Investigation of the clinical outcomes of long-term vitamin D supplementation in Egyptian Type 2 Diabetes Mellitus patients

Abstract

Diabetes mellitus (DM) is a group of metabolic disorders that are characterized by a chronic condition of hyperglycemia due to insulin secretion defects, insulin action, or both. The predominant form of diabetes is Type 2 Diabetes Mellitus (T2DM), which accounts for 90% of all DM cases. Studies showed that vitamin D (VD) plays an important role in changing the risk of T2DM, particularly among diabetic patients with insulin resistance. A novel association has recently been proposed between insulin resistance and vitamin D deficiency. In the current research, we investigated the association between hypovitaminosis D and T2DM. Also, we studied the effect of vitamin D supplementation on glycemic status, oxidative stress status, and inflammatory markers in T2DM patients. Forty T2DM patients with hypovitaminosis D were assessed for glycemic, inflammatory, and antioxidant parameters. After 6 months of VD supplementation for the intervention group of patients (n= 20), there was a significant improvement in VD level, Homeostatic model assessment of insulin resistance (HOMA-IR), Fasting blood glucose (FBG), glycated hemoglobin (HbAIC), serum insulin, interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), total antioxidant capacity (TAC) and malondialdehyde (MDA). In conclusion, as there was a significant improvement in glycemic, inflammatory, and oxidative stress parameters in type 2 diabetes mellitus patients, vitamin D supplementation has a promising effect on the treatment of type 2 diabetes.