The Effects of Starvation and Refeeding on Oxidative Stress Parameters (MDA, SOD, GPx), Lipid Profile, Thyroid Hormones and Thyroid Histopathology in Male Wistar Rats

Omidi, Arash; Namazi, Fatemeh; Jabire, Saeed; Afsar, Mina; Honarmand, Masumeh; Nazifi, Saeed

doi:10.3823/2109

Cited by 4 publications

(5 citation statements)

References 29 publications

(34 reference statements)

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“…Vitamin C or E treatment alone was reported to be effective in reducing the negative effects of stress [22][23][24]. Vitamin C functions to maintain the fat-soluble Vitamin E. In particular, Vitamin C also plays a role in activating Vitamin E when it loses its antioxidant capacity by turning into tocopherol.…”

Section: Discussionmentioning

confidence: 99%

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Amelioration on oxidative stress, testosterone, and cortisol levels after administration of Vitamins C and E in albino rats with chronic variable stress

et al. 2021

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Background and Aim: Stress can cause physiological and biological disorders in the body. On the other hand, antioxidants from vitamins and minerals are effective for stress treatment. Therefore, this study aimed to evaluate the effect of the administration of Vitamins C and E on serum superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GPx), testosterone, and cortisol activity in albino rats with chronic variable stress (CVS). Materials and Methods: Twenty albino rats were randomly assigned into four treatment groups: C was administered normal saline; T1 was administered Vitamins C and E; T2 was only induced CVS; and T3 was induced CVS followed by Vitamins C and E administration. All treatments were applied for 4 weeks, respectively. Furthermore, 5 mL of blood samples were collected intracardially. Body weight data were collected for the initial and final weights. From serum samples, SOD, GPx, and CAT were measured using the enzymol method; MDA was measured using the high-performance liquid chromatography method; and testosterone and cortisol were measured using the enzyme-linked immunosorbent assay method. All variables were analyzed statistically using analysis of variance followed by the Duncan test (p<0.05). Results: Our findings showed that the T1 and T3 groups significantly decreased (p<0.001) compared to T2 in the following parameters: SOD, MDA, GPx, and cortisol. Meanwhile, CAT and testosterone levels in the T1 and T3 groups were significantly increased (p<0.001) compared to the T2 group. In addition, the weight gain in T1 and T3 groups was significantly increased (p<0.001) compared to T2 group. Conclusion: It can be concluded that the administration of Vitamins C and E had a significant effect to alleviate SOD, MDA, GPx, and cortisol and to improve the testosterone level in albino rats with CVS.

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Section: Discussionmentioning

confidence: 99%

“…Serum testosterone and cortisol were estimated using the enzyme-linked immunosorbent assay method (My-Bio-Source ® , San Diego, CA, USA) [20]. The remaining serum was used to measure serum SOD, MDA, CAT, and GPx levels [21,22].…”

Section: Serum Evaluationmentioning

confidence: 99%

Amelioration on oxidative stress, testosterone, and cortisol levels after administration of Vitamins C and E in albino rats with chronic variable stress

et al. 2021

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“…Refeeding, critical to the sustained recovery of patients with anorexia nervosa, is another potential contributor to the upregulated immune system presumed in this condition. Although unstudied in eating disorders, oxidative stress is increased in animal models of starvation when undergoing refeeding and may potentially be related to increased adiposity (and associated adipokine secretion) with weight gain [126]. Increased central adiposity has indeed been found in anorexia nervosa with weight restoration [127], and this regional adiposity is very metabolically active [128].…”

Section: Oxidative Stressmentioning

confidence: 99%

Anorexia Nervosa and the Immune System—A Narrative Review

Gibson

Mehler

2019

JCM

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The pathogenesis of an increasing number of chronic diseases is being attributed to effects of the immune system. However, its role in the development and maintenance of anorexia nervosa is seemingly under-appreciated. Yet, in examining the available research on the immune system and genetic studies in anorexia nervosa, one becomes increasingly suspicious of the immune system’s potential role in the pathophysiology of anorexia nervosa. Specifically, research is suggestive of increased levels of various pro-inflammatory cytokines as well as the spontaneous production of tumor necrosis factor in anorexia nervosa; genetic studies further support a dysregulated immune system in this disorder. Potential contributors to this dysregulated immune system are discussed including increased oxidative stress, chronic physiological/psychological stress, changes in the intestinal microbiota, and an abnormal bone marrow microenvironment, all of which are present in anorexia nervosa.

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“…In our work, the ROS burst caused by Ang II was alleviated by HSYA. The intracellular ROS accumulation will lead to the disruption of redox system, for example, the activity of MDA and SOD ( 33 , 34 ). In this study, the content of MDA and the activity of SOD were dysregualted by Ang II, however, the treatment of HSYA recovered their balance.…”

Section: Discussionmentioning

confidence: 99%

Hydroxysafflor yellow A protects against angiotensin II‑induced hypertrophy

Zhou

Jing

et al. 2018

Mol Med Report

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Myocardial infarction (MI) is life-threatening and is generally accompanied by myocardial hypertrophy. Notably, Hydroxysafflor yellow A (HSYA) can prevent tissue injuries. The objective of this study was to investigate the effect of HSYA on hypertrophy after MI. Hematoxylin and eosin (H&E) staining assays were performed to measure cell area. The protein synthesis rate was assessed using the 3H Leucine incorporation assay. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR), western blot analysis and the immunohistochemical assay were used to detect the expression of target genes. The activity of superoxide dismutase (SOD), malondialdehyde (MDA) and the reactive oxygen species (ROS) generation were examined using commercial kits. Decreased myocardial hypertrophy was observed in animals treated with HSYA. Furthermore, the expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) was higher in HSYA administration groups compared with that in the MI model group. In H9c2 cardiomyocytes, the pretreatment with HSYA increased the cell viability, however, it reduced protein synthesis rate, mitigated cell surface area and decreased the expression of Brain natriuretic factor (BNP) and β-myosin heavy chain (β-MHC). By contrast, the downregulation of Nrf2 deteriorated and reversed the effect of Ang II and HSYA. Furthermore, oxidative stress was alleviated by HSYA via inhibiting ROS generation, modulating the activities of SOD and MDA. In addition, the expression of NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1) were recovered by the pretreatment of HSYA that was combated by siNrf2. In conclusion, HSYA exerted anti-hypertrophic effects, which was pertinent with the activation of Nrf2/NQO-1/HO-1 signaling pathway. The findings of this study may inspire a novel strategy to combat MI.

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The Effects of Starvation and Refeeding on Oxidative Stress Parameters (MDA, SOD, GPx), Lipid Profile, Thyroid Hormones and Thyroid Histopathology in Male Wistar Rats

Cited by 4 publications

References 29 publications

Amelioration on oxidative stress, testosterone, and cortisol levels after administration of Vitamins C and E in albino rats with chronic variable stress

Amelioration on oxidative stress, testosterone, and cortisol levels after administration of Vitamins C and E in albino rats with chronic variable stress

Anorexia Nervosa and the Immune System—A Narrative Review

Hydroxysafflor yellow A protects against angiotensin II‑induced hypertrophy

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