The effects of the Chinese medicine ZiBu PiYin recipe on the hippocampus in a rat model of diabetes-associated cognitive decline: a proteomic analysis

Shi, Xiang; Lu, Xiaoguang; Zhan, Lijun; Qi, Xin; Liang, Lina; Hu, Shiwei; Yu, Yan; Zhao, Shui-Ping; Sui, Hua; Zhang, F. L.

doi:10.1007/s00125-011-2147-z

Cited by 66 publications

(58 citation statements)

References 48 publications

(54 reference statements)

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“…The fat-fed/STZ rat model was developed as previously described with modifications [23,24] . Sixty SPF male SD rats were acclimated for 2 weeks (weeks 0-2), then randomly divided into two groups: normal control (NC, n=10), and highfat diet (HFD, n=50).…”

Section: Induction Of Fat-fed/stz Rat Modelmentioning

confidence: 99%

Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways

et al. 2016

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Aim:We have shown that rutaecarpine extracted from the dried fruit of Chinese herb Evodia rutaecarpa (Juss) Benth (Wu Zhu Yu) promotes glucose consumption and anti-inflammatory cytokine expression in insulin-resistant primary skeletal muscle cells. In this study we investigated whether rutaecarpine ameliorated the obesity profiles, lipid abnormality, glucose metabolism and insulin resistance in rat model of hyperlipidemia and hyperglycemia. Methods: Rats fed on a high-fat diet for 8 weeks, followed by injection of streptozotocin (30 mg/kg, ip) to induce hyperlipidemia and hyperglycemia. One week after streptozotocin injection, the fat-fed, streptozotocin-treated rats were orally treated with rutaecarpine (25 mg·kg -1 ·d -1 ) or a positive control drug metformin (250 mg·kg -1 ·d -1 ) for 7 weeks. The body weight, visceral fat, blood lipid profiles and glucose levels, insulin sensitivity were measured. Serum levels of inflammatory cytokines were analyzed. IRS-1 and Akt/PKB phosphorylation, PI3K and NF-κB protein levels in liver tissues were assessed; pathological changes of livers and pancreases were examined. Glucose uptake and AMPK/ACC2 phosphorylation were studied in cultured rat skeletal muscle cells in vitro. Results: Administration of rutaecarpine or metformin significantly decreased obesity, visceral fat accumulation, water consumption, and serum TC, TG and LDL-cholesterol levels in fat-fed, streptozotocin-treated rats. The two drugs also attenuated hyperglycemia and enhanced insulin sensitivity. Moreover, the two drugs significantly decreased NF-κB protein levels in liver tissues and plasma TNF-α, IL-6, CRP and MCP-1 levels, and ameliorated the pathological changes in livers and pancreases. In addition, the two drugs increased PI3K p85 subunit levels and Akt/PKB phosphorylation, but decreased IRS-1 phosphorylation in liver tissues. Treatment of cultured skeletal muscle cells with rutaecarpine (20-180 μmol/L) or metformin (20 μmol/L) promoted the phosphorylation of AMPK and ACC2, and increased glucose uptake. Conclusion: Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating IRS-1/ PI3K/Akt signaling pathway in liver and AMPK/ACC2 signaling pathway in skeletal muscles.

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Section: Induction Of Fat-fed/stz Rat Modelmentioning

confidence: 99%

Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways

et al. 2016

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“…A formulation that contains more than two Chinese herbs conforms more closely to TCM theories and better reflects the characteristics of TCM than the administration of a single herb (Jiao et al, 2004). Studies of the effects of CHM formulas are attracting increasing attention globally (Shi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the acute and subchronic toxicity of Ziwan Baibu Tang

Xin¹,

Peng²,

Luo³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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“…The majority of TCMs have not resulted in any serious side-effects. Furthermore, since the mechanism of action involves multiple components, pathways and targets, TCMs may have significant advantages compared with single-component drugs for the treatment of multifactor, complex chronic diseases, including AD (5). Specific TCM formulations have been shown to be effective against numerous cognitive disorders.…”

Section: Introductionmentioning

confidence: 99%

Effects of Fructus Akebiae on learning and memory impairment in a scopolamine-induced animal model of dementia

Wang

et al. 2014

Experimental and Therapeutic Medicine

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Fructus Akebiae (FAE) is a component of traditional Chinese medicines used for the clinical treatment of amnesia. The aim of the present study was to investigate the effects of FAE extract on scopolamine-induced learning and memory impairment in mice and Sprague-Dawley rats. Treatment with FAE (2.5, 5 and 10 mg/kg) was investigated in scopolamine-treated animals, and its effects on different types of memory were examined using the T-maze, the Morris water maze task, the novel object recognition test, the passive avoidance task and the step-down test. The results revealed that 5 and 10 mg/kg FAE attenuated scopolamine-mediated impairment of cognition, including spatial, episodic, aversive, and short- and long-term memory. Overall, these results suggest that FAE is an effective cognitive enhancer, and thus highlights the value of a multi-target strategy to address the complexity of cognitive dysfunction in Alzheimer’s disease.

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The effects of the Chinese medicine ZiBu PiYin recipe on the hippocampus in a rat model of diabetes-associated cognitive decline: a proteomic analysis

Cited by 66 publications

References 48 publications

Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways

Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways

Evaluation of the acute and subchronic toxicity of Ziwan Baibu Tang

Effects of Fructus Akebiae on learning and memory impairment in a scopolamine-induced animal model of dementia

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