The effects of prenatal marijuana exposure on delinquent behaviors are mediated by measures of neurocognitive functioning

Day, Nancy L.; Leech, Sharon L.; Goldschmidt, Lidush

doi:10.1016/j.ntt.2010.07.006

Cited by 125 publications

(101 citation statements)

References 66 publications

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“…Indeed, prenatal cannabinoid exposure is associated with lower IQs and delinquent behaviors in children [2,3]. Moreover, adolescent cannabis use is associated with an increased risk of developing schizophrenia and/or accelerated onset of symptoms [5,46,47,48,49].…”

Section: Discussionmentioning

confidence: 99%

“…Although prenatal exposure is associated with negative effects on fetal brain development in humans [2,3,4,5,6,7,8,9], cannabis use is self-reported by over 25% of pregnant women [10]. The major psychoactive ingredient in cannabis is Δ9-tetrahydrocannabinol (THC), which acts primarily via the G-protein coupled cannabinoid receptor 1 (CB1R) [11], signaling via the activation of ERK kinases and/or the inhibition of adenyl cyclase (reviewed in [12,13]).…”

Section: Introductionmentioning

confidence: 99%

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THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons

et al. 2017

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Given the cognitive and behavioral effects following in utero Δ9-tetrahydrocannabinol (THC) exposure that have been reported in humans and rodents, it is critical to understand the precise consequences of THC on developing human neurons. Here, we utilize excitatory neurons derived from human-induced pluripotent stem cells (hiPSCs), and report that in vitro THC exposure reduced expression of glutamate receptor subunit genes (GRIA1, GRIA2, GRIN2A, and GRIN2B). By expanding these studies across hiPSC-derived neurons from individuals with a variety of genotypes, we believe that a hiPSC-based model will facilitate studies of the interaction of THC exposure and the genetic risk factors underlying neuropsychiatric disease vulnerability.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons

et al. 2017

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“…Some evidence for decreased height has been found in children with prenatal exposure [15,16]. Minimum evidence exists on a significant association between prenatal and/or breastfeeding marijuana exposure and risk for stillbirth, SIDS, development of depression, delinquent behavior, congenital heart lesions, psychosis, or future marijuana use [17][18][19][20][21][22][23][24][25]. Limited evidence also exists for preterm and low birth weight [26][27][28][29][30][31][32][33][34][35][36].…”

Section: Pregnancy and Breastfeedingmentioning

confidence: 99%

Pediatric Concerns Due to Expanded Cannabis Use: Unintended Consequences of Legalization

Wang

2016

J. Med. Toxicol.

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An "unintended consequence" of marijuana legalization is the impact on the pediatric population. From prenatal exposure to unintentional childhood exposures, through concerns of adolescence abuse and marijuana use for medicinal indications in children, marijuana exposure can affect pediatric patients at every stage in childhood. Regardless of the stage or reason of exposure, concerns exist about short-term and long-term consequences in a child's physical and mental health. The use of cannabidiol (CBD) may have some benefit for the treatment of epilepsy, but emphasis needs to be on rigorous clinical trials to evaluate efficacy and safety. As more states allow both medical and recreational marijuana, availability and prevalence of use will likely increase and more surveillance and research is needed to evaluate the consequences on the pediatric population.

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“…Day et al (2011) investigaram a hipótese da existência de uma relação entre a exposição pré-natal à maconha e a realização de atos infracionais na adolescência de jovens por terem o desenvolvimento neurocognitivo do feto comprometido por causa da exposição à droga durante a gestação. Os autores encontraram que, aos 10 anos, havia uma tendência dos adolescentes a apresentarem sintomas depressivos e problemas de atenção.…”

Section: Fatores Biológicosunclassified

Relações familiares de adolescentes cumprindo medida socioeducativa restritiva de liberdade: uma revisão narrativa da literatura

Castro

Teodoro

2014

Temas Psicol.

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ResumoO objetivo deste artigo foi realizar uma revisão narrativa sobre a relação entre o sistema familiar e a conduta infracional de jovens. Foram consultadas as bases de dados SciELO; LILACS; BVS; PePSIC; PsycNET; APA PsycNET; Science Direct e Web of Knowledge (ISI). Resultaram da busca 19 artigos que atenderam aos critérios de inclusão. A análise dos artigos mostrou que alguns fatores familiares comumente encontram-se associados à condição de infrações à lei e ao cumprimento de medida sócio-educativa de internação pelos adolescentes. São eles: os sócio-econômicos, a estrutura familiar, a violência intrafamiliar, as práticas educacionais e monitoramento parental, a fragilidade dos vínculos familiares, os familiares em confl ito com a lei e os fatores biológicos. Assim, pode-se constatar que a família, ao não cumprir sua função de proteção, passa a ser considerada um fator de risco ao bem-estar de muitas crianças e adolescentes. Palavras-chave:Relações familiares, violência, adolescentes em confl ito com a lei. Family Relationships of Adolescents under Socio-ConstrainedFreedom: A Systematic Narrative Review AbstractThe purpose of this article was to realize a narrative review of the relation between the family system and the criminal conduct of adolescents. There were used the data bases: SciELO; LILACS; BVS; PePSIC; PsycNET; APA PsycNET; Science Direct and Web of knowledge (ISI). The search resulted on 19 articles that complied the inclusion criteria. The articles' analysis showed that some family factors are commonly found associated with law infraction and fulfi llment of social educative freedom restriction measures by the adolescents. They are: socioeconomics level, family structure, domestic violence; educational practices and parental control, the frailty of family bonds, family members in confl ict with the law, and biologic factors. So, it could be stated that when the family doesn't fulfi ll its protective function, it starts to be seen as a risk factor to the well-being of many children and adolescents.

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The effects of prenatal marijuana exposure on delinquent behaviors are mediated by measures of neurocognitive functioning

Cited by 125 publications

References 66 publications

THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons

THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons

Pediatric Concerns Due to Expanded Cannabis Use: Unintended Consequences of Legalization

Relações familiares de adolescentes cumprindo medida socioeducativa restritiva de liberdade: uma revisão narrativa da literatura

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