Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo‐controlled clinical trial

Abstract

Background and Aims Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders in women, which causes numerous symptoms in women. The relationship of many micronutrients with this syndrome has been investigated. This study was conducted to examine the effects of magnesium supplementation on hyperandrogenism, hirsutism, and sleep quality in women with PCOS. Methods In this parallel randomized clinical trial, 64 women with PCOS were randomly assigned to the magnesium group ( n = 32) or placebo group ( n = 32) for 10 weeks. Patients in the magnesium group received one 250 mg magnesium oxide tablet, per day. Hyperandrogenism, hirsutism, and sleep quality were measured at the beginning and end of the study. This randomized clinical trial was registered at https://www.IRCT.ir (IRCT20130903014551N8). Results Magnesium supplementation had no significant effect on hyperandrogenism ( p = 0.51 for dehydroepiandrosterone sulfates, p = 0.27 for testosterone), hirsutism ( p = 0.23), and sleep quality ( p = 0.85) compared with placebo. Conclusions The present study showed that a single dose of magnesium supplementation elicited no beneficial effects on the mentioned symptoms in polycystic women. It is possible that the positive effects of magnesium observed in the former studies were due to the synergistic effects of other vitamins or minerals. More studies are needed in this area.

Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health

“…Magnesium serves as a central cofactor in estrogenic metabolic pathways [389] and in glucose homeostasis [390], which is particularly important in people with polycystic ovary syndrome (PCOS) [391]. Hypomagnesemia can increase oxidative stress and impair oocyte viability [392] and endometrial functionality [183].…”

Beyond Counting Sheep: Exploring the Link between Polycystic Ovary Syndrome and Sleep Health

“…Several studies have explored using other lifestyle-related approaches to improve the sleep quality and/or quantity of women with PCOS, including physical activity, 138 behavioral modification, 139 dietary intake, 140 and psychosocial wellbeing. 141 Other studies have also explored pharmacological approaches such as magnesium, 142 melatonin, 143 and metformin supplementation. 144 Recently, Oberg and colleagues in a randomized controlled trial compared sleep health variables assessed by actigraphy in women with PCOS (overweight/obese) with controls and also assessed sleep variables after a 4-month behavioral modification intervention (using goal setting, problem solving, stress management, stimulus control, and techniques for avoiding instant gratification to target diet and physical activity and achieve long-term weight control) in comparison with minimal intervention.…”