Triglyceride-Glucose Index Correlate With Telomere Length in Healthy Adults From the National Health and Nutrition Examination Survey

Abstract

AimThe present investigation was designed to test the association between leukocyte telomere length (LTL) and two simple markers of insulin resistance, that is, homeostatic model assessment of insulin resistance (HOMA-IR) and triglyceride-glucose (TyG) index in U.S. adults without metabolic diseases.MethodsA total of 6489 U.S. adults without diabetes from NHANES 1999–2002 were analyzed. TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. HOMA-Index was calculated as fasting plasma glucose (mmol/L) × fasting serum insulin (mU/mL)/22.5. LTL was obtained using the quantitative polymerase chain reaction method. Multivariate linear regression analysis was assessed to evaluate the association of TyG index HOMA-IR with LTL. We further conducted a generalized additive model (GAM) and a fitted smoothing curve with penalized spline method.ResultsIt was found that the mean LTL was 5796.1 bp in the measured healthy adults. Overall, TyG index was significantly associated with LTL, while HOMA-IR was not. Compared with participants in tertile 1 of the TyG index, the β (95% CI) for those in the second (8.27 to 8.77) and third (≥ 8.77) were -4.31 (95% CI: -48.12~39.49) and -95.98 (95% CI: -145.08~-46.89), respectively. Subjects with TyG index ≥ 8.77 had statistically significant shorter LTL (β = -93.33, 95%CI: -134.33~-52.32), compared with TyG index < 8.77. We further explored a dose-response relation between TyG index by a decile approach [≤ 7.81 (reference), 7.81-8.04, 8.04-8.21, 8.21-8.37, 8.37-8.52, 8.52-8.68, 8.68-8.83, 8.83-9.03, 9.03-9.33, and >9.33] and LTL. Five subgroups (TyG index 7.81-8.04, 8.04-8.21, 8.21-8.37, 8.37-8.52, and 8.52-8.68) did not show significant effect on LTL; while there was a significantly shorter LTL for participants with the TyG index > 8.68, supporting a threshold effect of TyG index on LTL.ConclusionsThe results suggested that higher TyG index (> 8.68) was closely related to shorter LTL and the TyG index was better associated with LTL than HOMA-IR.

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“…Consistently, the tertile 3 of the TyG index, a biomarker of insulin resistance, was 8.77, and a high TyG index (>8.77), not HOMA-IR, was negatively and independently associated with leukocyte telomere length among non-diabetic U.S. adults from NHANES. 52 In an atherosclerosis cohort survey performed in the Shijingshan District in Beijing, the mean TyG index was 8.81. 53 In a cohort study in Sweden, the means TyG index of individuals with isolated impaired fasting glucose, with combined glucose intolerance, and with diabetes-treatment-naive T2D were 8.6 ± 0.04, 8.8 ± 0.06, and 9.2 ± 0.1, respectively.…”

Anti-Obesity Effect and Mechanism of Chitooligosaccharides Were Revealed Based on Lipidomics in Diet-Induced Obese Mice

“…Measurement of serum indicators: The serum sample was moved from the −80℃ refrigerator to the 4℃ refrigerator, and the serum was allowed to thaw for approximately 2 h. Then, the serum sample was centrifuged at a low speed at 3000 rpm for 10 min, and the supernatant was obtained for GLU, insulin, HSL, NEFA, TC, TG, LDL-C, and HDL-C kit protocols. The homeostasis model assessment of insulin resistance (HOMA-IR) was determined using the following formula: HOMA-IR = [fasting blood glucose (mmol/L) × fasting insulin (mU/L)]/22.5 (coefficient 22.5 is the correction factor) [ 49 , 50 , 51 ].…”

Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression

“…Additionally, we sought to examine the relationship of TL and TA to biological stress mediators, as well as markers of cardiometabolic risk, which are associated with both TL and TA in depressed individuals. The particular physiological/metabolic indices we assessed included Allostatic Load, Cardiometabolic Risk Score, and Triglyceride Index (TyG), each of which may be associated with TL and/or TA 45 – 47 .…”