95% CI: - 5.35, - 3.32; P < 0.00001), homeostasis model assessment-insulin resistance (HOMA-IR) (MD = - 1.34; 95% CI: - 1.60, - 1.07; P < 0.00001), and homeostasis model of assessment for β cell function (HOMA-B) (MD = - 15.58; 95% CI: - 23.70, - 7.46; P = 0.0002). Vitamin and mineral supplementation was found to attenuated inflammation and oxidative stress through decreasing high-sensitivity C-reactive protein (hs-CRP) (MD = - 1.29; 95% CI: - 1.82, - 0.76; P < 0.00001), malondialdehyde (MDA) (MD = - 0.71; 95% CI: - 0.97, - 0.45; P < 0.00001), and increasing total antioxidant capacity (TAC) (MD = 45.55; 95% CI: 22.02, 69.08; P = 0.0001). Conclusions This meta-analysis shows that vitamin and mineral supplementation significantly improved glycemic control, attenuated inflammation and oxidative stress in women with GDM.

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The effects of vitamin D supplementation on indices of glycemic control in Iranian diabetics: A systematic review and meta-analysis

Cited by 20 publications

References 80 publications

Investigation of the clinical outcomes of long-term vitamin D supplementation in Egyptian Type 2 Diabetes Mellitus patients

Investigation of the clinical outcomes of long-term vitamin D supplementation in Egyptian Type 2 Diabetes Mellitus patients

Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis

The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus

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