The effects of prolonged administration of norepinephrine reuptake inhibitors on long-term potentiation in dentate gyrus, and on tests of spatial and object recognition memory in rats

Walling, Susan G.; Milway, J. Stephen; Ingram, Matthew L.; Lau, Catherine Y.; Morrison, Gillian L.; Martin, Gerard M.

doi:10.1016/j.nlm.2015.12.013

Cited by 6 publications

(4 citation statements)

References 48 publications

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“…Since the memory specificity impaired after NE infusion, animals could not restrict fear responses to the appropriate predictor-context, but present higher freezing in cue test. NE regulates synaptic plasticity and glutamatergic excitatory post-synaptic currents (EPSCs; Almaguer-Melian et al, 2005; Walling et al, 2016) through several pathways that are regulated by phosphorylation of the AMPARs (Esteban et al, 2003; Oh et al, 2006). GluR1 Ser831 and Ser845 phosphorylation sites have been proposed to play a key role in AMPAR trafficking and synaptic plasticity.…”

Section: Resultsmentioning

confidence: 99%

Norepinephrine Induces PTSD-Like Memory Impairments via Regulation of the β-Adrenoceptor-cAMP/PKA and CaMK II/PKC Systems in the Basolateral Amygdala

Liu

Zhu

Hao

et al. 2019

Front. Behav. Neurosci.

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Glucocorticoids (GCs) can modulate the memory enhancement process during stressful events, and this modulation requires arousal-induced norepinephrine (NE) activation in the basolateral amygdale (BLA). Our previous study found that an intrahippocampal infusion of propranolol dose-dependently induced post-traumatic stress disorder (PTSD)-like memory impairments. To explore the role of the noradrenergic system of the BLA in PTSD-like memory impairment, we injected various doses of NE into the BLA. We found that only a specific quantity of NE (0.3 μg) could induce PTSD-like memory impairments, accompanied by a reduction in phosphorylation of GluR1 at Ser845 and Ser831. Moreover, this phenomenon could be blocked by a protein kinase A (PKA) inhibitor or calcium/calmodulin-dependent protein kinase II (CaMK II) inhibitor. These findings demonstrate that NE could induce PTSD-like memory impairments via regulation of the β-adrenoceptor receptor (β-AR)-3′,5′-cyclic monophosphate (cAMP)/PKA and CaMK II/PKC signaling pathways.

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Section: Resultsmentioning

confidence: 99%

Norepinephrine Induces PTSD-Like Memory Impairments via Regulation of the β-Adrenoceptor-cAMP/PKA and CaMK II/PKC Systems in the Basolateral Amygdala

Liu

Zhu

Hao

et al. 2019

Front. Behav. Neurosci.

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“…; Wallings et al . ). The precise effect of noradrenaline on plasticity, as explored in animal models, is complex and depends on receptor subtype, concentration and site of action (Marzo et al .…”

Section: Introductionmentioning

confidence: 97%

“…Noradrenaline affects learning and memory processes via modulating long-term potentiation (LTP) and depression (LTD) (Tully et al 2007;Wallings et al 2016). The precise effect of noradrenaline on plasticity, as explored in animal models, is complex and depends on receptor subtype, concentration and site of action (Marzo et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Acute and chronic effects of noradrenergic enhancement on transcranial direct current stimulation‐induced neuroplasticity in humans

Kuo

Paulus

Batsikadze

et al. 2016

The Journal of Physiology

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Noradrenaline affects cognition and motor learning processes via its impact on long-term potentiation (LTP) and depression (LTD). We aimed to explore the impact of single dose and chronic administration of the selective noradrenaline reuptake inhibitor (NRI) reboxetine (RBX) on plasticity induced by transcranial direct current stimulation (tDCS) in healthy humans via a double-blinded, placebo-controlled, randomized crossover study. Sixteen healthy volunteers received placebo or single dose RBX (8 mg) before anodal or cathodal tDCS of the primary motor cortex. Afterwards, the same subjects took RBX (8 mg day ) consecutively for 21 days. During this period, two additional interventions were performed (RBX with anodal or cathodal tDCS), to explore the impact of chronic RBX treatment on plasticity. Plasticity was monitored by motor-evoked potential amplitudes elicited by transcranial magnetic stimulation. Chronic administration of RBX increased and prolonged the LTP-like plasticity induced by anodal tDCS for over 24 h. Chronic RBX significantly converted cathodal tDCS-induced LTD-like plasticity into facilitation, as compared to the single dose condition, for 120 min after stimulation. The results show a prominent impact of chronic noradrenergic enhancement on plasticity of the human brain that might partially explain the delayed therapeutic impact of selective NRIs in depression and other neuropsychiatric diseases.

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“…Noradrenaline affects learning and memory processes via modulating long-term potentiation (LTP) and depression (LTD) (Tully et al, 2007;Wallings et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Effects of Serotonin and Noradrenaline on Neuroplasticity and Excitability of The Primary Motor Cortex in Humans

Kuo¹

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Number of references: 43Table : 1 Figures: 5 excitability, increased the slope of the I-O curve, ICF, and I-wave facilitation, but decreased SICI and SAI. Moreover, chronic RBX showed a more stable enhancement of ICF and I-wave facilitation as compared to single dose application. Conclusions:The results might explain possible mechanisms underlying the beneficial effect of RBX in neurological and psychiatric diseases.

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The effects of prolonged administration of norepinephrine reuptake inhibitors on long-term potentiation in dentate gyrus, and on tests of spatial and object recognition memory in rats

Cited by 6 publications

References 48 publications

Norepinephrine Induces PTSD-Like Memory Impairments via Regulation of the β-Adrenoceptor-cAMP/PKA and CaMK II/PKC Systems in the Basolateral Amygdala

Norepinephrine Induces PTSD-Like Memory Impairments via Regulation of the β-Adrenoceptor-cAMP/PKA and CaMK II/PKC Systems in the Basolateral Amygdala

Acute and chronic effects of noradrenergic enhancement on transcranial direct current stimulation‐induced neuroplasticity in humans

Effects of Serotonin and Noradrenaline on Neuroplasticity and Excitability of The Primary Motor Cortex in Humans

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