The effects of magnesium supplementation on abnormal uterine bleeding, alopecia, quality of life, and acne in women with polycystic ovary syndrome: a randomized clinical trial

Abstract

Background Abnormal uterine bleeding (AUB), alopecia, low quality of life, and acne are considered as complications of polycystic ovary syndrome (PCOS). We hypothesized that magnesium supplementation would yield beneficial effects on PCOS related complications. Objective To examine the effects of magnesium supplementation on AUB, alopecia, quality of life, and acne. Methods In this parallel randomized clinical trial, we randomly assigned 64 women with PCOS to the magnesium group (n = 32) or placebo group (n = 32) for 10 weeks. AUB, alopecia, quality of life, and acne were assessed by the International Federation of Gynecology and Obstetrics criterion, the Sinclair Scale, the Health Survey Quality of Life Questionnaire, and the Global Acne Grading System, respectively. This randomized clinical trial was registered at IRCT.ir (IRCT20130903014551N9). Results Magnesium supplementation significantly improved the components of quality of life including physical functioning (p = 0.011), role limitations due to physical health (p = 0.012), role limitations due to emotional problems (p < 0.001), energy/fatigue (p = 0.005), emotional wellbeing (p < 0.001), social functioning (p = 0.002), general health (p = 0.013), and total quality of life (p < 0.001), compared with placebo. No significant effect was observed on acne, alopecia, and AUB. Conclusion Magnesium supplementation in women with PCOS had a significant positive effect on improving total quality of life. Trial registration This randomized clinical trial was registered at IRCT.ir on 2020–10-18 (Registration Code: IRCT20130903014551N9).

The potential effects of magnesium, chromium, vitamin C, and metformin on inflammatory, hormonal, and metabolic factors of women with polycystic ovary syndrome (PCOS)

“…While the etiology of PCOS remains unclear, lifestyle adjustments and nutritional interventions have shown promise in treatment [14]. Emerging evidence supports the bene ts of dietary components like vitamin C (as antioxidants), minerals such as magnesium or chromium, and metformin in standalone administration for PCOS-positive cases, playing a signi cant role in improving metabolic and hormonal disorders, in ammation, and infertility [15][16][17][18][19][20][21][22].…”

“…While the etiology of PCOS remains unclear, lifestyle adjustments and nutritional interventions have shown promise in treatment [14]. Emerging evidence supports the bene ts of dietary components like vitamin C (as antioxidants), minerals such as magnesium or chromium, and metformin in standalone administration for PCOS-positive cases, playing a signi cant role in improving metabolic and hormonal disorders, in ammation, and infertility [15][16][17][18][19][20][21][22].In our present study, targeting treatment-resistant PCOS, our hypothesis was based on the concurrent use of sustained-release vitamin C with citrus bio avonoids, magnesium, and metformin. This combination aimed to enhance sugar and fat metabolism, regulate hormonal systems, and stimulate oogenesis.…”

Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health

“…signifies 'Not Available', which is used to indicate that specific information or data sought in the context of the study could not be obtained or was not accessible at the time of the research. 3 mg [405,406] Daily intake in studies 40 mg [407]-50 mg [72,408,409] 60 mg [102] 100 mg [410]-250 mg [410,411] 70 µg [412] 1000 mg [413,414] 250 mg [409,415] 60 µg [416] 1 mg [102] 3 mg…”