Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging

Gavia-García, Graciela; Rosado-Pérez, Juana; Arista-Ugalde, Taide Laurita; Aguíñiga-Sánchez, Itzen; Santiago‐Osorio, Edelmiro; Mendoza-Núñez, Vı́ctor Manuel

doi:10.3390/biology10040253

Cited by 53 publications

(28 citation statements)

References 307 publications

(311 reference statements)

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“…One mechanism through which lipid as well as fatty acid metabolism may influence telomere length is oxidative stress, which is proposed as a cause of aging (68)(69)(70) and is known to attenuate telomere length attrition (71)(72)(73). Fat accumulation has been associated with oxidative stress (74), and previous studies have shown that oxidative stress is involved in the development of age-related diseases, including the metabolic syndrome (74,75). The metabolic syndrome is defined by clinical and biochemical alterations characterized by multiple components such as obesity, dyslipidaemia, arterial hypertension, hyperglycaemia and insulin resistance (75,76).…”

Section: Discussionmentioning

confidence: 99%

“…Fat accumulation has been associated with oxidative stress (74), and previous studies have shown that oxidative stress is involved in the development of age-related diseases, including the metabolic syndrome (74,75). The metabolic syndrome is defined by clinical and biochemical alterations characterized by multiple components such as obesity, dyslipidaemia, arterial hypertension, hyperglycaemia and insulin resistance (75,76). These components have been associated with oxidative damage at DNA and lipid level and also with shorter telomere length (75).…”

Section: Discussionmentioning

confidence: 99%

“…The metabolic syndrome is defined by clinical and biochemical alterations characterized by multiple components such as obesity, dyslipidaemia, arterial hypertension, hyperglycaemia and insulin resistance (75,76). These components have been associated with oxidative damage at DNA and lipid level and also with shorter telomere length (75). Interestingly, statins have been shown to prevent telomere length shortening through decreasing oxidative stress (77).…”

Section: Discussionmentioning

confidence: 99%

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Fat metabolism is associated with telomere length in six population-based studies

Spek

Karamujić‐Čomić

Pool

et al. 2021

Human Molecular Genetics

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Telomeres are repetitive DNA sequences located at the end of chromosomes, which are associated to biological aging, cardiovascular disease, cancer, and mortality. Lipid and fatty acid metabolism have been associated with telomere shortening. We have conducted an in-depth study investigating the association of metabolic biomarkers with telomere length (LTL). We performed an association analysis of 226 metabolic biomarkers with LTL using data from 11 775 individuals from six independent population-based cohorts (BBMRI-NL consortium). Metabolic biomarkers include lipoprotein lipids and subclasses, fatty acids, amino acids, glycolysis measures and ketone bodies. LTL was measured by quantitative polymerase chain reaction or FlowFISH. Linear regression analysis was performed adjusting for age, sex, lipid-lowering medication and cohort-specific covariates (model 1) and additionally for body mass index (BMI) and smoking (model 2), followed by inverse variance-weighted meta-analyses (significance threshold pmeta = 6.5x10−4). We identified four metabolic biomarkers positively associated with LTL, including two cholesterol to lipid ratios in small VLDL (S-VLDL-C % and S-VLDL-ce %) and two omega-6 fatty acid ratios (FAw6/FA and LA/FA). After additionally adjusting for BMI and smoking, these metabolic biomarkers remained associated with LTL with similar effect estimates. In addition, cholesterol esters in very small VLDL (XS-VLDL-ce) became significantly associated with LTL (p = 3.6x10−4). We replicated the association of FAw6/FA with LTL in an independent dataset of 7845 individuals (p = 1.9x10−4). To conclude, we identified multiple metabolic biomarkers involved in lipid and fatty acid metabolism that may be involved in LTL biology. Longitudinal studies are needed to exclude reversed causation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Fat metabolism is associated with telomere length in six population-based studies

Spek

Karamujić‐Čomić

Pool

et al. 2021

Human Molecular Genetics

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“…used data from 193 middle-aged Arabs and found that HOMA-IR was inversely associated with LTL in men ( 33 ). A recent observation study included 305 participants with type 2 diabetes demonstrated that both telomere length and telomerase activity progressively decreased as IR increased ( 34 ). GEMINAKAR study conducted in 338 (184 monozygotic and 154 dizygotic) same-sex twin pairs and failed to find a significant IR-LTL association ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Triglyceride-Glucose Index Correlate With Telomere Length in Healthy Adults From the National Health and Nutrition Examination Survey

Zhang

Bai

et al. 2022

Front. Endocrinol.

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AimThe present investigation was designed to test the association between leukocyte telomere length (LTL) and two simple markers of insulin resistance, that is, homeostatic model assessment of insulin resistance (HOMA-IR) and triglyceride-glucose (TyG) index in U.S. adults without metabolic diseases.MethodsA total of 6489 U.S. adults without diabetes from NHANES 1999–2002 were analyzed. TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. HOMA-Index was calculated as fasting plasma glucose (mmol/L) × fasting serum insulin (mU/mL)/22.5. LTL was obtained using the quantitative polymerase chain reaction method. Multivariate linear regression analysis was assessed to evaluate the association of TyG index HOMA-IR with LTL. We further conducted a generalized additive model (GAM) and a fitted smoothing curve with penalized spline method.ResultsIt was found that the mean LTL was 5796.1 bp in the measured healthy adults. Overall, TyG index was significantly associated with LTL, while HOMA-IR was not. Compared with participants in tertile 1 of the TyG index, the β (95% CI) for those in the second (8.27 to 8.77) and third (≥ 8.77) were -4.31 (95% CI: -48.12~39.49) and -95.98 (95% CI: -145.08~-46.89), respectively. Subjects with TyG index ≥ 8.77 had statistically significant shorter LTL (β = -93.33, 95%CI: -134.33~-52.32), compared with TyG index < 8.77. We further explored a dose-response relation between TyG index by a decile approach [≤ 7.81 (reference), 7.81-8.04, 8.04-8.21, 8.21-8.37, 8.37-8.52, 8.52-8.68, 8.68-8.83, 8.83-9.03, 9.03-9.33, and >9.33] and LTL. Five subgroups (TyG index 7.81-8.04, 8.04-8.21, 8.21-8.37, 8.37-8.52, and 8.52-8.68) did not show significant effect on LTL; while there was a significantly shorter LTL for participants with the TyG index > 8.68, supporting a threshold effect of TyG index on LTL.ConclusionsThe results suggested that higher TyG index (> 8.68) was closely related to shorter LTL and the TyG index was better associated with LTL than HOMA-IR.

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“…A number of epidemiological and population studies provided evidence that leukocyte telomere shortening is associated with aging [ 18 , 19 , 20 , 25 ] and with age-related chronic diseases, although some inconsistencies have been observed [ 26 , 27 , 28 , 29 ]. LTL was also investigated in the neurodegenerative diseases Alzheimer’s (AD), Parkinson’s (PD), and Huntington’s (HD) diseases and Friedreich’s ataxia (FRDA).…”

Section: Introductionmentioning

confidence: 99%

Leukocyte Telomere Length Variability as a Potential Biomarker in Patients with PolyQ Diseases

et al. 2022

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SCA1, SCA2, and SCA3 are the most common forms of SCAs among the polyglutamine disorders, which include Huntington’s Disease (HD). We investigated the relationship between leukocyte telomere length (LTL) and the phenotype of SCA1, SCA2, and SCA3, comparing them with HD. The results showed that LTL was significantly reduced in SCA1 and SCA3 patients, while LTL was significantly longer in SCA2 patients. A significant negative relationship between LTL and age was observed in SCA1 but not in SCA2 subjects. LTL of SCA3 patients depend on both patient’s age and disease duration. The number of CAG repeats did not affect LTL in the three SCAs. Since LTL is considered an indirect marker of an inflammatory response and oxidative damage, our data suggest that in SCA1 inflammation is present already at an early stage of disease similar to in HD, while in SCA3 inflammation and impaired antioxidative processes are associated with disease progression. Interestingly, in SCA2, contrary to SCA1 and SCA3, the length of leukocyte telomeres does not reduce with age. We have observed that SCAs and HD show a differing behavior in LTL for each subtype, which could constitute relevant biomarkers if confirmed in larger cohorts and longitudinal studies.

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Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging

Cited by 53 publications

References 307 publications

Fat metabolism is associated with telomere length in six population-based studies

Fat metabolism is associated with telomere length in six population-based studies

Triglyceride-Glucose Index Correlate With Telomere Length in Healthy Adults From the National Health and Nutrition Examination Survey

Leukocyte Telomere Length Variability as a Potential Biomarker in Patients with PolyQ Diseases

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