The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus

Li, Dandan; Cai, Zhongxiang; Pan, Zhenhong; Yang, Yan; Zhang, Jingjing

doi:10.1186/s12902-021-00712-x

Cited by 15 publications

(13 citation statements)

References 44 publications

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“…In addition, combined vitamin supplementation may also have an important role in glycaemic regulation in GDM. This is consistent with the findings of Li D et al (34) that combined vitamin supplementation significantly reduced blood glucose levels and maintained glycaemic homoeostasis in GDM patients. The reason for this may be that VA can indirectly reduce insulin resistance by regulating the level of the secreted adipokine RBP4 (35, 36) , while VE regulates the level of inflammation and oxidative stress in the body and reduces lipid peroxidation, which results in the regulation of glucose and insulin levels in the body (37) .In contrast, VD increases insulin sensitivity by activating vitamin D receptors in pancreatic β -cells (38) , while promoting an increase in glucose uptake in peripheral tissues and glycogen synthesis in the liver (39) , which allows blood glucose to become homoeostatic.…”

Section: Discussionsupporting

confidence: 93%

Effect of different nutrients on blood glucose, inflammatory response and oxidative stress in gestational diabetes mellitus: a network meta-analysis

Yu,

Zhu,

Geng

et al. 2024

Br J Nutr

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We searched PubMed, Web of Science, Embase, The Cochrane Library, China Biomedical Literature Database, and other databases from inception to June 2023. The included studies were randomized controlled trials (RCTs). The studies were screened by four authors, divided into two independent pairs. A total of 18 studies were included, including 1362 patients, involving 12 intervention measures. The different nutrients had a significant effect on improving blood glucose, reducing inflammation levels, and reducing oxidative stress compared to placebo(P<0.05). Cumulative probability ranking showed that vitamin A+ vitamin D+ vitamin E ranked first in lowering fasting blood glucose [SMD=41.30, 95% CI (2.07,825.60)] and postprandial 2-hour blood glucose [SMD=15.19, 95% CI (4.16,55.53)]. In terms of insulin resistance index, the first highest probability ranking is vitamin D [SMD=5.12,95%CI(0.76,34.54)]. In terms of reducing the hs-CRP level, the first in probability ranking is VE [SMD=2.58,95%CI(1.87,3.55)]. The results of cumulative probability ranking showed that Mg+Zn+Ca+VD ranked first in reducing TNF-α [SMD=1.90,95% CI (0.40,9.08)] and IL-6 [SMD=1.83,95% CI (0.37,9.12)]. In terms of reducing MDA levels, the first ranked probability is VB1 [SMD=4.99,95%CI(1.85,13.46)]. Cumulative probability ranking results showed that Ca+VD ranked first in reducing TAC[SMD=0.66,95% CI (0.38,1.15)] and GSH [SMD=1.39,95% CI (0.43,4.56)]. In conclusion, nutritional interventions has significant effects on improving blood glucose, inflammatory levels, and oxidative stress in patients with gestational diabetes. Due to the high uncertainty in the results and differences in the number and quality of studies included, the reliability of the conclusions still needs to be validated by conducting large-sample, high-quality randomised controlled trial studies.

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Section: Discussionsupporting

confidence: 93%

Effect of different nutrients on blood glucose, inflammatory response and oxidative stress in gestational diabetes mellitus: a network meta-analysis

Yu,

Zhu,

Geng

et al. 2024

Br J Nutr

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“…Minerals are of paramount importance in order to preserve and obtain good health and their key role is supported by a significant amount of literature [ 3 ]. The crucial role of minerals shifts from helping vitamin absorption [ 4 ] and immunomodulatory effect [ 5 ] to metabolic [ 6 ] and bone metabolism [ 7 ], influencing hematological [ 8 ] and endocrine function [ 9 ]. The source of many important minerals is mainly plant-based therefore it is important to use a balanced diet to provide the adequate proportion of minerals [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study

et al. 2022

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Diabetes is expected to increase up to 700 million people worldwide with type 2 diabetes being the most frequent. The use of nutritional interventions is one of the most natural approaches for managing the disease. Minerals are of paramount importance in order to preserve and obtain good health and among them molybdenum is an essential component. There are no studies about the consumption of biofortified food with molybdenum on glucose homeostasis but recent studies in humans suggest that molybdenum could exert hypoglycemic effects. The present study aims to assess if consumption of lettuce biofortified with molybdenum influences glucose homeostasis and whether the effects would be due to changes in gastrointestinal hormone levels and specifically Peptide YY (PYY), Glucagon-Like Peptide 1 (GLP-1), Glucagon-Like Peptide 2 (GLP-2), and Gastric Inhibitory Polypeptide (GIP). A cohort of 24 people was supplemented with biofortified lettuce for 12 days. Blood and urine samples were obtained at baseline (T0) and after 12 days (T2) of supplementation. Blood was analyzed for glucose, insulin, insulin resistance, β-cell function, and insulin sensitivity, PYY, GLP-1, GLP-2 and GIP. Urine samples were tested for molybdenum concentration. The results showed that consumption of lettuce biofortified with molybdenum for 12 days did not affect beta cell function but significantly reduced fasting glucose, insulin, insulin resistance and increased insulin sensitivity in healthy people. Consumption of biofortified lettuce did not show any modification in urine concentration of molybdenum among the groups. These data suggest that consumption of lettuce biofortified with molybdenum improves glucose homeostasis and PYY and GIP are involved in the action mechanism.

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“…Apart from studies on the general healthy population, the association of vitamin D and magnesium has also been assessed among pregnant women and the pediatric age group. A meta-analysis conducted by Li et al [ 48 ] evaluated the effects of vitamin and mineral supplementation on glycemic control for women with GDM. Their findings showed that 100 mg magnesium plus 200 IU vitamin D supplementation twice a day causes a significant decrease in the FPG and HOMA-IR levels.…”

Section: Association Of Vitamin D and Magnesium In Insulin Sensitivit...mentioning

confidence: 99%

Association of vitamin D and magnesium with insulin sensitivity and their influence on glycemic control

Nik¹,

Zulkeflee²,

Rahim³

et al. 2023

World J Diabetes

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Insulin resistance increases the risk of developing diabetes, and the degree of resistance influences the glycemic control of patients with diabetes. Numerous researchers have focused on improving insulin sensitivity in order to prevent diabetes-related complications and other chronic diseases. Several studies have also linked vitamin D levels to insulin secretion and resistance, given that both vitamin D and its receptor complex play important roles in regulating pancreatic β-cells. It has been suggested that vitamin D supplementation improves vitamin D levels, but further research is needed to confirm this as neither insulin function nor glycemic control improves when vitamin D levels increase. Magnesium is a cofactor for many enzymes. Although the role of magnesium in the management of diabetes has long been evaluated, it has not yet been determined whether magnesium supplements improve insulin function. However, several researchers have found that patients with good glycemic control have high magnesium levels. Magnesium is closely related to vitamin D and is necessary for the transport and activation of vitamin D in humans. Combined supplementation with vitamin D and magnesium improves glycemic control in patients with diabetes.

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The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus

Cited by 15 publications

References 44 publications

Effect of different nutrients on blood glucose, inflammatory response and oxidative stress in gestational diabetes mellitus: a network meta-analysis

Effect of different nutrients on blood glucose, inflammatory response and oxidative stress in gestational diabetes mellitus: a network meta-analysis

Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study

Association of vitamin D and magnesium with insulin sensitivity and their influence on glycemic control

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