The effects of iloprost on ischemia-reperfusion injury in skeletal muscles in a rodent model

Avci, Tuba; Erer, Dilek; Küçük, Ayşegül; Öztürk, Yasin; Tosun, Murat; Oktar, Gürsel Levent; Arslan, M; İriz, Erkan; Kavutçu, Mustafa; Tatar, Tolga

doi:10.1016/j.jss.2013.09.031

Cited by 11 publications

(14 citation statements)

References 33 publications

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“…Similarly, some other studies also found decreased serum and tissue SOD activities in models of I/R injury. [15,19] In the present study, the serum SOD activity was numerically lower in the I/R and solvent groups, but significantly higher in the edaravone group compared to the I/R group. The SOD activity in the renal tissue was numerically lower in the I/R group than in the control group and numerically higher in the edaravone group than in the I/R group; however, none of these differences were significant.…”

Section: Discussionsupporting

confidence: 39%

Renoprotective effect of edaravone in acute limb ischemia/reperfusion injury

İnce

Akar

Arıcı

2020

Turk Gogus Kalp Dama

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Akut alt ekstremite iskemi-reperfüzyon hasarında edaravonun renal koruyucu etkisi ÖZ Amaç: Bu deneysel çalışmada, sıçan modelinde akut alt ekstremite iskemi/reperfüzyonuna bağlı böbrek hasarında edaravonun etkinliği araştırıldı. Ça lış ma pla nı: Bu çalışmada Haziran 2015-Ağustos 2015 tarihleri arasında toplam 40 erkek Wistar sıçan kullanıldı. Sıçanlar sham, iskemi/reperfüzyon, edaravon ve solvent gruplarına randomize edildi (n=10 her bir grupta). İnfrarenal abdominal aort 120 dk. süreyle klemlendi ve sonrasında klemp kaldırılarak 120 dk. reperfüze edildi. İskemi indüksiyonundan 30 dk. önce edaravon intravenöz olarak verildi. Serum ve böbrek doku örnekleri biyokimyasal ve histopatolojik olarak analiz edildi. Bul gu lar: Edaravon serum ve doku malondialdehit düzeylerini iskemi/reperfüzyon grubunda azalttı. Serum süperoksit dismutaz aktivitesi, iskemi/reperfüzyon ve solvent gruplarına kıyasla, edaravon grubunda anlamlı düzeyde yüksekti. Serum nitrik oksit düzeyi iskemi/reperfüzyon grubunda, sham grubuna kıyasla, rakamsal olarak yüksek bulundu. Edaravon serum nitrik oksit düzeyini düşürdü. Serum nitrik oksit düzeyi edaravon grubunda, solvent grubundan, daha düşük idi. Doku nitrik oksit düzeyi iskemi/reperfüzyon grubunda, sham grubundan, anlamlı düzeyde daha yüksek idi. İskemi/ reperfüzyon grubunda histopatolojik değişikliklerde edaravon ile düzelme görüldü. So nuç: Edaravon alt ekstremite iskemi/reperfüzyonuna bağlı renal hasarı azalttı. Bu nedenle, aort ve periferik damar cerrahisinde akut iskemi/reperfüzyon hasarını hafifletmede kullanılabilir.

show abstract

Section: Discussionsupporting

confidence: 39%

Renoprotective effect of edaravone in acute limb ischemia/reperfusion injury

İnce

Akar

Arıcı

2020

Turk Gogus Kalp Dama

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“…Second, skeletal muscle have longer endurance to IR injury than other susceptible organs. Drugs such as silibinin [24], iloprost [25], and dextran sulfate [26], which can attenuate the heart, renal, and brain IR injury have little effect in skeletal muscle injury. Finally, some drugs like hydrogen sulfide [2] and carbon monoxide [21], which are effective in physiologic dosage might be poisonous in moderate or high doses.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen-rich saline attenuates ischemia–reperfusion injury in skeletal muscle

Huang¹,

Wang²,

Tu³

et al. 2015

Journal of Surgical Research

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“…It is less toxic and expands blood vessels through different mechanisms. It can change the concentration of biomarkeroactive substances in patients with biomarkercular endothelial dysfunction …”

Section: Discussionmentioning

confidence: 99%

“…Iloprost, a vasodilator, is commonly used in treating patients with PAH. It is also a synthetic analogue of prostacyclin with few systemic adverse effects but with the additional advantages such as simple delivery, minimal toxicity, and dilation of the pulmonary artery through different cellular mechanisms …”

Section: Introductionmentioning

confidence: 99%

Effect of iloprost on biomarkers in patients with congenital heart disease‐pulmonary arterial hypertension

Zheng

Long

et al. 2017

Clin Exp Pharma Physio

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SummarySome biomarkers play important roles in the endothelial dysfunction of patients with pulmonary arterial hypertension (PAH), including nitric oxide (NO), endothelin‐1 (ET‐1), asymmetric dimethylarginine (ADMA), galectin‐3 (Gal‐3), B‐type natriuretic peptide (BNP), and uric acid (UA). However, studies on these biomarkers in pulmonary artery blood in congenital heart disease‐PAH (CHD‐PAH) and the effect of iloprost on the regulation of biomarkers are lacking. This study investigated potential CHD‐PAH biomarkers and their association with the severity of disease. The effect of iloprost on the regulation of these biomarkers was also studied. A total of 31 patients with CHD‐PAH were enrolled. Seven with positive effects of iloprost (the average reduction in mPAP 11.13±1.73 mm Hg) and 19 with negative effects of iloprost (the average reduction in mPAP 4.21±4.87 mm Hg; iloprost positive group [IPG] vs iloprost negative group [ING], P<.01) and five age‐matched controls were studied. The pulmonary artery blood sample was collected before and after inhaling iloprost, and the plasma concentrations of Gal‐3, ADMA, ET‐1, and NO were measured. A significant positive linear relationship was observed between mPAP and plasma ET‐1, BNP, ADMA, and UA levels in all patients with CHD‐PAH. ET‐1, ADMA, BNP, and UA levels had a significant linear relationship with mean pulmonary arterial pressure, which could be used to predict the severity of CHD‐PAH. ET‐1 might be a potential biomarker to pre‐evaluate the effect of iloprost on CHD‐PAH. Iloprost could affect the expression of Gal‐3 and, therefore, the process of fibrosis could be influenced by iloprost.

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The effects of iloprost on ischemia-reperfusion injury in skeletal muscles in a rodent model

Cited by 11 publications

References 33 publications

Renoprotective effect of edaravone in acute limb ischemia/reperfusion injury

Renoprotective effect of edaravone in acute limb ischemia/reperfusion injury

Hydrogen-rich saline attenuates ischemia–reperfusion injury in skeletal muscle

Effect of iloprost on biomarkers in patients with congenital heart disease‐pulmonary arterial hypertension

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