The use of antioxidant therapy as preconceptional care in men

Efremov, E.A.; Kasatonova, E. V.; Mel'nik, Ja I; Kastrikin, Yu.V.; Khizriev, Kh. Z.

doi:10.17116/repro20182404189

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Во многих исследованиях оценивалась эффективность антиоксидантов в лечении мужского бесплодия или подготовке к зачатию [36]. В большинстве из этих исследований было продемонстрировано улучшение по одному или нескольким параметрам спермограммы [37][38][39]. Однако есть и такие исследования, в которых положительного эффекта отмечено не было [40,41].…”

Section: антиоксидантная терапия при мужском бесплодииunclassified

Sperm oxidative stress: clinical significance and management

Гамидов¹,

Shatylko²,

Попова³

et al. 2021

Medicinskij sovet

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Oxidative stress is one of the leading causes of sperm dysfunction. Excessive amounts of reactive oxygen species can damage sperm membranes and disrupt their DNA integrity, which affects not only the likelihood of getting pregnant naturally, but also the clinical outcomes of assisted reproductive technologies and the risk of miscarriage. Sperm cells are extremely vulnerable to oxidative stress, given the limited functional reserve of their antioxidant systems and the DNA repair apparatus. Lifestyle factors, most of which are modifiable, often trigger generation of reactive oxygen species. Both the lifestyle modification and use of antioxidant dietary supplements are adequate and compatible ways to combat male oxidative stress-associated infertility. The search for other internal and external sources of reactive oxygen species, the identification of the etiology of oxidative stress and treatment of respective diseases are necessary for the successful regulation of redox processes in the male reproductive system in clinical practice, which is required not only to overcome infertility, but also to prevent induced epigenetic disorders in subsequent generations. The article presents the analysis of the molecular mechanisms of male idiopathic infertility. The authors provide an overview of how to prevent oxidative stress as one of the causes of subfebrile fever. The article provides an overview of modern therapeutics, as well as the options for eliminating the consequences of the effect of reactive oxygen species on spermatogenesis and male reproductive system in general.

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Section: антиоксидантная терапия при мужском бесплодииunclassified

Sperm oxidative stress: clinical significance and management

Гамидов¹,

Shatylko²,

Попова³

et al. 2021

Medicinskij sovet

View full text Add to dashboard Cite

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The role of antioxidant molecules in the treatment of male infertility and the preparation of a man for conception

et al. 2020

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Empirical therapy of male infertility is used as a stand-alone type of treatment in idiopathic infertility, and in other situations can complement basic therapy. There are well-known pathogenetic methods of male infertility treatment applied in case of reproductive gland infection, hypogonadotropic hypogonadism, ejaculation disorders. However, the prospects of empirical treatment of male infertility are not fully clear. Combined antioxidant drugs are very popular, which include a wide range of similar substances. However, their molecules significantly differ from each other in structure, chemical properties and set of biological functions, therefore, there is a number of questions that deserve separate discussion regarding their compatibility with each other. Antioxidants such as various water-soluble and fat-soluble vitamins, coenzyme Q10, zinc and carnitines are widely used in its composition to reduce sperm damage caused by oxidative stress. They are widely available and inexpensive compared to other methods of treatment. Although there are no results of large randomized controlled trials yet, there is some evidence that taking oral antioxidoidants improves the basic parameters of sperm and increases the frequency of childbirth. There are many antioxidant supplements in different dosage forms, with different compositions and modes of use. In this article, we have analyzed the effect of the main antioxidant substances used on semen parameters, the need for their combined use and the role of these substances in the body.

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The role of antioxidants in the treatment of infertile men with varicocele

et al. 2021

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Varicocele is a common disease that occurs in 35–40% of men with primary infertility and in 80% of men with secondary infertility Disturbance of microcirculation in the testicles, which occurs during varicocele, lead to ischemia and hypoxia of the testicles, which provoke degenerative changes in all testicular cell populations. Retrograde blood flow from the testicular vein and the external spermatic vein into pampiniform venous plexus leads to an increase of hydrostatic pressure in the testicular vascular system and rise of temperature, and it also contributes to the development of sterile inflammation. Oxidative stress, nitrosative stress, and hypoxia are generally recognized elements of the pathogenesis of infertility associated with varicocele. It is known that when the supraphysiological level of reactive oxygen species in the ejaculate is reached, their concentration disrupts the structure and function of spermatozoa. Nitric oxide (NO) is involved in the regulation of body temperature, NO-dependent mechanisms may contribute to the increased scrotal temperature during varicocele. The physiological concentration of NO pro duced by testicular macrophages stimulates steroidogenesis in Leydig cells. However, in the presence of certain reactive oxygen species, NO can transform into peroxynitrite and other strong cytotoxic metabolites, which lead to dysregulation of testosterone synthesis involved in spermatogenesis. Also, manifestations of varicocele among infertile men have decreased expression levels of the testis-specific heat-shock protein, HSPA2, and abnormal methylation of sperm DNA. Therefore, the use of combined anti oxidant supplements as part of adjuvant therapy after surgical treatment or as an independent application in some clinical cases appears to be an adequate strategy to optimize fertility in patients with varicocele. In this review, we evaluated the importance of various antioxidants, such as vitamin E, folic acid, carnitine, inositol, arginine, acetylcysteine, zinc, selenium in spermatogenesis and their effect on reproductive function during varicocele.

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The use of antioxidant therapy as preconceptional care in men

Cited by 3 publications

References 21 publications

Sperm oxidative stress: clinical significance and management

Sperm oxidative stress: clinical significance and management

The role of antioxidant molecules in the treatment of male infertility and the preparation of a man for conception

The role of antioxidants in the treatment of infertile men with varicocele

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