The effects of smoking on corneal endothelial cells: a cross-sectional study on a population from Isfahan, Iran

Golabchi, Khodayar; Abtahi, Mohammad‐Ali; Salehi, Ali; Jahanbani-Ardakani, Hamidreza; Ghaffari, Sara; Farajzadegan, Ziba

doi:10.1080/15569527.2017.1317783

Cited by 17 publications

(26 citation statements)

References 30 publications

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“…This leads to tachycardia and increased peripheral resistance. It also stimulates adrenal gland causing more cardiovascular effects [13]. Carbone monoxide (CO) is as high as 100folds higher in smokers comparing with nonsmokers; leading to increment of carbo-…”

Section: Resultsmentioning

confidence: 99%

“…xyhemoglobin and increases tissue hypoxia [13,14]. The corneal endothelial layer plays an indispensable role in keeping the corneal transparency and preservation of vision [15].…”

Section: Resultsmentioning

confidence: 99%

“…The cell density (CD) starts to be around 4000 cell/mm 2 in early childhood, and then declines gradually with age, reaching to only around 2400-2600 cell/mm 2 over the age of 75 years in normal population [13,20]. The normal endothelial cells have hexagonal and regular shapes [21].…”

Section: Resultsmentioning

confidence: 99%

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The Effect of Cigarette Smoking on Corneal Endothelial Cells

Mohamed

Kamel

2019

Egyptian Journal of Clinical Ophthalmology

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Purpose: To reveal the effect of cigarette smoking on corneal endothelial cells. Patients and methods: this is a case control cross sectional study including 99 persons, 61 chronic cigarette smokers and another age matched 38 control nonsmokers. Parameters used in our study were cell density (CD), polymegethism, pleomorphism, the average of cell size, and central corneal thickness (CCT). Results: The mean values of the CD were 2829.9±334.9 compared to 3243.6±237.9, CV were 44.13±9.73 compared to 32.84±2.97, HEX were 40.44±6.95% compared to 60.11±5.83% for smokers and non-smoker groups respectively, with a highly statistically significant value (p <0.001) and on the other hand values were statistically non-significant regarding CCT. There were non-significant relation between the type of smoking (cigarette, shisha or combined). Conclusion:Cigarette smoking has deteriorating effects on some, but not all, of the corneal endothelial measures, with no relation found between this deteriorating effect and both of the dose or type of smoking.

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Section: Resultsmentioning

confidence: 99%

“…xyhemoglobin and increases tissue hypoxia [13,14]. The corneal endothelial layer plays an indispensable role in keeping the corneal transparency and preservation of vision [15].…”

Section: Resultsmentioning

confidence: 99%

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The Effect of Cigarette Smoking on Corneal Endothelial Cells

Mohamed

Kamel

2019

Egyptian Journal of Clinical Ophthalmology

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“…Among our patients, smoking was significantly more common, defined as pack/years, in the moderate-severe COPD group. Golabchi et al reported that smoking results in an increased CV and decreased ECD (15). Ilhan et al (16) reported that smoking does not affect the CCT, CV, and percentage of hexagonality values, but there was a significant reduction in ECD in smokers.…”

Section: Discussionmentioning

confidence: 99%

Assessment of anterior segment parameters and specular microscopy findings in patients with COPD

Taşlı¹

2020

Erciyes Med J

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Objective:The aim of the present study was to assess the anterior segment parameters of patients with chronic obstructive pulmonary disease (COPD) by corneal specular microscopy and biometry and to compare the results with healthy controls. Materials and Methods:Our prospective study consisted of 122 eyes of 61 patients with COPD and 110 eyes of 55 patients without any systemic diseases. A comprehensive medical history was obtained, and corrected visual acuity, bio microscopic and fundus examination, intraocular pressure (IOP) measurement with applanation tonometry, and non-contact specular microscopy were performed in all participants. Results:The endothelial cell density was lower in the COPD group than in the control group (p<0.001). The coefficient of variation (CV) was higher, central corneal thickness was significantly higher, and hexagonal cell ratio (HEX) was lesser in the COPD group than in the control group (p<0.001). Any significant difference between the control and the COPD groups was not determined in comparison with IOP, mean axial length keratometry (Kmean), anterior chamber depth (ACD), and white-to-white limbus length (WTW) measurements. Patients were grouped into two regarding the disease severity as mildmoderate (group 1, n=20), and moderate-severe (group 2, n=41) according to the Global Initiative for Chronic Obstructive Lung Disease criteria. The number of endothelial cells was lesser, the CV was higher, and the HEX was lower in the moderate-severe COPD group than in the mild-moderate COPD group (p<0.001). The duration of smoking was significantly longer in the moderate-severe group than in the mild-moderate COPD group (p<0.001). Conclusion:We suggest that in patients with COPD, due to the reduction of endothelial functional preserve, the risk of corneal endothelial damage is increased in intraocular surgery. In patients with end-stage COPD, caution should be exercised with regard to endothelial decompensation, frequent disease in the general population, corneal parameters, and to define the alterations that the ocular surgeons should be cautious about. Data regarding the alterations in anterior segment parameters in patients with COPD are highly limited in the previous literature.

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“…8,9 Kara and colleagues 10 reported that CS affects the tear break-up time, but no significant differences in the mean central corneal thickness (CCT), mean CEC density, or parameters of endothelial cell morphology were observed between smokers and non-smokers. 10 In another study, Golabchi and colleagues 11 documented that smokers with severe nicotine dependency had substantially greater average cell size and lower CEC density as compared to nonsmokers.…”

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confidence: 98%

Cigarette Smoke Triggers Loss of Corneal Endothelial Cells and Disruption of Descemet's Membrane Proteins in Mice

Ali

Khan

Jang

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To investigate changes at a molecular level in the mouse corneal endothelium (CE) exposed to chronic cigarette smoke (CS). METHODS.Pregnant mice (gestation days 18-20) were placed in a whole-body exposure smoking chamber, and a few days later pups were born. After 3.5 months of CS exposure, a ConfoScan4 scanning microscope was used to examine the corneal endothelial cells (CECs) of CS-exposed and control (Ct) mice. The CE was peeled under a microscope and maintained as four biological replicates (two male and two female) for CS-exposed and Ct mice; each replicate consisted of 16 CEs. The proteome of the CE was investigated through mass spectrometry. RESULTS.The CE images of CS-exposed and Ct mice revealed a difference in the shape of CECs accompanied by a nearly 10% decrease in CEC density (P < 0.00003) following CS exposure. Proteome profiling identified a total of 524 proteins exhibiting statistically significant changes in CE from CS-exposed mice. Importantly, proteins associated with Descemet's membrane (DM), including COL4α1, COL4α2, COL4α3, COL4α4, COL4α5, COL4α6, COL8α1, COL8α2, and FN1, among others, exhibited diminished protein levels in the CE of CS-exposed mice. CONCLUSIONS.Our data confirm that exposure to CS results in reduced CEC density accompanied by diminished levels of multiple collagen and extracellular matrix proteins associated with DM.

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The effects of smoking on corneal endothelial cells: a cross-sectional study on a population from Isfahan, Iran

Abstract: Our study showed that smoking can cause significant changes in some of the corneal endothelial variables, but not all of them.

Cited by 17 publications

References 30 publications

The Effect of Cigarette Smoking on Corneal Endothelial Cells

The Effect of Cigarette Smoking on Corneal Endothelial Cells

Assessment of anterior segment parameters and specular microscopy findings in patients with COPD

Cigarette Smoke Triggers Loss of Corneal Endothelial Cells and Disruption of Descemet's Membrane Proteins in Mice

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