The effects of Mannheimia haemolytica and albendazole on marbofloxacin pharmacokinetics in lambs

Altan, Feray; İpek, Duygu Neval Sayın; Çorum, Orhan; Yesilmen, Simten; İpek, Polat; Üney, Kamil

doi:10.1007/s11250-019-01980-5

Cited by 2 publications

(2 citation statements)

References 44 publications

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“…These findings are consistent with other studies that reported a reduced ClT/F of danofloxacin, marbofloxacin, and tilmicosin in respiratory infections [69][70][71][72]. However, the ClT/F of marbofloxacin increased in lambs naturally infected with M. haemolytica [73]. The ClT of drugs is influenced by a variety of factors, particularly the blood flow to the excretion organs, the binding ratio of the drug to plasma proteins, and the activity of drug-metabolizing enzymes.…”

Section: Pharmacokinetics Of Danofloxacinsupporting

confidence: 91%

Pharmacokinetic Behavior and Pharmacokinetic/Pharmacodynamic Integration of Danofloxacin Following Single or Co-Administration with Meloxicam in Healthy Lambs and Lambs with Respiratory Infections

Ural

Üney

2021

Antibiotics

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The aim of this study was to determine the pharmacokinetics and pharmacodynamics of danofloxacin (DAN; 6 mg/kg) following subcutaneous administration alone or co-administration with meloxicam (MLX; 1 mg/kg) in healthy lambs and lambs with respiratory infections. The study was carried out using a total of four groups: HD (healthy; n = 6) and ID (infected; n = 7) groups who were administered DAN only, and HDM (healthy; n = 6) and IDM (infected; n = 7) groups who were administered DAN and MLX simultaneously. The plasma concentrations of DAN were determined using high-performance liquid chromatography–UV and analyzed by the non-compartmental method. DAN exhibited a similar elimination half-life in all groups, including both the healthy and infected lambs. The total clearance in the HDM, ID and IDM groups and volume of distribution in the HDM and IDM groups were significantly reduced. MLX in the IDM group significantly increased the area under the curve (AUC) and peak concentration (Cmax) of DAN compared to the HD group. The Mannheimia haemolytica, Escherichia coli, and Streptococcus spp. strains were isolated from bronchoalveolar lavage fluid samples of the infected lambs. When co-administration with meloxicam, DAN at a 6 mg/kg dose can provide optimum values of ƒAUC0–24/MIC (>56 h) and ƒCmax/MIC (>8) for susceptible M. haemolytica isolates with an MIC90 value of 0.25 µg/mL and susceptible E. coli isolates with an MIC value of ≤0.125 µg/mL.

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Section: Pharmacokinetics Of Danofloxacinsupporting

confidence: 91%

Pharmacokinetic Behavior and Pharmacokinetic/Pharmacodynamic Integration of Danofloxacin Following Single or Co-Administration with Meloxicam in Healthy Lambs and Lambs with Respiratory Infections

Ural

Üney

2021

Antibiotics

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“…Fluoroquinolones inhibit the synthesis of bacterial DNA by binding to DNA gyrase or topoisomerase, thereby producing an antibacterial effect against gram-negative and grampositive bacteria (Rusch et al, 2017). Marbofloxacin (MBF) is a class of FQ that has been commonly used in the treatment of various microbial infections in animals (Balikci et al, 2008;Hoeltig et al, 2018;Altan et al, 2019;Dokuzeylül et al, 2019). However, the abuse of FQ, including MBF, has left residue in animalderived food samples, such as milk.…”

Section: Introductionmentioning

confidence: 99%

Sensitive immunoassays based on a monoclonal antibody for detection of marbofloxacin in milk

Luo

Xing

Guo³

et al. 2020

Journal of Dairy Science

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Marbofloxacin (MBF) is a key class of synthetic fluoroquinolone antibiotic that is commonly used as a veterinary drug. However, excess residue of MBF in animal-derived food samples, such as milk, is harmful to consumers. In this study, 4 mAb against MBF, namely, M4E3, M7A6, M3C7, and M5C6, were produced. Indirect competitive (ic) ELISA revealed that the M4E3 exhibited the highest sensitivity with a half-maximal inhibitory concentration (IC 50 ) of 0.07 ng/mL and a limit of detection of 0.01 ng/mL for detection of MBF.The results of the cross-reactivity experiment revealed that the M4E3 could detect lomefloxacin, ofloxacin, fleroxacin, pefloxacin, danofloxacin, and enrofloxacin sensitively with IC 50 of 0.02, 0.07, 0.18, 0.27, 0.30, and 0.32 ng/mL, respectively. Meanwhile, a cross-reactivity experiment showed that the M4E3 had a crossover rate of more than 20% with these fluoroquinolone analogs. A weak crossover rate below 1.11% was observed with 14 other fluoroquinolone analogs. The recovery rate of MBF in milk ranged from 72.28% to 129.19%, which showed that the developed indirect competitive ELISA was effective in detecting MBF in milk. Furthermore, a visual colloidal gold-based immunochromatographic assay was developed for detecting MBF with a cut-off value of 1 ng/mL in both phosphate-buffered saline and a milk sample by using this mAb. Given this sensitive mAb, both indirect competitive ELISA and colloidal gold-based immunochromatographic assay could be effective screening tools for detection of MBF in milk.

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The effects of Mannheimia haemolytica and albendazole on marbofloxacin pharmacokinetics in lambs

Cited by 2 publications

References 44 publications

Pharmacokinetic Behavior and Pharmacokinetic/Pharmacodynamic Integration of Danofloxacin Following Single or Co-Administration with Meloxicam in Healthy Lambs and Lambs with Respiratory Infections

Pharmacokinetic Behavior and Pharmacokinetic/Pharmacodynamic Integration of Danofloxacin Following Single or Co-Administration with Meloxicam in Healthy Lambs and Lambs with Respiratory Infections

Sensitive immunoassays based on a monoclonal antibody for detection of marbofloxacin in milk

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