Triglyceride-Glucose Index Correlate With Telomere Length in Healthy Adults From the National Health and Nutrition Examination Survey

Hu, Lihua; Zhang, Qiaojian; Bai, Yi; Hu, Guiping; Li, Jianping

doi:10.3389/fendo.2022.844073

Cited by 5 publications

(4 citation statements)

References 44 publications

(50 reference statements)

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“…Consistently, the tertile 3 of the TyG index, a biomarker of insulin resistance, was 8.77, and a high TyG index (>8.77), not HOMA-IR, was negatively and independently associated with leukocyte telomere length among non-diabetic U.S. adults from NHANES. 52 In an atherosclerosis cohort survey performed in the Shijingshan District in Beijing, the mean TyG index was 8.81. 53 In a cohort study in Sweden, the means TyG index of individuals with isolated impaired fasting glucose, with combined glucose intolerance, and with diabetes-treatment-naive T2D were 8.6 ± 0.04, 8.8 ± 0.06, and 9.2 ± 0.1, respectively.…”

Section: Discussionmentioning

confidence: 99%

MTBE exposure may increase the risk of insulin resistance in male gas station workers

Guo,

Li,

Cui

et al. 2024

Environ. Sci.: Processes Impacts

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Section: Discussionmentioning

confidence: 99%

MTBE exposure may increase the risk of insulin resistance in male gas station workers

Guo,

Li,

Cui

et al. 2024

Environ. Sci.: Processes Impacts

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“…Measurement of serum indicators: The serum sample was moved from the −80℃ refrigerator to the 4℃ refrigerator, and the serum was allowed to thaw for approximately 2 h. Then, the serum sample was centrifuged at a low speed at 3000 rpm for 10 min, and the supernatant was obtained for GLU, insulin, HSL, NEFA, TC, TG, LDL-C, and HDL-C kit protocols. The homeostasis model assessment of insulin resistance (HOMA-IR) was determined using the following formula: HOMA-IR = [fasting blood glucose (mmol/L) × fasting insulin (mU/L)]/22.5 (coefficient 22.5 is the correction factor) [ 49 , 50 , 51 ].…”

Section: Methodsmentioning

confidence: 99%

Anti-Obesity Effect and Mechanism of Chitooligosaccharides Were Revealed Based on Lipidomics in Diet-Induced Obese Mice

et al. 2023

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Chitooligosaccharide (COS) is a natural product from the ocean, and while many studies have reported its important role in metabolic diseases, no study has systematically elaborated the anti-obesity effect and mechanism of COS. Herein, COSM (MW ≤ 3000 Da) was administered to diet-induced obese mice by oral gavage once daily for eight weeks. The results show that COSM administration reduced body weight; slowed weight gain; reduced serum Glu, insulin, NEFA, TC, TG, and LDL-C levels; increased serum HSL and HDL-C levels; improved inflammation; and reduced lipid droplet size in adipose tissue. Further lipidomic analysis of adipose tissue revealed that 31 lipid species are considered to be underlying lipid biomarkers in COS therapy. These lipids are mainly enriched in pathways involving insulin resistance, thermogenesis, cholesterol metabolism, glyceride metabolism and cyclic adenosine monophosphate (cAMP), which sheds light on the weight loss mechanism of COS. The Western blot assay demonstrated that COSM intervention can improve insulin resistance, inhibit de novo synthesis, and promote thermogenesis and β-oxidation in mitochondria by the AMPK pathway, thereby alleviating high-fat diet-induced obesity. In short, our study can provide a more comprehensive direction for the application of COS in obesity based on molecular markers.

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“…Birthweight is an important predictor of fetal health and has been associated with various health outcomes later in life, including type 2 diabetes, cardiovascular disease, and cancer (Cheng et al, 2021;Hu et al, 2022). Telomeres are the protective caps at the ends of chromosomes implicated in these same health outcomes, with shorter telomeres associated with an increased risk of age-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Robust evidence supports a causal link between higher birthweight and longer telomere length: a mendelian randomization study

Zhang,

Zhang

et al. 2024

Front. Genet.

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BackgroundObservational studies have suggested a potential relationship between birthweight and telomere length. However, the causal link between these two parameters remains undefined. In this study, we use Mendelian Randomization (MR). This method employs genetic variants as instrumental variables, to explore the existence of causal associations and elucidate the causal relationship between birth weight and telomere length.MethodsWe used 35 single nucleotide polymorphisms (SNPs) as instrumental variables for birth weight. These SNPs were identified from a meta-analysis involving 153,781 individuals. Furthermore, we obtained summary statistics for telomere length from a study conducted on 472,174 United Kingdom Biobank participants. To evaluate the causal estimates, we applied the random effect inverse variance weighted method (IVW) and several other MR methods, such as MR-Egger, weighted median, and MR-PRESSO, to verify the reliability of our findings.ResultsOur analysis supports a significant causal relationship between genetically predicted birth weight and telomer3e length. The inverse variance weighted analysis results for birth weight (Beta = 0.048; 95%CI = 0.023 to 0.073; p < 0.001) corroborate this association.ConclusionOur study provides robust evidence supporting a causal link between higher birth weight and longer telomere length.

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Triglyceride-Glucose Index Correlate With Telomere Length in Healthy Adults From the National Health and Nutrition Examination Survey

Cited by 5 publications

References 44 publications

MTBE exposure may increase the risk of insulin resistance in male gas station workers

MTBE exposure may increase the risk of insulin resistance in male gas station workers

Anti-Obesity Effect and Mechanism of Chitooligosaccharides Were Revealed Based on Lipidomics in Diet-Induced Obese Mice

Robust evidence supports a causal link between higher birthweight and longer telomere length: a mendelian randomization study

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