The effects of icariin on wound healing of extraction sites with administration of zoledronic and dexamethasone: A rat model study

Liu, Jie; Mattheos, Nikos; Su, Cheng; Deng, Chuanxi; Luo, Nanyu; Wang, Zekun; Tang, Hua

doi:10.1111/jop.12659

Cited by 13 publications

(12 citation statements)

References 26 publications

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“…ROT was given by subcutaneous injection once per day at a dose of 1 mg/kg, and ICA was administrated by oral gavage. The ICA and ROT concentrations were selected according to previous studies [22,28,29]. The control group was subjected to an equivalent volume of vehicles.…”

Section: Methodsmentioning

confidence: 99%

Icariin-mediated activation of autophagy confers protective effect on rotenone induced neurotoxicity in vivo and in vitro

et al. 2019

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Highlights Icariin protects against rotenone-induced neuronal cell injury in vitro and in vivo. Icariin improves mitochondrial respiration in neuronal cells damaged by rotenone Icariin modulates phosphorylation of mTOR. Icariin attenuates accumulation of p62 caused by rotenone. Upregulation of autophagic flux is involved in the protective action of icariin.

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Section: Methodsmentioning

confidence: 99%

Icariin-mediated activation of autophagy confers protective effect on rotenone induced neurotoxicity in vivo and in vitro

et al. 2019

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“…Soft tissue toxicity is one of the hypotheses explaining the pathogenesis of MRONJ and promotive effect on soft tissue healing of icarrin was noted in the present study: the area of the wound in icarrin group was significantly smaller than the untreated group. The stimulative effect of icarrin on wound healing have been confirmed by other studies 13,20,21 and this may correlate to upregulated expression of VEGF which correlates to angiogenesis, 22 activated the MEK/ERK and PI3K/Akt/eNOS‐dependent signal pathways and promoted differention of keratinocyte involved in wound healing 13,20,23 . Angiogenesis is also an important factor in bone healing 12 and studies have shown the promising effect of icarrin on bone healing via promoting angiogenesis 11,24 .…”

Section: Discussionmentioning

confidence: 73%

“…Besides, icariin has shown its promotion of angiogenesis 11 which is also important in bone defect healing 12 . And pharmaceutical effects of icariin on anti‐inflammation, protecting immune system, and promoting soft tissue healing were noted 8,13 . These effects of icariin are all related to the pathophysiology of MRONJ and indicate the potential therapeutic effect on MRONJ.…”

Section: Introductionmentioning

confidence: 99%

Management of medication‐related osteonecrosis of jaw: Comparison between icariin and teriparatide in a rat model

Liu

Mattheos

Deng

et al. 2020

Journal of Periodontology

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Background The aim of this study is to compare the effects of icariin and teriparatide on the treatment of medication‐related osteonecrosis of the jaw (MRONJ) using a rat model. Methods Fifty rats undergoing ovariectomy were randomly assigned to control group (n = 10) and the MRONJ model group (n = 40). Zoledronic acid (0.2 mg/kg) and dexamethasone (2 mg/kg) were injected into rats in the model group for 8 weeks while saline was applied in control group, then all rats underwent tooth extraction and bone defect. Eight weeks later, rats diagnosed with MRONJ (n = 33) were randomly distributed to icariin (n = 11), teriparatide (n = 11), and the untreated (n = 11) group, and rats received daily 150 mg/kg icariin, 20 µg/kg teriparatide, and no intervention, respectively, for 8 weeks. Then, mandibulars were dissected for later examination. Results Rats diagnosed with MRONJ (33/40) demonstrated significantly larger area of soft tissue wound and necrotic bone with higher ratio of empty bone lacuna. Area of soft tissue wound and ratio of empty bone lacuna were significantly decreased in the icariin group compared with the untreated group, while teriparatide group revealed significantly higher ratio of receptor activator of NF‐kB ligand (RANKL)‐positive osteocytes, smaller area of necrotic bone and lower ratio of empty lacuna. The two agents were related to higher expression of BMP‐2 in osteocytes but were not statistically significant. Conclusions Icariin benefits MRONJ in terms of the area of soft tissue wound and ratio of empty lacuna. Teriparatide activates expression of RANKL and reduces the area of bone necrosis and ratio of empty lacuna in a MRONJ lesion. The data suggest possible healing improvement in patients with MRONJ and further studies to prove the efficacy of icariin.

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“…On the other hand, the current findings were not in agreement with other investigators whose findings revealed that the administration of dexamethasone may inhibit soft tissue healing 16 or delay extraction socket healing 29 . other researchers demonstrated that dexamethasone suppressed osteoblasts both in vivo and in vitro 9,10 .…”

Section: Discussionmentioning

confidence: 92%

Effect of Dexamethasone Infiltration on Periodontal Ligament After Experimental Molar Luxation in Rats

Hakam¹

2020

Egyptian Dental Journal

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Aim of the study:Dexamethasone is a popular corticosteroid in dental practice. Submucosal infiltration of dexamethasone proved to be effective to relief post-operative symptoms in different clinical and research application. This study was conducted to evaluate the effect of submucosal dexamethasone single injection on the healing of injured periodontal ligament fibers after molar luxation in rats via histological and gene expression studies. Materials and methods:24Wistar rats were selected for the study. Luxation injuries were performed for all first mandibular molars of both mandibular sides, right & left. Immediately after luxation, the right sides of the mandibles received submucosal injections of dexamethasone sodium phosphate (0.4mg/ml), while left sides were not dexamethasone injected. Follow up periods were 1, 3 & 7 days. Mandibular specimens were studied by routine histology, and quantitative gene expression analysis was done for fibroblast growth factor (FGF2), caspase-3 & alkaline phosphatase (ALP). Results:Histological features revealed superior results of the dexamethasone group with better regeneration and organization of fibers. Gene expression results revealed significant increase in the expression of both FGF2 and alkaline phosphatase (ALP) and a significant decrease in the expression of caspase-3 in the study side when compared to the control side.Conclusion: histologically dexamethasone enhanced the regeneration of torn periodontal ligament fibers with noticeable reduction in inflammation and rise in cellular proliferation. Gene expression reflected the possible benefit of dexamethasone single local injection in the management of periodontal ligament injuries.

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The effects of icariin on wound healing of extraction sites with administration of zoledronic and dexamethasone: A rat model study

Cited by 13 publications

References 26 publications

Icariin-mediated activation of autophagy confers protective effect on rotenone induced neurotoxicity in vivo and in vitro

Icariin-mediated activation of autophagy confers protective effect on rotenone induced neurotoxicity in vivo and in vitro

Management of medication‐related osteonecrosis of jaw: Comparison between icariin and teriparatide in a rat model

Effect of Dexamethasone Infiltration on Periodontal Ligament After Experimental Molar Luxation in Rats

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