The Effects of Interferon α2b on Chemically-Induced Peritoneal Fibrosis and on Peritoneal Tissue MMP-2 and TIMP-2 Levels in Rats

Uçar, Elif Yılmazel; Borazan, Ali; Semerci, Ersan; Dn, Binici; Yaldız, Mehmet; Aysal, Anıl; Altuğ, Enes; Kuvandik, Ceren; Hüzmelí, Can; Yetim, Tülin Durgun; Canda, Şerefettin

doi:10.1177/147323001003800121

Cited by 6 publications

(8 citation statements)

References 16 publications

(26 reference statements)

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“…MMPs may play an important role in the development of peritoneal fibrosis via angiogenesis and cell infiltration. Moreover, studies support the view that the family of MMPs, especially MMP-2, is released mainly from fibroblasts, epithelial cells and macrophages and they play an important role in peritoneal fibrosis in animal models and patients with EPS [7,[10][11][12].…”

Section: Introductionmentioning

confidence: 76%

“…The increased activity of gelatinases, especially MMP-2, plays a major role in the development of inflammation and fibrosis in EPS models. In peritoneal tissues MMP-2 is present in both the pro-MMP-2 and active MMP-2 forms [12]. MMP-2 is expressed in endothelial cells that compose microvasculature for angiogenesis and in activated mesothelial cells.…”

Section: Infusion Of Bradykininmentioning

confidence: 99%

“…BK receptors, B1 (B1R) and B2 (B2R), have been defined based on their pharmacological properties [16]. The B2R is constitutively expressed at the vascular level, and it is also expressed on neutrophils [12]. B2R appears to be the principal kinin receptor under physiological conditions and at the acute stage of the inflammatory response.…”

Section: Infusion Of Bradykininmentioning

confidence: 99%

“…The evaluation of staining intensity, respectively negative (0), weak (1), mild (2), severe (3) were scored. When making an assessment flat and cubic mesothelial cells, fibroblasts submesothelial compact zone, the surface of endothelial cells and monocytes/macrophages staining intensities were compared [10,12,27].…”

Section: Histological Observationsmentioning

confidence: 99%

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The Effects of Systemic Infusion of Bradykinin on Experimental Peritoneal Fibrosis

Yaşar¹,

Uysal²,

Öztop³

et al. 2015

Osmangazi̇ Journal of Medicine

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Background. Bradykinin (BK) is a proinflammatory peptide that is involved in the inflammation and vascular regulation. Recent studies have indicated that stimulation of BK-B2 receptors may attenuate fibrosis in renal and liver injuries and it is also expressed on neutrophils.Objectives. The aim of this study is to investigate the expression of bradykinin-B2 receptors and to explore the effects of systemic infusion of bradykinin (BK) using histochemical and immunohistochemical methods in a rodent model of chlorhexidine gluconate-induced peritoneal fibrosis.Materials and Methods. In this experimental study, twenty-four male SpragueDawley rats (n=24) were divided into three groups; Control, Chlorhexidine Gluconate (CG) and Chlorhexidine Gluconate+Bradykinin treatment (CG+BK). All animals were euthanized at day 21 and peritoneal tissue samples were taken under anesthesia induced by 50 mg/kg s.c. sodium pentothal. Histological assessments were then performed using hematoxylin and eosin, Periodic Acid-Schiff staining; and antibodies against TGF-β1, MMP-2, PAI-1 and bradykinin-B2 (BK-B2) receptors.Results. Thickness of submesothelial layer, neovascularization, polimorphonuclear granulocytes and fibrosis increased in the CG+BK treatment group. While expression of TGF-β1, MMP-2 and PAI-1 was not significantly different than that of the CG group. Staining of BK-B2 receptors was up-regulated in the submesothelial compact zone of the CG+BK treatment group.Conclusions. The results of our study showed that the stimulation of BK-B2 receptors by systemic BK perfusion did not have any antifibrotic effects in the encapsulating peritoneal sclerosis rat models, and actually, it may even promote fibrosis by aggravating inflammation.

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Section: Introductionmentioning

confidence: 76%

Section: Infusion Of Bradykininmentioning

confidence: 99%

Section: Infusion Of Bradykininmentioning

confidence: 99%

Section: Histological Observationsmentioning

confidence: 99%

See 2 more Smart Citations

The Effects of Systemic Infusion of Bradykinin on Experimental Peritoneal Fibrosis

Yaşar¹,

Uysal²,

Öztop³

et al. 2015

Osmangazi̇ Journal of Medicine

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“…Mūsdienās ir aktuāli pētījumi par matrices metaloproteināžu un to audu inhibitoru nozīmi saaugumu gadījumā, jo balanss starp šiem enzīmiem nodrošina ekstracelulārās matrices veidošanos un degradāciju (Ucar et al, 2010). Matrices metaloproteināze-2 (MMP-2)…”

Section: Darbā Lietotie Saīsinājumiunclassified

Intraabdominālu saaugumu veidošanās un norises kompleksie morfopatoģenētiskie aspekti bērniem līdz gada vecumam. Promocijas darbs

Junga¹

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ANOTĀCIJAIntraabdomināli saaugumi ir fibrozi savienojumi starp vēdera dobuma orgāniem un/vai vēdera dobuma orgāniem un vēdera dobuma sienu. Tie var būt iegūti vai iedzimti. Iegūtus saaugumus galvenokārt iedala iekaisuma izraisītos un postoperatīvos saaugumos. Savukārt iedzimtus saaugumus saista ar vēdera dobuma embrionālās attīstības traucējumiem un/vai pat ar embrioģenēzes ģenētisku defektu. Intraabdomināli saaugumi var būt asimptomātiski, bet tie var būt arī tādas bīstamas komplikācijas kā intestinālas obstrukcijas cēlonis. Intraabdominālu saaugumu morfopatoģenēze ir komplekss process, kurš tiek raksturots ar ekstracelulārās matrices uzkrāšanos, audu hipoksiju un iekaisuma klātbūtni.Pētījuma mērķis bija noteikt un aprakstīt morfopatoģenētiskos faktorus, kas saistīti ar intraabdominālu saaugumu veidošanos un norisi, kā arī aprakstīt to savstarpējo mijiedarbību.Pētījumā tika iekļauti 50 saaugumu audu paraugi no 49 pacientiem ar pilnīgu vai daļēju kuņģa zarnu trakta necaurejamību un astoņu kontroles vēderplēves audu materiāls, kas iegūts, veicot cirkšņa trūces plastiku. Visi audu paraugi tika iegūti no pacientiem vecumā līdz vienam gadam.

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Distribution of Lysosome-Associated Membrane Proteins-1 and -2, and Cathepsin D in Eosinophilic Granular Bodies: Possible Relationship to Cyst Development in Pilocytic Astrocytomas

et al. 2010

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The Effects of Interferon α2b on Chemically-Induced Peritoneal Fibrosis and on Peritoneal Tissue MMP-2 and TIMP-2 Levels in Rats

Abstract: .88 ± 22.1, 9.27 ± 2.03 µm, respectively. Pegylated IFN-a2b decreased CH-induced expression of MMP-2 in the parietal peritoneum, but had no effect on TIMP-2 levels. Further studies are needed to determine the optimal dosage and duration for pegylated IFN-a2b treatment.

Cited by 6 publications

References 16 publications

The Effects of Systemic Infusion of Bradykinin on Experimental Peritoneal Fibrosis

The Effects of Systemic Infusion of Bradykinin on Experimental Peritoneal Fibrosis

Intraabdominālu saaugumu veidošanās un norises kompleksie morfopatoģenētiskie aspekti bērniem līdz gada vecumam. Promocijas darbs

Distribution of Lysosome-Associated Membrane Proteins-1 and -2, and Cathepsin D in Eosinophilic Granular Bodies: Possible Relationship to Cyst Development in Pilocytic Astrocytomas

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