The effects of intra-rectal and intra-peritoneal application of Origanum onites L. essential oil on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat

Dündar, Emine; Olgun, Esra Gurlek; Işıksoy, Serap; Kürkçüoğlu, Mine; Başer, K. H. C.; Bal, Cengiz

doi:10.1016/j.etp.2007.11.009

Cited by 56 publications

(38 citation statements)

References 33 publications

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“…17,19,40,41 It is also well known that essential oils which are rich in carvacrol possess strong antioxidant properties equivalent to those of ascorbic acid, butyl hydroxyl toluene and vitamin E. 42 In the present study OOEO ameliorated the side effects of cisplatin by inhibiting lipid peroxidation. Contrary to our expectations, the use of OOEO with GSE did not have a synergical antioxidant effect on cisplatin-induced oxidative stress.…”

Section: Discussionmentioning

confidence: 73%

Effects of Grape seed Extract and Origanum Onites Essential Oil on Cisplatin-Induced Hepatotoxicity in Rats

Çetin¹,

Arslanbaş²,

Saraymen³

et al. 2011

UHOD

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Cisplatin is a widely used anticancer drug but, it can produce undesirable effects such as hepatotoxicity even in therapeutic doses. The underlying mechanism in hepatotoxicity has been attributed to free oxygen radicals. The present study was designed to determine the possible protective effects of grape seed extract (GSE) and Origanum onites essential oil (OOEO) on liver toxicity induced by cisplatin. Ninetysix-male Wistar albino rats were divided into eight groups, twelve in each (Control, GSE, OOEO, GSE+OOEO, Cisplatin, GSE+ Cisplatin, OOEO+ Cisplatin, GSE+OOEO+ Cisplatin) and followed up for 10 days. Cisplatin and OOEO were injected intraperitoneally. GSE was administered with gavage. The histopathological examination of liver tissues was performed by light microscope. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) levels were determined in liver tissues. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured in serum. Cisplatin-induced considerable hepatocyte damage under microscopic examination, and an increase in MDA levels as well as a decrease in the activities of antioxidant enzymes, including SOD, GSH-Px in liver tissues and an increase in serum ALT and AST (p< 0.001). The addition of GSE and/or OOEO significantly prevented microscopic tissue damage, reversed oxidative stress parameters and biochemical values compared to the cisplatin group (p< 0.001). In conclusion GSE and OOEO may be used in adjuvant therapy to prevent cisplatin-induced hepatotoxicity, but further studies using various doses, different time intervals, and a larger number of animals need to be carried out.Keywords: Cisplatin, Hepatotoxicity, Free Radicals, Grape, Thyme ÖZET Sisplatin, kanser tedavisinde yayg›n olarak kullan›lan fakat tedavi dozlar›nda dahi karaci¤er hasar› gibi istenmeyen yan etkilere sebep olabilen bir ilaçt›r. Sisplatinin karaci¤er dokusunda yapt›¤› hasar›n alt›nda yatan mekanizma büyük oranda serbest oksijen radikallerine ba¤l›d›r. Bu çal›flmada s›çanlarda sisplatin tedavisine ba¤l› oluflan karaci¤er hasar›nda üzüm çekirde¤i özütünün (ÜÇÖ) ve esansiyel kekik ya¤›n›n (EKY) muhtemel koruyucu etkilerinin araflt›r›lmas› amaçlanm›flt›r. Doksanalt› adet Wistar albino cinsi erkek s›çan; her biri oniki hayvandan oluflan sekiz gruba bölünerek (Kontrol, ÜÇÖ, EKY, ÜÇÖ+EKY, Sisplatin, ÜÇÖ+Sisplatin, EKY+Sisplatin, ÜÇÖ+EKY+Sisplatin), on gün süreyle takip edildi.

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Section: Discussionmentioning

confidence: 73%

Effects of Grape seed Extract and Origanum Onites Essential Oil on Cisplatin-Induced Hepatotoxicity in Rats

Çetin¹,

Arslanbaş²,

Saraymen³

et al. 2011

UHOD

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“…In recent years, a large number of investigations have been performed on the antimicrobial activities of essential oils (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). Antimicrobial evaluations of essential oils are difficult because of their volatility, insolubility in water, and because of their complex chemical compounds.…”

Section: Resultsmentioning

confidence: 99%

“…Even though carvacrol is the major compound of this oil, carvacrol showed less activity than O onites oil. This result suggests that essential oils might have some synergistic affects within their components (29)(30)(31). It is not just the major compound itself which is important for antibacterial property several compounds working in synergy are important in essential oils.…”

Section: Rri Compound a (%) B (%) C (%) D (%) E (%) F (%) G (%) H (%)mentioning

confidence: 90%

“…Turkey is located on the crossroads of three different floristic regions (namely Europe-Siberia, Iran-Turan, Mediterranean). The flora of Turkey is made up of 10000 species from 173 families and 1225 genera, 3000 endemic species, and sixteen endemic genera (25)(26)(27)(28)(29)(30)(31)(32)(33). In this study, essential oils extracted from ten plant species were examined for the control and prevention of AFB disease antibacterial activities.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of some essential oils as alternative antibiotics against American foulbrood agentPaenibacillus larvaeon honey beesApis melliferaL

Özkırım

Keskin

Kürkçüoğlu

et al. 2012

Journal of Essential Oil Research

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“…alternative medicine (CAM) such as homeopathy, herbal medication and vitamin therapy for treatment (10). Experimental information acquired from animal models of colitis suggested the useful effects of the plant extracts such as Teucrium polium (11), Calendula officinalis (8), Agave Americana Linn (12), Carum carvi (13), Naringenin (14), and Pterocarpus marsupium (15) on improving UC.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Effect of Melillotus officinalis L. Aqueous Extracts on Healing of Acetic Acid-Induced Ulcerative Colitis in Male Rats

Tanideh¹,

Bahrani²,

Khoshnood-Mansoorkhani³

et al. 2016

Ann Colorectal Res

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The effects of intra-rectal and intra-peritoneal application of Origanum onites L. essential oil on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat

Cited by 56 publications

References 33 publications

Effects of Grape seed Extract and Origanum Onites Essential Oil on Cisplatin-Induced Hepatotoxicity in Rats

Effects of Grape seed Extract and Origanum Onites Essential Oil on Cisplatin-Induced Hepatotoxicity in Rats

Evaluation of some essential oils as alternative antibiotics against American foulbrood agentPaenibacillus larvaeon honey beesApis melliferaL

Evaluating the Effect of Melillotus officinalis L. Aqueous Extracts on Healing of Acetic Acid-Induced Ulcerative Colitis in Male Rats

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