The effects of<i>Permethrin</i>and antioxidant properties of<i>Allium cepa</i>(onion) on testicles parameters of male rats

Khaki, Arash; Rajabzadeh, Asghar

doi:10.1080/15569543.2016.1235582

Cited by 17 publications

(18 citation statements)

References 28 publications

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“…In the current study, evaluating the fertility power, it was found that pregnancy rate in TDOJ and OJ groups increased in comparison with the testicular torsion/detorsion group. In agreement with the results of the present study, khaki et al also reported that the use of onion juice could increase the concentration and motility of sperm and decrease the percentage of sperm with abnormal morphology (16,30,32).…”

Section: Discussionsupporting

confidence: 93%

“…It is suggested that antioxidant properties of onion juice and its compounds such as phenolic compositions and flavonoids can prevent overproduction of ROS (30). In the same vein, some studies reported that extract of onion could protect the testis tissue against oxidative damages induced by permethrin (16,30). Besides, Ige et al in their study showed that Allium cepa (AC) could protect the testis tissue against cadmium toxicity (31).…”

Section: Discussionmentioning

confidence: 99%

“…The quality of sperm such as the motility, count, and the percentage of normal morphological sperm increased as well. These phenomena may have occurred due to protective effects of onion juice against the damage of the Leydig cells (30). Similarly, one study indicated that onion juice had a positive impacts on the sexual hormones in rats treated with the antiepileptic drug.…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, the mean Johnson's score, the diameter of seminiferous tubules, and the thickness of the epithelium of seminiferous tubules in treated groups that received onion juice significantly increased as compared to the testicular torsion/detorsion group. It is suggested that antioxidant properties of onion juice and its compounds such as phenolic compositions and flavonoids can prevent overproduction of ROS (30). In the same vein, some studies reported that extract of onion could protect the testis tissue against oxidative damages induced by permethrin (16,30).…”

Section: Discussionmentioning

confidence: 99%

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Investigating the Effects of Onion Juice on Male Fertility Factors and Pregnancy Rate After Testicular Torsion/Detorsion by Intrauterine Insemination Method

Shokoohi¹,

Madarek²,

Khaki³

et al. 2018

International Journal of Women’s Health and Reproduction Scienc

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have mentioned that infertility in 30% to 80% of men was related to the high level of ROS (4,6,7). Oxidative stress (OS) was found to damage the reproductive system and sperm, and therefore result in reducing sperm motility, lipid peroxidation, and oocyte-sperm fusion in addition to increasing the DNA damage (4). ROS, as stated by several studies, had considerable effects on spermatogenesis and sperm function. They reported that overproduction of ROS had harmful effects on motility, morphology, and concentration of sperm and that it caused sperm DNA damage and apoptosis (4,7-9). Testicular torsion, which occurs due to rotation of testicles, is a pathologic condition that leads to acute scrotal pain. According to the reports, although testicular torsion can be observed in any age group, its peak incidence usually occurs in young males aged 13-16 years. Moreover, it is estimated that 4.5 per 100 000 males within the age range of 1-25 years suffer from spermatic cord torsion (10). Furthermore, as pointed out by some studies, the degree and duration of Abstract Objectives: In this experimental study, a testicular torsion/detorsion model was used in male rats to investigate the effect of onion juice on male fertility factors and rate of pregnancy by intrauterine insemination (IUI). Materials and Methods: A total of 56 Wistar rats (28 males vs. 28 females) were included in this study. Male rats were randomly divided into 4 groups including sham, testicular torsion/detorsion, testicular torsion/detorsion treated with onion juice (40 mg/kg, orally) 30 minutes before detorsion, and those rats that were only treated with onion juice. Treatment with onion juice was continued for 14 days after detorsion. At the end of the study, following anesthesia with ketamine/xylazine (5/1 mg/kg), levels of testosterone hormone as well as some oxidative stress markers in the blood serum of the male rats were analyzed. Furthermore, sperm parameters were assayed, and then fertility power of the male rats was investigated in the adult female rats using IUI method. Results: The results of the study showed that there was a significantly negative change in TD group in terms of histological parameters while they were decreased in treated groups. On the one hand, although serum level of malondialdehyde (MDA) significantly increased in TD group, other oxidative markers' (i.e., glutathione peroxidase and superoxide dismutase) serum levels and also testosterone hormone significantly decreased, on the other as compared to the other groups. In addition, the rate of sperm parameters and pregnancy presence were lower in TD group than those of other groups. However, onion juice as a treatment factor could improve the sperm quality and fertility power. Conclusions: The obtained results revealed that using onion juice could enhance the quality of sperm and fertility power after testicular torsion/detorsion.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Investigating the Effects of Onion Juice on Male Fertility Factors and Pregnancy Rate After Testicular Torsion/Detorsion by Intrauterine Insemination Method

Shokoohi¹,

Madarek²,

Khaki³

et al. 2018

International Journal of Women’s Health and Reproduction Scienc

Self Cite

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show abstract

“…[ 4 ] Since spermatogenesis takes place in the testis, any chemical agent like permethrin could be destroyed cellular structure and function and leads to infertility. [ 5 ] On the other hand, done studies for confronting these effects were mostly focused on reducing infertility rate and proposing the best way to treatment. Most studies represent a varied range of antioxidants to solving male infertility.…”

mentioning

confidence: 99%

Side Effects of Pyrethroid and Supporting Role of Onion in the Male Rat's Spermatogenesis

Khaki

Rajabzadeh

Khaki

2017

Chinese Medical Journal

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Probabilistic risk assessment (Monte Carlo simulation method) of Pb and Cd in the onion bulb (Allium cepa) and soil of Iran

Fakhri

Khaneghah

Conti

et al. 2018

Environ Sci Pollut Res

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Recently, the exposure to heavy metals through the consumption of vegetables has become a global concern. In this regard, the current study was aimed to measure the concentrations of lead (Pb) and cadmium (Cd) in the collected onion bulb samples as well as the surrounded soil using a flame atomic absorption spectrometer (FAAS). Additionally, the target hazard quotient (THQ) for males and females in all age groups of consumers were estimated by using Monte Carlo Simulation (MCS) method. Furthermore, the soil threshold values (STVs) were evaluated to investigate the heavy metal contents in the soil based on the established standard limits. In this context, 45 onion bulbs (HashtBandi region, 25 and Ravang region, 20) and 41 soil (HashtBandi region, 21 and Ravang region, 20) samples were collected (March-May of 2016). The average concentrations of Pb in the onions from HashtBandi and Ravang regions were determined as 0.0052 ± 0.0011 and 0.0061 ± 0.0022 mg/kg, and for Cd were 0.0095 ± 0.0024 and 0.0011 ± 0.0035 mg/kg, respectively. The average concentration of Pb in the soil from HashtBandi and Ravang regions were measured as 3.99 ± 3.77 and 2.03 ± 0.69 mg/kg, and for Cd, the corresponding values were determined as 2.21 ± 3.17 and 2.22 ± 0.92 mg/kg, respectively. The average concentration of Pb and Cd in both investigated onion bulb and soil were lower than Iranian national (onion bulb: Pb = 0.1 mg/kg, Cd = 0.05 mg/kg) and FAO/WHO (onion bulb: Pb = 0.3 mg/kg, Cd = 0.1 mg/kg; soil: Pb = 50 mg/kg, Cd = 0.3 mg/kg) standard limits. Moreover, the THQ and total target hazard quotient (TTHQ) for males and females in all age groups were less than 1 value. Therefore, no risk of the exposure to Pb and Cd as result of onion bulb consumption was reported. STVs for Pb and Cd in the HashtBandi region were calculated as 3.99 and 2.21 mg/kg, and Ravang as 2.03 and 2.22 mg/kg, respectively. Due to the higher calculated STVs for Cd while compared with the established standard limit for the soil, the further revisions regarding the heavy metal standard limits in the soil were recommended.

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The effects ofPermethrinand antioxidant properties ofAllium cepa(onion) on testicles parameters of male rats

Cited by 17 publications

References 28 publications

Investigating the Effects of Onion Juice on Male Fertility Factors and Pregnancy Rate After Testicular Torsion/Detorsion by Intrauterine Insemination Method

Investigating the Effects of Onion Juice on Male Fertility Factors and Pregnancy Rate After Testicular Torsion/Detorsion by Intrauterine Insemination Method

Side Effects of Pyrethroid and Supporting Role of Onion in the Male Rat's Spermatogenesis

Probabilistic risk assessment (Monte Carlo simulation method) of Pb and Cd in the onion bulb (Allium cepa) and soil of Iran

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