The Effects of Resveratrol on Telomeres and Post Myocardial Infarction Remodeling

Gutlapalli, Sai Dheeraj; Kondapaneni, Varshitha; Toulassi, Ijeoma A; Poudel, Sujan; Zeb, Mehwish; Choudhari, Jinal; Cancarevic, Ivan

doi:10.7759/cureus.11482

Cited by 5 publications

(7 citation statements)

References 44 publications

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“…Resveratrol plays an important role in antioxidation, anti-inflammatory effect, regulating immune cells and improving vascular function, improving neurohumoral regulation, improving cardiomyocytes’ proliferation, promoting autophagy, inhibiting myocardial fibrosis and its impact on mitochondrial degradation and lipid metabolism, so as to achieve the protective purpose of maintaining the normal function of myocardial cells. Therefore, resveratrol has the advantage of inhibiting cardiac remodeling ( Gutlapalli et al, 2020 ). This review concludes the research of resveratrol in cardiac remodeling, in order to provide support for its research in the prevention and treatment of cardiac remodeling related diseases.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, SIRT3 stimulation can reduce ROS level and AKT1 signal and prevent myocardial hypertrophy, which may be one of the mechanisms of resveratrol inhibiting cardiac remodeling ( Sundaresan et al, 2009 ; Pillai et al, 2010 ; Tannous et al, 2021 ). Moreover, resveratrol can promote telomerase and can resist the development of cardiac remodeling caused by aging and adverse remodeling after myocardial infarction ( Gutlapalli et al, 2020 ).…”

Section: Possible Relevant Mechanismsmentioning

confidence: 99%

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Role of resveratrol in inhibiting pathological cardiac remodeling

Fan

You

et al. 2022

Front. Pharmacol.

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Cardiovascular disease is a group of diseases with high mortality in clinic, including hypertension, coronary heart disease, cardiomyopathy, heart valve disease, heart failure, to name a few. In the development of cardiovascular diseases, pathological cardiac remodeling is the most common cardiac pathological change, which often becomes a domino to accelerate the deterioration of the disease. Therefore, inhibiting pathological cardiac remodeling may delay the occurrence and development of cardiovascular diseases and provide patients with greater long-term benefits. Resveratrol is a non-flavonoid polyphenol compound. It mainly exists in grapes, berries, peanuts and red wine, and has cardiovascular protective effects, such as anti-oxidation, inhibiting inflammatory reaction, antithrombotic, dilating blood vessels, inhibiting apoptosis and delaying atherosclerosis. At present, the research of resveratrol has made rich progress. This review aims to summarize the possible mechanism of resveratrol against pathological cardiac remodeling, in order to provide some help for the in-depth exploration of the mechanism of inhibiting pathological cardiac remodeling and the development and research of drug targets.

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Section: Discussionmentioning

confidence: 99%

Section: Possible Relevant Mechanismsmentioning

confidence: 99%

Role of resveratrol in inhibiting pathological cardiac remodeling

Fan

You

et al. 2022

Front. Pharmacol.

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“…Thus, cardiorespiratory fitness is increased by exercise training, resveratrol intake, and a combined exercise and resveratrol induce physiologic and pathologic transition. As we know, MEK1/2 and ERK1/2 identified left ventricular physiologic hypertrophy, however, NFATc3 and calcineurin are identified as left ventricular pathologic hypertrophy [25]. Some reports show that not find ERK1/2 and NFATc3 were binding together.…”

Section: Resveratrol Supplements In Combination With Cardiorespirator...mentioning

confidence: 98%

Resveratrol Supplements Reduce the Risk of Aging-Related Cardiac Disease after Cardiorespiratory Fitness

Wu¹,

Zhu²,

Li³

et al. 2023

Resveratrol - Recent Advances, Application, and Therapeutic Potential [Working Title]

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Aging changes in the very elderly cardiac disease are associated with physiological and pathological changes, however, all observed changes in aging are associated with a deterioration of cardiorespiratory fitness function. For example, hypertension and cardiorespiratory disease make difficult distinctions between normal aging changes and the effects of underlying resveratrol supplements processes. Cardiorespiratory fitness-independent changes in resveratrol intake are still unclear. This review aimed to discuss whether the aging-associated cardiorespiratory fitness changes in the heart can be reversed by resveratrol supplements, and the mechanisms of cardiorespiratory fitness. Aging led to apoptosis and fibrosis-related protein expression increased, however, cardiorespiratory fitness had revered more functions. Resveratrol supplements in combination with cardiorespiratory fitness had a good enhanced mitochondrial function in aging including IL-6, STAT3, MEK5, and MEK1/ERK1 increased. Resveratrol supplements also induced survival signals and downregulation of apoptosis signaling in aging. Therefore, we suggest resveratrol has enhanced cardiorespiratory fitness to combine their function in repressed aging.

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“…Likewise, some supplements have been used for therapeutic purposes, such as resveratrol, a polyphenolic compound found in grapes, which increases telomerase activity by increasing the expression of the catalytic subunit hTERT in a dose-dependent manner in patients who suffered from myocardial infarction [300] and improved glucose (glycated hemoglobin) and insulin levels in middle-aged subjects with T2DM [301], conferring hypoglycaemic, antioxidant, and anti-inflammatory properties [302]. Similar properties have been attributed to chayote, which maintains telomerase levels associated with an increase in SOD and a decrease in OxS together with a decrease in TNF-α in patients with MetS [189,274].…”

Section: Effect Of Healthy Lifestyles On Oxidative Stress and The Telomere Lengthmentioning

confidence: 99%

Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging

Gavia-García

Rosado-Pérez

Arista-Ugalde

et al. 2021

Biology

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A great amount of scientific evidence supports that Oxidative Stress (OxS) can contribute to telomeric attrition and also plays an important role in the development of certain age-related diseases, among them the metabolic syndrome (MetS), which is characterised by clinical and biochemical alterations such as obesity, dyslipidaemia, arterial hypertension, hyperglycaemia, and insulin resistance, all of which are considered as risk factors for type 2 diabetes mellitus (T2DM) and cardiovascular diseases, which are associated in turn with an increase of OxS. In this sense, we review scientific evidence that supports the association between OxS with telomere length (TL) dynamics and the relationship with MetS components in aging. It was analysed whether each MetS component affects the telomere length separately or if they all affect it together. Likewise, this review provides a summary of the structure and function of telomeres and telomerase, the mechanisms of telomeric DNA repair, how telomere length may influence the fate of cells or be linked to inflammation and the development of age-related diseases, and finally, how the lifestyles can affect telomere length.

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The Effects of Resveratrol on Telomeres and Post Myocardial Infarction Remodeling

Cited by 5 publications

References 44 publications

Role of resveratrol in inhibiting pathological cardiac remodeling

Role of resveratrol in inhibiting pathological cardiac remodeling

Resveratrol Supplements Reduce the Risk of Aging-Related Cardiac Disease after Cardiorespiratory Fitness

Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging

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