The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome

Talari, Hamid Reza; Poladchang, Somayyeh; Hamidian, Yaser; Samimi, Mansooreh; Gilasi, Hamid Reza; Ebrahimi, Faraneh Afshar; Asemi, Zatollah

doi:10.5001/omj.2018.88

Cited by 21 publications

(25 citation statements)

References 41 publications

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“…In patients with PCOS, carotid IMT has been evaluated in many studies. Talari et al (19) found that the carotid artery IMT increased in patients with PCOS compared to the control group). In the study conducted by Talbott et al (20), the increase in carotid IMT was shown among women over 45 years of age with PCOS compared to the control group, but not in women with PCOS in the 30-44 years age group.…”

Section: Discussionmentioning

confidence: 96%

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The Effects of Metformin, Ethinyl Estradiol/Cyproterone Acetate, and Metformin Ethinyl Estradiol/Cyproterone Acetate Combination Therapy on Carotid Artery Intima-media Thickness in Patients with Polycystic Ovary Syndrome

Ünal¹,

Demirci²,

Yılmaz³

et al. 2020

Istanbul Med J

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Polikistik over sendromu, karotis arter intima media kalınlığı, insülin direnci, apelin, adiponektin, C-reaktif protein treatment groups (p>0.05). There was no statistically significant change in carotid IMT value in all treatment groups (p>0.05). Conclusion: According to these results, we can say that women with PCOS have subclinical atherosclerosis and that metformin treatment has a positive effect on subclinical atherosclerosis.

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Section: Discussionmentioning

confidence: 96%

“…The majority of the studies in PCOS have shown increased levels of CRP (19,25). In a meta-analysis, it was found that increased CRP levels decreased in patients with PCOS after metformin treatment (25).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Metformin, Ethinyl Estradiol/Cyproterone Acetate, and Metformin Ethinyl Estradiol/Cyproterone Acetate Combination Therapy on Carotid Artery Intima-media Thickness in Patients with Polycystic Ovary Syndrome

Ünal¹,

Demirci²,

Yılmaz³

et al. 2020

Istanbul Med J

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“…In this stage, the Kappa coefficient of agreement between the two investigators was 0•933. Eighteen RCT were selected for full-text reading after analysis of the abstracts; eight studies were excluded for not fulfilling the inclusion criteria, and thus, ten (33)(34)(35)(36)(37)(38)(39)(40)(41)(42) randomised clinical trials were included in this systematic review with meta-analysis.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…One study (42) was included as two independent reports because the findings were described by different interventions of interest (flaxseed and fish oils). The total sample size of all studies comprised 381 patients diagnosed with PCOS (nine studies (33)(34)(35)(36)(37)(38)(39)(40)(41) diagnosed by the Rotterdam criteria and one study (42) by the National Institutes of Health criteria) with a mean age of 27•05 years and 384 controls with a mean age of 27•10 years. All the included studies were parallel RCT that comprised 6-12 weeks of follow-up.…”

Section: Study Characteristicsmentioning

confidence: 99%

Influence of n-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with polycystic ovary syndrome: a systematic review and meta-analysis

et al. 2020

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Polycystic ovary syndrome (PCOS) is defined as a reproductive endocrine disease that results in a low-grade inflammatory and prooxidant state. Dietary factors, including omega-3 fatty acids, may have a key role in improving metabolic disorders in PCOS patients. The present study aimed to investigate the influence of omega-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with PCOS. A systematic literature search of Medline/PubMed, Cochrane Central Register of Controlled Trials, Scopus and Lilacs, until November 2019, was conducted. Randomized clinical trials that reported inflammatory and oxidative stress markers as endpoints in women with PCOS receiving omega-3 fatty acid supplementation were included. The pooled estimates of the weighted mean differences (WMD) and the standard mean differences (SMD) were calculated. Random effect models were adopted to measure the pooled outcomes. Among the 323 studies retrieved, 10 fulfilled the inclusion criteria for a meta-analysis. We founded a significant decrease in high-sensitivity C-reactive protein (hs-CRP) [SMD: −0.29 (95%CI: −0.56 to −0.02) mg/L] and an increase of adiponectin [WMD: 1.42 (95%CI 1.09 to 1.76) ng/ml] concentrations in the intervention group when compared with the placebo group. No statistically significant results were found in the meta-analysis for visfatin, nitric oxide (NO), glutathione (GSH) or malondialdehyde (MDA) levels or total antioxidant capacity (TAC). The data suggest that supplementation of omega-3 fatty acids could reduce the inflammatory state in women with PCOS, through a decrease in hs-CRP and an increase in adiponectin levels.

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“…For example, those subjects with a family history of a premature CAD and a high level of subclinical vascular damage may be directed for early treatment, such as statin (Mulders et al 2012). Subclinical vascular damage can also be an assessment tool, in order to determine the effects of any supplement (Talari et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Vascular Markers among Young Women with CVD Risk Factors

Aminuddin¹,

Ugusman²,

Salamt³

et al. 2019

JSM

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Data pertaining to carotid intima-media thickness (CIMT), carotid-femoral pulse wave velocity (PWVcf), augmentation index (AI), and C-reactive protein (CRP) are less studied among young Asian women. The objectives of this study were to determine the associations between these vascular markers with other cardiovascular (CVD) risk factors and future CVD risks; and secondly, to determine the associations between the markers themselves among young women. One hundred and forty-eight young women who were healthy, or having any CVD risk factor, were recruited. They were divided into a healthy group (HG, n=71) and a risk group (RG, n=77). The parameters measured included body anthropometry, blood pressure (BP), CIMT, PWVcf, AI, CRP, blood sugar, and lipid profiles. The future CVD risk was expressed in short and long term Framingham Risk Scores (FRS). The data was analysed via SPSS and p-value <0.05 was accepted as significant. The RG had significantly higher PWVcf, AI, and hs-CRP when compared to HG. All of the markers were associated with CVD risk factors and the long-term FRS. The independent variable for CIMT was age (R 2 =0.11), while PWVcf was determined by diastolic BP and age (R 2 =0.29). AI was independently determined by age, heart rate, and LDL (R 2 =0.28), while for CRP, it was weight and HDL (R 2 =0.30). In conclusion, among the young women with CVD risk factor, CIMT, PWVcf, AI, and hs-CRP can be used to assess their risk of future CVD. No associations were observed between the markers themselves, which suggests that every marker reflects a different entity. They should be measured independently for a complete vascular assessment. ABSTRAKMaklumat berkaitan ketebalan intima media arteri karotid (CIMT), halaju gelombang nadi arteri karotid femor (PWVcf), indeks augmentasi (AI) dan protein C-Reaktif (CRP) kurang dikaji dalam kalangan belia wanita Asia. Objektif kajian ini adalah menentukan hubungan antara penanda saluran darah tersebut dengan faktor-faktor risiko CVD yang lain serta risiko CVD pada masa depan, dan kedua adalah untuk menentukan hubungan penanda saluran darah tersebut sesama sendiri dalam kalangan wanita muda. Seramai seratus empat puluh lapan wanita muda yang sihat atau mempunyai faktor risiko CVD direkrut. Mereka dibahagikan kepada kumpulan sihat (HG, n=71) dan kumpulan berisiko (RG, n=77). Parameter yang diukur meliputi antropometri badan, tekanan darah (BP), CIMT, PWVcf, AI, CRP, glukosa darah dan profil lipid. Risiko CVD pada masa depan dibentangkan dalam bentuk Skor Risiko Framingham (FRS) jangka masa panjang dan pendek. Data dianalisis menggunakan SPSS dan nilai p<0.05 diterima sebagai signifikan. Kumpulan RG mempunyai PWVcf, AI dan Hs-CRP yang lebih tinggi apabila dibandingkan dengan HG. Kesemua penanda saluran darah ini mempunyai hubungan dengan faktor risiko CVD dan FRS jangka masa panjang. Variabel tidak bersandar bagi CIMT adalah umur (R 2 =0.11) sementara PWVcf ditentukan oleh BP diastolik dan umur (R 2 =0.29). AI ditentukan secara bebas oleh umur, kadar nadi dan LDL (R 2 =0.30) manak...

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The Effects of Omega-3 and Vitamin E Co-supplementation on Carotid Intima-media Thickness and Inflammatory Factors in Patients with Polycystic Ovary Syndrome

Cited by 21 publications

References 41 publications

The Effects of Metformin, Ethinyl Estradiol/Cyproterone Acetate, and Metformin Ethinyl Estradiol/Cyproterone Acetate Combination Therapy on Carotid Artery Intima-media Thickness in Patients with Polycystic Ovary Syndrome

The Effects of Metformin, Ethinyl Estradiol/Cyproterone Acetate, and Metformin Ethinyl Estradiol/Cyproterone Acetate Combination Therapy on Carotid Artery Intima-media Thickness in Patients with Polycystic Ovary Syndrome

Influence of n-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with polycystic ovary syndrome: a systematic review and meta-analysis

Vascular Markers among Young Women with CVD Risk Factors

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