Evaluation of the acute and subchronic toxicity of Ziwan Baibu Tang

Xin, Ruihua; Peng, Wenjing; Luo, Yang; Wang, Gui-bo; Luo, Cheng; Jiasheng, Xie; Li, Jinyu; Ge, Liang; Zheng, Jufeng

doi:10.4314/ajtcam.v13i3.17

Cited by 1 publication

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“…Therefore, the MHTA-induces spleen damage mechanism may be similar to that of pyrrolizidine alkaloid. Meanwhile, the activity of adrenocortical hormone may initiate negative feedback regulation, thereby inhibit the productions of red blood cells and hemoglobin [38]. Moreover, a significant increase of PCT in 1000 mg/kg group (both male and female) may be caused by the increase of PLT, which is consistent with the reported results [39].…”

Section: Aggregationssupporting

confidence: 90%

Acute and Sub-Acute Toxicological Evaluations of Bioactive Alkaloidal Extract from Melodinus henryi and Their Main Chemical Constituents

Yang

Wang

Fan

et al. 2020

Nat. Prod. Bioprospect.

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Melodinus henryi is a good source of terpenoid indole alkaloids, and traditionally used as a folk medicine in the treatment of meningitis and fracture. In order to further exploit their potential uses, its anti-inflammatory and immunosuppressive activities, safety evaluations and chemical profiles have been illustrated. Compared to the crude methanol extract from M. henryi and its non-alkaloidal fraction, the total alkaloidal fraction (MHTA) had the strongest anti-inflammatory and immunosuppressive activities. In the acute oral toxicity assay, the half lethal dose (LD 50) of MHTA was more than 2000 mg/kg. The sub-acute toxicity assay for consecutive 28 days exhibited MHTA at a lower concentrations of less than 500 mg/kg might be regarded as safe, and might damage spleen, liver, kidney, and heart when the dose is higher than 1000 mg/kg. In addition, a phytochemical investigation on MHTA led to the isolation of 15 monoterpenoid indole alkaloids. Thus, in regard with the potent side effects of MHTA, it should be used with caution in the development of phytomedicine. Meilian Yang and Yudan Wang have contributed equally to this work.

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Section: Aggregationssupporting

confidence: 90%