The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia

Alahmar, Ahmed T

doi:10.5653/cerm.2018.45.2.57

Cited by 48 publications

(39 citation statements)

References 76 publications

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“…Approximately 15% of couples worldwide are unable to conceive due to infertility and males contribute to 50% of the infertility cases 20,21 . There are several causative factors for male infertility, including genetic and environmental factors [21][22][23][24] .…”

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confidence: 99%

Potential Pathogenic Bacteria in Seminal Microbiota of Patients with Different Types of Dysspermatism

Yang

Zhang

Xue

et al. 2020

Sci Rep

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Human microbiota play an important role in the health of their human hosts. Recent studies have demonstrated that microbiota exist in seminal plasma. The current study aims to elucidate whether seminal microbiota exist in patients with different types of dysspermatism and whether bacterial biomarkers can be identified for them. A total of 159 study participants were recruited, including 22 patients with oligoasthenospermia, 58 patients with asthenospermia, 8 patients with azoospermia, 13 patients with oligospermia, and 58 matched healthy controls. Seminal microbiota composition was analyzed using 16S rRNA gene-based sequencing. The results showed that the composition of seminal microbiota of patients with dysspermatism differed from those of healthy controls. Comparison of the microbiota composition in semen samples from patients with different types of dysspermatism showed that microbiota in patients with asthenospermia and oligoasthenospermia were distinct from healthy controls in beta diversity (P < 0.05). Characteristic biomarkers, including Ureaplasma, Bacteroides, Anaerococcus, Finegoldia, Lactobacillus and Acinetobacter lwoffii, were identified based on LEfSe analysis. Inferred functional analysis based on seminal microbiome data further indicated the presence of potential pathogenic biomarkers in patients with asthenospermia and oligoasthenospermia. These results provided profiles of seminal microbiota exhibited in different types of dysspermatism, thus providing new insights into their pathogenesis. Human microbiota, with its diverse relationships-commensal, parasitic, mutualistic, and pathogenic-play an important role in human health. Recent studies have reported that microbiota exist in almost every part of human body-even in the endocrine niche, such as in tumors, blood, and synovial fluid 1-4. Advances in technology and new research have demonstrated that microbiota are found in seminal plasma, and play an important role in host homeostasis 5. It has been demonstrated that the presence of bacteria in sperm is associated with male infertility 6. Some bacteria in the urogenital tract may affect spermatogenesis and decrease sperm quality through various means, including decrease in sperm motility, deficiency in DNA integrity, and destruction of mitochondrial function 7. Escherichia coli, Mycoplasma genitalium, Ureaplasma urealyticum, Mycoplasma hominis, Staphylococcus aureus, and Chlamydia trachomatis are pathogens associated with male infertility 8-12. Several studies using high-throughput sequencing have demonstrated that seminal plasma has a bacterial community, which includes Lactobacillus, Pseudomonas, Prevotella, and Gardnerella, among others 13-19 .

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confidence: 99%

Potential Pathogenic Bacteria in Seminal Microbiota of Patients with Different Types of Dysspermatism

Yang

Zhang

Xue

et al. 2020

Sci Rep

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“…Future directions include identifying the underlying molecular mechanisms that explain the speci c effects of some antioxidants on semen parameters [53]. Once a male has been pointed as having oxidative stress related infertility, treatment strategy should comprehend identi cation, modi cation and amelioration of the underlying cause before considering antioxidant supplements.…”

Section: Discussionmentioning

confidence: 99%

Oral Antioxidants Mitigate Levels of Malonedialdehyde and Protein Carbonyl and Improve Semen Parameters in Men with Oligoasthenozoospermia

Zhaku¹,

Beadini²,

Beadini³

et al. 2020

Preprint

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Raising awareness about treating options in North Macedonia, while sperm parameters are decreasing because of increased oxidative stress, in a terrain like this, represents a big challenge. All the patients that fulfilled the required criteria, 37 were enrolled in the study signing a document that explains nature of the study. The first semen sample was collected with at least three days of abstinence. From the sample 0.5 ml was used for standard semen analysis, 1.2 ml was used to evaluate the levels of malonedialdehyde (MDA) and protein carbonyl (PC). The last sample was collected after 6 months. Mean, Standard Deviation, the Pearson Correlation and an independent student t-test were used for statistical analyses. Concentration and motility were significantly increased after 6 months of treatment (p<0.001).The level of MDA shows significantly lower values after six months of therapy with antioxidants (p<0.001).Whereas another marker which is denoted by PC was also lower after the treatment, but was not statistically significant (p=0.0554). There is, however, lack of agreement, because improvement is not consistent and there is wide variation in the treatment regimens, on the dose and duration of treatment and whether mono or combined oral antioxidants should be administered. Always keep on mind that, antioxidants are not free from potential side effects “antioxidant paradox”.

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“…В ходе этих исследований изучено влияние применения как монокомпонентных, так и комбинированных антиоксидантов (L-карнитин, коэнзим Q10, цинк, селен, витамин Е) на качественные и количественные параметры спермы у мужчин с идиопатической олигоастенотератозооспермией. На основании этого автор отметил преимущество применения комбинирован-ных антиоксидантов для увеличения подвижности и концентрации сперматозоидов по сравнению с использованием монокомпонентных антиоксидантов [11].…”

Section: The Use Of Antioxidant Therapy As Preconceptional Care In Menunclassified

The use of antioxidant therapy as preconceptional care in men

Efremov¹,

Kasatonova²,

Mel'nik³

et al. 2018

Probl. reprod.

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In this literature review, the effect of complex antioxidant therapy aimed at correcting oxidative stress, replenishing vitamin deficiencies, trace elements and low molecular weight peptides, has been studied, resulting in damage to the DNA of spermatozoa. In turn, low DNA integrity indicators are associated with a decrease in the probability of natural conception, a decrease in the fertilizing capacity of sperm, an increase in the frequency of embryonic developmental disorders and miscarriages, and an increase in the likelihood of developing cancer in neonates.

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The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia

Cited by 48 publications

References 76 publications

Potential Pathogenic Bacteria in Seminal Microbiota of Patients with Different Types of Dysspermatism

Potential Pathogenic Bacteria in Seminal Microbiota of Patients with Different Types of Dysspermatism

Oral Antioxidants Mitigate Levels of Malonedialdehyde and Protein Carbonyl and Improve Semen Parameters in Men with Oligoasthenozoospermia

The use of antioxidant therapy as preconceptional care in men

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