The Effects of Polyethylene Glycosylated Creatine Supplementation on Anaerobic Performance Measures and Body Composition

Camic, Clayton L.; Housh, Terry J.; Zúñiga, Jorge M.; Traylor, Daniel A.; Bergstrom, Haley C.; Schmidt, Richard J.; Johnson, Glen O.; Housh, Dona J.

doi:10.1519/jsc.0b013e3182a361a5

Cited by 20 publications

(15 citation statements)

References 35 publications

(109 reference statements)

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“…However, three other types of supplementation were cited in four studies: polyethylene glycosylated creatine [23], di-creatine citrate [22], and creatine phosphate [24].…”

Section: Type Of Supplementationmentioning

confidence: 99%

See 1 more Smart Citation

Creatine Supplementation and Upper Limb Strength Performance: A Systematic Review and Meta-Analysis

Lanhers¹,

Pereira²,

Naughton³

et al. 2016

Sports Med

101

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“…However, three other types of supplementation were cited in four studies: polyethylene glycosylated creatine [23], di-creatine citrate [22], and creatine phosphate [24].…”

Section: Type Of Supplementationmentioning

confidence: 99%

“…Only 38 studies had a maintenance dose, which varied between 1.25 and 27.0 g/day [23,27]. The quantity of the maintenance dose varied more between studies compared with the loading dose.…”

Section: Maintenance Dosementioning

confidence: 99%

Creatine Supplementation and Upper Limb Strength Performance: A Systematic Review and Meta-Analysis

Lanhers¹,

Pereira²,

Naughton³

et al. 2016

Sports Med

101

View full text Add to dashboard Cite

show abstract

“…Elevated phosphocreatine leads to the phosphorylation of ADP to ATP and aids in limiting energy depletion during rapid muscle movement. Multiple studies have indicated significant improvements in sprint performance, body mass, fat-free body mass, weightlifting volumes, oxygen uptake and overall exercise performance following creatine supplementation 29 – 40 . Creatine loading in athletes can require 20 grams per day of supplementation, while maintenance dosing is roughly 5 grams per day.…”

Section: Physiological Creatine Concentrations and Creatine Supplemenmentioning

confidence: 99%

A review of creatine supplementation in age-related diseases: more than a supplement for athletes

2014

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Creatine is an endogenous compound synthesized from arginine, glycine and methionine. This dietary supplement can be acquired from food sources such as meat and fish, along with athlete supplement powders. Since the majority of creatine is stored in skeletal muscle, dietary creatine supplementation has traditionally been important for athletes and bodybuilders to increase the power, strength, and mass of the skeletal muscle. However, new uses for creatine have emerged suggesting that it may be important in preventing or delaying the onset of neurodegenerative diseases associated with aging. On average, 30% of muscle mass is lost by age 80, while muscular weakness remains a vital cause for loss of independence in the elderly population. In light of these new roles of creatine, the dietary supplement’s usage has been studied to determine its efficacy in treating congestive heart failure, gyrate atrophy, insulin insensitivity, cancer, and high cholesterol. In relation to the brain, creatine has been shown to have antioxidant properties, reduce mental fatigue, protect the brain from neurotoxicity, and improve facets/components of neurological disorders like depression and bipolar disorder. The combination of these benefits has made creatine a leading candidate in the fight against age-related diseases, such as Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, long-term memory impairments associated with the progression of Alzheimer’s disease, and stroke. In this review, we explore the normal mechanisms by which creatine is produced and its necessary physiology, while paying special attention to the importance of creatine supplementation in improving diseases and disorders associated with brain aging and outlining the clinical trials involving creatine to treat these diseases.

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“…However, unlike our study, the participants were untrained and used a creatine supplement with a polyethylene glycol compound (1.25 and 2.50 g/day for >30 days). They also found that the placebo group had a significant increase in maximum strength; however, only the groups supplemented with creatine showed improvement in resistance to upper limb fatigue (26).…”

Section: Discussionmentioning

confidence: 97%

Effects of Low-Dose Creatine Monohydrate on Muscle Strength and Endurance

et al. 2018

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To investigate the effect of low-dose supplementation of creatine monohydrate without the use of the saturation phase, 36 male university students engaged in resistance training (age 22.5 ± 4.3 years, height 1.76 ± 0.08 m, weight 77.0 ± 11.0 kg, and body mass index 24.6 ± 2.5 kg/m 2 ) were randomly divided into three groups: group placebo (GP), group supplemented with creatine 3 g/day (3G), and group supplemented with 5 g/day creatine (5G). The subjects were tested for maximum muscle strength (1RM), upper body muscle endurance (MPU), and abdominal muscle endurance (MSU) before and after 7, 14, 21, 28, and 35 days of creatine supplementation or placebo and performing standardized resistance training. After 35 days of supplementation and training, all groups showed a significant improvement in the 1RM test; however, the percentages of strength increase were significantly higher (P < 0.05) in the groups supplemented with creatine (G3, ∆% 1RM = 20.0 ± 4.0; G5, ∆% 1RM = 19.9 ± 1.5) than in the placebo group (GP, ∆% 1RM = 10.3 ± 1.9). Upper limb muscle endurance showed a significant improvement only in 5G, ranging from 39.9 ± 7.9 MPU/min to 50.7 ± 11.0 MPU/min after 35 days of supplementation. Interestingly, abdominal muscle endurance showed no increase in any of the groups (GP, P > 0.528; G3, P > 0.076; G5, P > 0.148). These results support a number of earlier studies that demonstrated that creatine supplementation at low doses and without the use of the loading phase are effective for increasing maximal strength and endurance of upper limbs.

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The Effects of Polyethylene Glycosylated Creatine Supplementation on Anaerobic Performance Measures and Body Composition

Cited by 20 publications

References 35 publications

Creatine Supplementation and Upper Limb Strength Performance: A Systematic Review and Meta-Analysis

Creatine Supplementation and Upper Limb Strength Performance: A Systematic Review and Meta-Analysis

A review of creatine supplementation in age-related diseases: more than a supplement for athletes

Effects of Low-Dose Creatine Monohydrate on Muscle Strength and Endurance

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