The effects of moderate-, strenuous- and over-training on oxidative stress markers, DNA repair, and memory, in rat brain

Effect of high intensity interval training on 8-oxoguanine DNA glycosylase and 8-hydroxy-2-deoxyguanosine contents in the brain and liver of rats

“…In addition, it seems that observed changes in OGG1 and 8-OHdG are simply due to HIIT protocol. While two previous studies have been reported that running (Koltai et al, 2011) and swimming (Ogonovszky et al, 2005b) with low to moderate intensity have no significant influence on OGG1 and 8-OHdG levels in rat's hippocampus, our findings show an increase in OGG1 contents of brain and liver following HIIT. Our findings are supported by a study by Ogonovszky et al (2005), who reported an increase in OGG1 activity and 8-OHdG levels of rat liver following strenuous and overtraining (Ogonovszky et al, 2005a).…”

“…ROS generates by different sources in the cells including: mitochondrial electron transport chain, NADPH oxidase and xanthine oxidize (Ogonovszky et al, 2005a(Ogonovszky et al, , 2005b. Although, ROS at low doses plays an important role at physiological processes (Radak et al, 2008), but ROS at large concentrations can modify oxidized lipids, proteins and DNA (Urso et al, 2003, Radak et al, 2008.…”

“…Although, ROS at low doses plays an important role at physiological processes (Radak et al, 2008), but ROS at large concentrations can modify oxidized lipids, proteins and DNA (Urso et al, 2003, Radak et al, 2008. Hence, cells are equipped with antioxidant and repairing enzymes to overcome stress oxidative conditions (Ogonovszky et al, 2005a(Ogonovszky et al, , 2005b. OGG1, as main repair enzyme, expresses in all kinds of tissues with significantly different levels, recognizes and cleaves 8-OHdG from DNA (Ogonovszky et al, 2005a).…”

“…Mild electric shock (0.5 mA, 1 HZ) and soft sponge were used to stimulate the animals to run . The rats of the C group were exposed to the same environment as HIIT groups without running (Ogonovszky et al, 2005b).…”

“…However, it appears that exercise, especially intensive exercise training, has potential to increase production of reactive oxygen species (ROS) through increases in oxygen consumption (Ogonovszky et al, 2005a(Ogonovszky et al, , 2005b. This occurrence subsequently yields serious damage oxidation of proteins, lipids and genomic structures (Radak et al, 2006, 2008, Nikolaidis et al, 2009.…”