The Effects of Natural Clinoptilolite and Nano-Sized Clinoptilolite Supplementation on Glucose Levels and Oxidative Stress in Rats With Type 1 Diabetes

Nia, Behnoosh Hossein; Khorram, Sirous; Rezazadeh, Hassan; Safaiyan, Abdolrasol; Tarighat‐Esfanjani, Ali

doi:10.1016/j.jcjd.2017.01.010

Cited by 20 publications

(10 citation statements)

References 44 publications

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“…Zeolite was used in our study for the following reasons: zeolite is capable of adsorbing many different types of gas, moisture, petrochemicals, heavy metals and radioactive elements and a multitude of various compounds; it has a total cation-exchange capacity of about 200 mEq. The exchange capacity plays an important role in the therapeutic use of zeolite, accounting for its ability to release useful elements while capturing and binding others [ 54 , 55 ].…”

Section: Resultsmentioning

confidence: 99%

Does supplemental zeolite (clinoptilolite) affect growth performance, meat texture, oxidative stress and production of polyunsaturated fatty acid of Turkey poults?

et al. 2018

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BackgroundFollowing the ban on the use of growth factors, the use of zeolite in poultry feed could be a solution to obtain healthier food products that are more demanded by the consumer.MethodsZeolite (Clinoptilolite) was added to turkey male and female feed at concentrations 1% or 2% and was evaluated for its effectiveness on performance of the production. The turkeys were given free and continuous access to a nutritionally non-limiting diet (in meal form) that was either a basal diet or a ‘Zeolite supplemented-diet’ (the basal diet supplemented with clinoptilolite at a level of 1% or 2%).ResultsIt was found that adding zeolite in the turkey diet had a positive effect on growth performance and increased weight gain compared to the control. In addition, zeolite treatment had a positive effect on oxidative stress and organoleptic parameters that were measured. It was found that adding zeolite in the turkey diet reduced the MDA level in the liver and in the meat, as compared to the control. Quality of meat was measured as a significantly increase (p < 0.05) in pH for male meat, indicated that the zeolite could maintain the quality of longer period. The adding of zeolite in the turkey diet increased level of polyunsaturated fatty acid.ConclusionThis study showed the significance of using zeolite, as a feed additive for turkey, as part of a comprehensive program to improve growth performance and oxidative stress parameters and to increase level of polyunsaturated fatty acid on the turkey body.

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Section: Resultsmentioning

confidence: 99%

Does supplemental zeolite (clinoptilolite) affect growth performance, meat texture, oxidative stress and production of polyunsaturated fatty acid of Turkey poults?

et al. 2018

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“…Although natural nanosized clinoptilolite and/or metformin did not affect pronouncedly the levels of serum glucose, minerals, and lipid profile in rats with high-fat-diet/STZ induced diabetes, the co-treatment of clinoptilolite with the drug notably increased high-density lipoprotein (HDL) cholesterol, while Cu and Ca levels increased only in the metformin group [201]. In STZ induced diabetic rats treated with nanosized clinoptilolite, blood glucose was found to decrease to near normal levels (12.4 vs. 27.5 mmol/L), but no significant impact on oxidative stress markers was estimated [202]. Nanosized clinoptilolite injected to STZ induced diabetic rats caused a partial improvement in their weight status and lack of undesirable effects, although beneficial changes in lipid profile were not detected, which could be connected with short study duration [203].…”

Section: Other Functional Applications Of Human Supplementsmentioning

confidence: 99%

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

2019

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Dietary supplements and foods for special medical purposes are special medical products classified according to the legal basis. They are regulated, for example, by the European Food Safety Authority and the U.S. Food and Drug Administration, as well as by various national regulations issued most frequently by the Ministry of Health and/or the Ministry of Agriculture of particular countries around the world. They constitute a concentrated source of vitamins, minerals, polyunsaturated fatty acids and antioxidants or other compounds with a nutritional or physiological effect contained in the food/feed, alone or in combination, intended for direct consumption in small measured amounts. As nanotechnology provides “a new dimension” accompanied with new or modified properties conferred to many current materials, it is widely used for the production of a new generation of drug formulations, and it is also used in the food industry and even in various types of nutritional supplements. These nanoformulations of supplements are being prepared especially with the purpose to improve bioavailability, protect active ingredients against degradation, or reduce side effects. This contribution comprehensively summarizes the current state of the research focused on nanoformulated human and veterinary dietary supplements, nutraceuticals, and functional foods for special medical purposes, their particular applications in various food products and drinks as well as the most important related guidelines, regulations and directives.

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“…Several studies have been conducted on using the cold plasma in diabetes mellitus complications treatment, directly, such as wound healing in case of diabetic rats, and indirectly such as nano-sized clinoptilolite production by the cold plasma, and its effect on reducing hyperglycemia in rats 2,5,23 . Also, in recently promising study has been reported after diabetic wound treatment by the cold plasma, the levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) elevated, and the result of CAP on wound healing revealed the plasma role in upregulating cytokines secretion (as an important part of inflammatory system) such as IL-1, and IL-6 5,24 .…”

Section: Introductionmentioning

confidence: 99%

The effect of cold atmospheric plasma on diabetes-induced enzyme glycation, oxidative stress, and inflammation; in vitro and in vivo

Rezaeinezhad

Eslami

Mirmiranpour

et al. 2019

Sci Rep

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Cold atmospheric plasma (CAP) is known as the versatile tool in different biological, and medical applications. In this study, we investigated the effect of cold plasma on diabetes via in vitro and in vivo assessments. We performed the in vitro assay to evaluate the impact of CAP on glycated glutathione peroxidase (GPx) through enzyme activity measurement as a function index and far- and near-UV circular dichroism (CD) and fluorescence analysis as structure indices. The result of in vitro assessment showed that the exposure of glycated GPx to plasma causes a considerable increase in enzyme activity up to 30%. Also, the evaluation of far- and near-UV CD and fluorescence analysis indicated a modification in the protein structure. According to obtained result from in vitro assessment, in vivo assay evaluated the effect of CAP on diabetic mice through analyzing of blood glucose level (BGL), advanced glycation end products (AGEs), antioxidant activity, oxidative stress biomarkers such as malondialdehyde (MDA), advanced oxidation protein products (AOPP), and oxidized low-density lipoprotein (oxLDL), and inflammation factors including tumor necrosis factor (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6). The result of in vivo experiment also showed a 20% increase in antioxidant activity. Also, the reduction in AGEs, oxidative stress biomarkers, and inflammatory cytokines concentrations was observed. The result of this study revealed that CAP could be useful in diabetes treatment and can be utilized as a complementary method for diabetes therapy.

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The Effects of Natural Clinoptilolite and Nano-Sized Clinoptilolite Supplementation on Glucose Levels and Oxidative Stress in Rats With Type 1 Diabetes

Abstract: Nano-sized clinoptilolite exerted a hypoglycemic effect in streptozotocin-induced diabetic rats but had no significant influence on oxidative stress markers.

Cited by 20 publications

References 44 publications

Does supplemental zeolite (clinoptilolite) affect growth performance, meat texture, oxidative stress and production of polyunsaturated fatty acid of Turkey poults?

Does supplemental zeolite (clinoptilolite) affect growth performance, meat texture, oxidative stress and production of polyunsaturated fatty acid of Turkey poults?

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

The effect of cold atmospheric plasma on diabetes-induced enzyme glycation, oxidative stress, and inflammation; in vitro and in vivo

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