This study was carried out to investigate the effect of thyroidectomy on the histology of rat sublingual gland. Twenty-eight male Wistar albino rats, aged 4 weeks and weighing between 45-55 g, were used. The rats were divided into two experimental groups (control and thyroidectomy), each containing 14 animals. Total thyroidectomy of rats was performed under ether anesthesia in thyroidectomy group. The rats in the control group were sham operated without having the thyroidectomy. Seven rats randomly selected from both groups were fixed using the perfusion fixation technique 2 and 6 weeks after thyroidectomy, and their sublingual glands were harvested for histological investigation. No histological difference was observed between the two groups 2 weeks after thyroidectomy. However, 6 weeks after thyroidectomy considerable cytoplasmic vacuolization of the epithelial cells of the mucous tubules was seen in the thyroidectomy group compared to the controls. Enlargement of mucous tubules was also observed, and the lumina in most of the tubules was quite dilated. In the stroma surrounding the parenchymal tissues, increased lipid tissue mass was observed. In addition, increased connective tissue mass and mononuclear cell infiltrations were evident. Furthermore, the number of mast cells was significantly higher in the thyroidectomy group than in the controls 6 weeks after thyroidectomy. It was concluded that the thyroid gland and hormones might have an influence on the histology of the sublingual gland.

The aim of this study was to determine the pharmacokinetics and pharmacodynamics of danofloxacin (DAN; 6 mg/kg) following subcutaneous administration alone or co-administration with meloxicam (MLX; 1 mg/kg) in healthy lambs and lambs with respiratory infections. The study was carried out using a total of four groups: HD (healthy; n = 6) and ID (infected; n = 7) groups who were administered DAN only, and HDM (healthy; n = 6) and IDM (infected; n = 7) groups who were administered DAN and MLX simultaneously. The plasma concentrations of DAN were determined using high-performance liquid chromatography–UV and analyzed by the non-compartmental method. DAN exhibited a similar elimination half-life in all groups, including both the healthy and infected lambs. The total clearance in the HDM, ID and IDM groups and volume of distribution in the HDM and IDM groups were significantly reduced. MLX in the IDM group significantly increased the area under the curve (AUC) and peak concentration (Cmax) of DAN compared to the HD group. The Mannheimia haemolytica, Escherichia coli, and Streptococcus spp. strains were isolated from bronchoalveolar lavage fluid samples of the infected lambs. When co-administration with meloxicam, DAN at a 6 mg/kg dose can provide optimum values of ƒAUC0–24/MIC (>56 h) and ƒCmax/MIC (>8) for susceptible M. haemolytica isolates with an MIC90 value of 0.25 µg/mL and susceptible E. coli isolates with an MIC value of ≤0.125 µg/mL.

This study provides insight into the development and validation of the simple, rapid and sensitive method of Liquid Chromatography-Tandem Mass Spectrometry for determining the residues of dexamethasone in bovine milk. The maximum residue limit for dexamethasone in bovine milk is 0.3 ng/ml−1. Chromatographic separation was achieved on an Agilent Proshell 120 SB:C18 (2.7µm 100x3.0 mm) column. The bovine milk was extracted with ethyl acetate, and the evaporated elution was dissolved with hexane, water and methanol, and analyzed by the LC-MS/MS method. The mobile phase A was a solution of 5 Mm ammonium formate in water, while the mobile phase B was 0.1% formic acid in acetonitrile. The calibration graphics were prepared within the range of 0.15–0.6 ng/ml−1, and a successful linearity was achieved (r ≥0.999). The limit of detection was 0.016 ng/ml−1. The decision limit (CCα) and detection capability (CCβ) were 0.34 and 0.38 ng/ml−1, respectively.

Mehmet Ural ile İlhan Tekeli Üzerine: "İlhan Hoca dediğiniz an, aklınıza her zaman dünya çapında bir iddia ortaya koymak gelir." İlhan Bey'le tanışıklığınız ne zamana dayanıyor? Yollarınız nasıl birleşti, nasıl devam etti bize özetlerseniz, anlatırsanız seviniriz. İlhan Hoca'nın çalışmalarını yakından izliyor, konferanslarına fırsat bulduğum her zaman katılıyordum. Ama İlhan Hoca'yla yakın çalışma fırsatım, TÜSES (Türkiye Sosyal Ekonomik Siyasal Araştırmalar Vakfı) başkanı olduğum döneme, 2004 yılına rastlar. TÜSES, Erdal İnönü'nün önderliğinde kurulmuş olan bir sosyal demokrat düşünce kuruluşudur. TÜSES olarak 2004 yılında sosyal demokrat vakıflar ve derneklerle birlikte, "Türkiye'de siyaset kültürünü ve pratiğini değiştirmek" konusunda bir çalışma yapmaya karar verdik. Bu kadar iddialı bir çalışmayı ancak İlhan Tekeli'nin düşünsel önderliğinde yapabilirdik. Bu proje aşağı yukarı iki yıl sürdü. Çok sayıda atölye çalışmaları yaptık, konferanslar düzenledik: Bugün maalesef aramızda olmayan, Erdal İnönü, Atilla Karaosmanoğlu gibi çok değerli katılımcılar, çok sayıda bilim insanı, araştırmacı isimler bu çalışmamıza katıldılar, önemli katkılar yaptılar. Biz bu çalışmayı daha sonra TÜSES yayını haline de getirdik. 2007 yılında ise İlhan Tekeli hocamıza, sosyal demokrasiye teori ve uygulamalı alanlardaki katkılarından ötürü, adına bir konferans düzenleyerek TÜSES'in Üstün Hizmet Ödülü'nü takdim ettik. Daha sonra da İlhan Hoca ile TÜSES'in çalışmalarında yine beraber olduk. 2008 sonunda, 2009'da yapılacak yerel seçimler öncesinde İzmir Büyük Şehir Belediye Başkanı (İBB) Aziz Kocaoğlu beni kampanyasında danışmanlık yapmak üzere İzmir'e davet etti. Kampanya çalışmalarında gördüğüm en büyük boşluk, İzmir için yeni bir vizyon eksikliğiydi. Aziz Kocaoğlu başkanlığı döneminde İzmir'i gelecekte nereye taşımak istiyor, nasıl bir İzmir vadediyordu? Bir vizyon geliştirmeniz gerektiğinde, bu yolculuğu beraber yapabileceğiniz tek isim İlhan Tekeli hocadır. Ben derhal İlhan Hoca'yı aradım.

Respiratory tract infections, which are common in sheep farming, involve interactions between the host's immune system, pathogenic microorganisms such as viruses, bacteria, parasites and environmental conditions. Respiratory diseases can affect sheep of any age and breed. However, acute bacterial and viral pneumonia is most common in those aged three to twelve months due to decreased maternal antibody titers. Although lower respiratory tract infections initially started as a condition caused by a single agent, many cases progress to a complex disease involving both bacterial and viral components, making the diagnosis of the disease complicated by the emergence of secondary infections. Although the inflammatory reaction that occurs in respiratory infections is part of the normal healing process, an extreme reaction can impair healing and severely damage the airways. It is optimal to limit the inflammatory reaction by removing the harmful agent, isolating the damaged tissue, and controlling this tissue. In cases of death due to acute pneumonia, antibiotic drugs are used to prevent further deaths and to treat the herd. It has been found that NSAIDs reduce the release of toxic peroxide which causes the proliferation of fibroblasts and the deposition of collagen in inflammatory processes associated with the respiratory tract. It had been reported that clinical findings improve more rapidly when NSAIDs (non-steroidal anti-inflammatory drugs) were used together with antibiotics in respiratory system infections. In this review, the importance of using NSAIDs in the respiratory tract infections of sheep has been mentioned.

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