The effects of silver nanoparticles (Ag-NPs) sublethal concentrations on common carp (Cyprinus carpio): Bioaccumulation, hematology, serum biochemistry and immunology, antioxidant enzymes, and skin mucosal responses

Vali, Sara; Mohammadi, Ghasem; Tavabe, Kamran Rezaei; Moghadas, Fatemeh; Naserabad, Saeid Shahbazi

doi:10.1016/j.ecoenv.2020.110353

Cited by 63 publications

(35 citation statements)

References 100 publications

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“…The study of white blood cell (WBC) pro le can provide useful information regarding the general health status of sh. The white blood cells and differential leukocytes number are useful tools to evaluate the immune response in sh (De Pedro et al 2005;Vali et al 2020). In this study, OTC administration signi cantly decreased the WBC and neutrophils values with no signi cant effect on monocytes and lymphocytes.…”

Section: Discussionmentioning

confidence: 57%

The ameliorative role of ascorbic acid against blood disorder, immunosuppression, and oxidative damage of oxytetracycline in rainbow trout (Oncorhynchus mykiss)

Moradi

Javanmardi

Gholamzadeh

et al. 2022

Fish Physiol Biochem

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This experiment aimed to determine the possible bene cial effects of dietary ascorbic acid (AA) on hematological indices, immune responses, and antioxidative capacity of Oncorhynchus mykiss treated with antibiotic oxytetracycline (OTC). 150 sh were divided evenly among ve experimental groups (30 sh of each, in 3 replicates) receiving diets containing OTC (0 and 100 mg per kg sh weight) and AA (100, 200, 400 and 800 mg per kg sh diet) for 28 days. Treatments include group A or control (100 mg AA without OTC), group B (100 mg AA with OTC), group C (200 mg AA with OTC), group D (400 mg AA with OTC), and group E (800 mg AA with OTC). The results obtained showed that the hematological indices (red blood cells, white blood cells, hematocrit, hemoglobin and neutrophils), immunological parameters (plasma lysozyme, plasma complement and skin mucus alkaline phosphatase activities), and antioxidant enzymes activities (superoxide dismutase and catalase) were signi cantly decreased by OTC in O. mykiss fed control diet (P < 0.05). The results also revealed that OTC signi cantly increased the activity of biochemical enzymes (aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase) in the plasma of O. mykiss fed control diet (P < 0.05). However, in comparison to the control diet, feeding sh with higher amounts of AA (400 and 800 mg/kg diet) signi cantly restored the hematological, immunological, and antioxidative responses in OTC treated groups (p < 0.05). These ndings show that the dietary supplementation of AA at 400 or 800 mg/kg diet is bene cial in relieving O. mykiss from OTC-induced oxidative stress and immunosuppression.

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Section: Discussionmentioning

confidence: 57%

The ameliorative role of ascorbic acid against blood disorder, immunosuppression, and oxidative damage of oxytetracycline in rainbow trout (Oncorhynchus mykiss)

Moradi

Javanmardi

Gholamzadeh

et al. 2022

Fish Physiol Biochem

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“…Once liver cells are damaged, AST and ALT are released from liver cells into the blood (Palanivelu et al, 2005). The elevated serum AST activities are indicative of mitochondrial disruption (Schmidt & Schmidt, 1974; Vali et al, 2020) and release of ALT into the blood is the result of loss of integrity of hepatocyte membranes (Mitchell et al, 1980). Therefore, the increased levels of these two enzymes in the serum of fluoride‐exposed fish were probably indicative of the hepatotoxic effects of the fluoride.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effects of dietary Vitamin‐C on growth performance and hemato‐biochemical response of sodium fluoride‐intoxicated Amur Carp, Cyprinus carpio haematopterus

Kaur

Batra

Shah

et al. 2022

Aquaculture Research

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This study aimed to assess the ameliorative dietary effect of vitamin‐C against sodium fluoride (NaF)‐induced toxicity on growth and haemato‐biochemical parameters in Amur carp. A total of 150 fish (average body weight 169 ± 0.69 g) were randomly distributed into five groups (with three triplicates) including G1 (control); G2 (NaF exposure @100 ppm); G3 (vitamin‐C supplemented diet @100 ppm); G4 (both NaF exposure @100 ppm and vitamin‐C supplemented diet @100 ppm) and G5 (NaF exposure @100 ppm for 60 days and then vitamin‐C supplemented diet @200 ppm for last 30 days). Results revealed that growth and hemato‐biochemical profile was best in G3 in comparison with G1, whereas groups G2, G4 and G5 have shown retarded growth, a decrease in Hb, TEC, PCV, MCV, MCH and MCHC. Serum‐biochemical parameters were found optimum in G3 as compared with G1 and in groups of G2, G4 and G5, total serum protein, albumin, globulin, glucose, and triglyceride levels decreased significantly, whereas creatinine, AST and ALT levels increased significantly. In G4, toxicity was less severe in comparison with G2, whereas in G5, after the dietary supplementary of vitamin‐C, parameters have shown a bend towards the normal values. Thus, it can be concluded that vitamin‐C has ameliorative action against fluoride toxicity in fish.

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“…In vertebrates, like rainbow trout, ions released as a result of NPs dissolution are internalized in the cell through transporter proteins or ion channels (Abbas et al 2020). In common carp, even exposure to sublethal concentrations of AgNPs LC50 (96 h) for 21 days can induce some toxicity (Vali et al 2020).…”

Section: Discussionmentioning

confidence: 99%

Nanosilver toxicity thresholds estimative for aquatic and sediment environmental safety

Vl¹,

Jonsson²,

Msgm³

et al. 2021

Preprint

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Silver nanoparticles (AgNPs) have been largely utilized. Despite that, comprehensive studies on their ecotoxicological effects and environmental risk are still required. In the present study, the AgNPs effect was assessed to some organisms including algae, plants, microcrustaceans, cnidaria, nematodes, aquatic insect, earthworm, and fish embryos. The no-observed-effect concentration (NOEC) was calculated for each organism using a log-logistic function. AgNPs remained stable in contact with culture media during the analyzed period and conditions employed, presenting dispersion less than 20%, except for Artemia salina medium. On this occasion, NPs presented dispersion of approximately 25%, although their size remained unchangeable. The Predicted No Effect Concentration (PNEC) of AgNPs in the aquatic compartment was estimated in the concentration range from 0.13 to 0.66 µg L-1. A Risk Quotient (RQ) of 15.1 was derived for the NP tested with the aid of a maximum AgNPs Predicted Environmental Concentration (PEC) estimated value. The RQ value superior to one indicates a risk and the need for its management measures implementation. These data, in addition to the expected increase in AgNPs use, reinforce the importance of the AgNPs safety levels establishment that can contribute to performing their risk assessment studies.

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The effects of silver nanoparticles (Ag-NPs) sublethal concentrations on common carp (Cyprinus carpio): Bioaccumulation, hematology, serum biochemistry and immunology, antioxidant enzymes, and skin mucosal responses

Cited by 63 publications

References 100 publications

The ameliorative role of ascorbic acid against blood disorder, immunosuppression, and oxidative damage of oxytetracycline in rainbow trout (Oncorhynchus mykiss)

The ameliorative role of ascorbic acid against blood disorder, immunosuppression, and oxidative damage of oxytetracycline in rainbow trout (Oncorhynchus mykiss)

Ameliorative effects of dietary Vitamin‐C on growth performance and hemato‐biochemical response of sodium fluoride‐intoxicated Amur Carp, Cyprinus carpio haematopterus

Nanosilver toxicity thresholds estimative for aquatic and sediment environmental safety

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