The effects of thorazine on learning and retention in schizophrenic patients.

Vestre, Norris D.

doi:10.1037/h0041544

Cited by 27 publications

(11 citation statements)

References 14 publications

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“…Since previous experimental work on the cognitive effects of chlorpromazine has apparently not used emotionally disturbed children as subjects, the present results will have to be compared with the most nearly similar studies with adults. The findings for the paired-associate task in the present study are in only partial agreement with those obtained from adult schizophrenics by Vestre (1961) in a study of the acquisition of nonpreferred word associations. He found a trend toward less efficient learning of the task as a whole in the chlorpromazine subjects, but this was not statistically significant.…”

Section: Discussionsupporting

confidence: 85%

“…Previous studies of the effects of chlorpromazine on cognitive processes have used adult subjects almost exclusively, and have produced somewhat inconsistent results. Chlorpromazine has been found to impair retention of verbal associations in adult schizophrenics (Vestre, 1961) and to have no effect on a serial learning task (Whitehead & Thune, 1958). Gilgash (1961) reported improvement in IQ scores in adult catatonics following chlorpromazine, while Gibbs, Wilkens, and Lauterbach (1957) found greater IQ score improvement in adult patients treated with placebo than in those treated with chlorpromazine.…”

mentioning

confidence: 99%

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Effects of chlorpromazine on learning and related processes in emotionally disturbed children.

Mm¹,

Rc²,

Sl³

1963

Journal of Consulting Psychology

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39 children in a psychiatric hospital were tested on 2 types of learning tasks and several performance tasks before, during, and after a 4-week period on chlorpromazine or placebo, the types of medication being assigned randomly in a double-blind design. Medication was controlled according to clinical criteria. Paired-associate learning was less efficient under chlorpromazine, especially on later learning trials and among initially slower learning Ss. Serial learning and tapping rate showed less consistent trends. Porteus Maze Mental Age scores declined under chlorpromazine, while Q scores on the same test tended to improve. No drug effect was noted on remote or immediate memory. The results were tentatively interpreted in terms of impairment of attention span by chlorpromazine.

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Section: Discussionsupporting

confidence: 85%

mentioning

confidence: 99%

Effects of chlorpromazine on learning and related processes in emotionally disturbed children.

Mm¹,

Rc²,

Sl³

1963

Journal of Consulting Psychology

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“…Twenty schizophrenic patients, 10 receiving neuroleptic and 10 receiving both neuroleptic and anticholinergic medication (7 males and 3 female in each group), participated in the study. Neuroleptic medication is usually found not to affect such memory tasks appreciably (Datson, 1959;Koh & Kay ton, 1974;Calev et al 1983;Pearl, 1962;Vestre, 1961;Mason-Brown & Bothwick, 1957;Helper et al 1963;Gardiner et al 1955), while anticholinergic medication is sometimes reported to affect them (e.g. Potamianos & Kellett, 1982;Tune et al 1982).…”

Section: Subjectsmentioning

confidence: 99%

Recall and recognition in mildly disturbed schizophrenics: the use of matched tasks

Calev¹

1984

Psychol. Med.

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SynopsisUnlike previous studies, this study shows that in controlled conditions non-chronic schizophrenics receiving neuroleptic medication show no disparity between recall and recognition. Patients receiving both neuroleptic and anticholinergic drugs show this disparity, performing less well on recall than on recognition. These patients also seem more severely disturbed. The importance of task matching, drugs and chronicity are discussed.

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“…Seventeen of the subjects were receiving maintenance phenothiazines; the eighteenth subject was not on medication at the time of the experiment. Many studies have shown that phenothiazines do not have an adverse effect on memory or verbal performance (Gardiner et al 1955;Daston 1959;Mason-Brown and Borthwick 1957;Vestre 1961;Kelly et al 1958aKelly et al , 1958b.…”

Section: Methodsmentioning

confidence: 99%

The Effect of a Dual Level Word List on Schizophrenic Free Recall

Lutz

Marsh

1981

Schizophrenia Bulletin

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Three-category dual level, three-category single level, and six-category single level word lists were presented for single trial free recall to 18 normals and 18 schizophrenics in remission. Schizophrenic recall was significantly inferior to that of normals across all three lists. Normals produced more clustering than schizophrenics, but the difference was not significant. Across both groups, the three-category dual level list produced significantly more recall than the other two lists. The three-category dual level list and the three-category single level list produced significantly more clustering than the six-category single level list. The results were interpreted as indicating that the schizophrenic's memory structure is similar to that of normals. It is suggested that the schizophrenic's recall deficit is not due to a lack of structure, or an inappropriate structure, but rather to a lessened tendency to utilize such structure.

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The effects of thorazine on learning and retention in schizophrenic patients.

Cited by 27 publications

References 14 publications

Effects of chlorpromazine on learning and related processes in emotionally disturbed children.

Effects of chlorpromazine on learning and related processes in emotionally disturbed children.

Recall and recognition in mildly disturbed schizophrenics: the use of matched tasks

The Effect of a Dual Level Word List on Schizophrenic Free Recall

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