Side Effects of Pyrethroid and Supporting Role of Onion in the Male Rat's Spermatogenesis

Khaki, Arash; Rajabzadeh, Asghar; Khaki, Amir Afshin

doi:10.4103/0366-6999.220297

Cited by 7 publications

(7 citation statements)

References 8 publications

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“…In the current study, evaluating the fertility power, it was found that pregnancy rate in TDOJ and OJ groups increased in comparison with the testicular torsion/detorsion group. In agreement with the results of the present study, khaki et al also reported that the use of onion juice could increase the concentration and motility of sperm and decrease the percentage of sperm with abnormal morphology (16,30,32).…”

Section: Discussionsupporting

confidence: 93%

“…It is suggested that antioxidant properties of onion juice and its compounds such as phenolic compositions and flavonoids can prevent overproduction of ROS (30). In the same vein, some studies reported that extract of onion could protect the testis tissue against oxidative damages induced by permethrin (16,30). Besides, Ige et al in their study showed that Allium cepa (AC) could protect the testis tissue against cadmium toxicity (31).…”

Section: Discussionmentioning

confidence: 99%

“…The extract of onion protects sperm against DNA damage and other important molecules related to OS. It also improves sperm quality and enhances the power of fertility (16). Hence, the present study aimed to evaluate the effect of onion juice on rate of male fertility and sperm quality after testicular torsion/detorsion by intrauterine insemination (IUI) in adult female rats.…”

Section: Mortalities and Morbiditiesmentioning

confidence: 99%

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Investigating the Effects of Onion Juice on Male Fertility Factors and Pregnancy Rate After Testicular Torsion/Detorsion by Intrauterine Insemination Method

Shokoohi¹,

Madarek²,

Khaki³

et al. 2018

International Journal of Women’s Health and Reproduction Scienc

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have mentioned that infertility in 30% to 80% of men was related to the high level of ROS (4,6,7). Oxidative stress (OS) was found to damage the reproductive system and sperm, and therefore result in reducing sperm motility, lipid peroxidation, and oocyte-sperm fusion in addition to increasing the DNA damage (4). ROS, as stated by several studies, had considerable effects on spermatogenesis and sperm function. They reported that overproduction of ROS had harmful effects on motility, morphology, and concentration of sperm and that it caused sperm DNA damage and apoptosis (4,7-9). Testicular torsion, which occurs due to rotation of testicles, is a pathologic condition that leads to acute scrotal pain. According to the reports, although testicular torsion can be observed in any age group, its peak incidence usually occurs in young males aged 13-16 years. Moreover, it is estimated that 4.5 per 100 000 males within the age range of 1-25 years suffer from spermatic cord torsion (10). Furthermore, as pointed out by some studies, the degree and duration of Abstract Objectives: In this experimental study, a testicular torsion/detorsion model was used in male rats to investigate the effect of onion juice on male fertility factors and rate of pregnancy by intrauterine insemination (IUI). Materials and Methods: A total of 56 Wistar rats (28 males vs. 28 females) were included in this study. Male rats were randomly divided into 4 groups including sham, testicular torsion/detorsion, testicular torsion/detorsion treated with onion juice (40 mg/kg, orally) 30 minutes before detorsion, and those rats that were only treated with onion juice. Treatment with onion juice was continued for 14 days after detorsion. At the end of the study, following anesthesia with ketamine/xylazine (5/1 mg/kg), levels of testosterone hormone as well as some oxidative stress markers in the blood serum of the male rats were analyzed. Furthermore, sperm parameters were assayed, and then fertility power of the male rats was investigated in the adult female rats using IUI method. Results: The results of the study showed that there was a significantly negative change in TD group in terms of histological parameters while they were decreased in treated groups. On the one hand, although serum level of malondialdehyde (MDA) significantly increased in TD group, other oxidative markers' (i.e., glutathione peroxidase and superoxide dismutase) serum levels and also testosterone hormone significantly decreased, on the other as compared to the other groups. In addition, the rate of sperm parameters and pregnancy presence were lower in TD group than those of other groups. However, onion juice as a treatment factor could improve the sperm quality and fertility power. Conclusions: The obtained results revealed that using onion juice could enhance the quality of sperm and fertility power after testicular torsion/detorsion.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Mortalities and Morbiditiesmentioning

confidence: 99%

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Investigating the Effects of Onion Juice on Male Fertility Factors and Pregnancy Rate After Testicular Torsion/Detorsion by Intrauterine Insemination Method

Shokoohi¹,

Madarek²,

Khaki³

et al. 2018

International Journal of Women’s Health and Reproduction Scienc

Self Cite

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show abstract

“…Infertility has been considered a public health problem. Studies have shown that onion exhibited protective effects against adverse effects of chemical toxicity (119)(120)(121)(122) and bacterial infection (118) on reproductive system, and could improve fertility and the quality of sperm and egg (15,126).…”

Section: Reproductive System Protectionmentioning

confidence: 99%

“…Besides, onion could restore the permethrin-induced reductions in hormonal levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) as well as the expression of some key genes, such as luteinizing hormone/choriogonadotropin receptor (LHCGR) and steroidogenic factor 1 (SF1) (121). Onion also showed protective effects on testicle parameters and spermatogenesis in rats against the destructive effects of some insecticides or herbicides, such as permethrin, pyrethroid and paraquat (119,120,122). Onion seed extract was reported to have a protective activity against the negative effects of diabetes on the reproductive system in STZ-induced diabetic rats (77).…”

Section: Reproductive System Protectionmentioning

confidence: 99%

Recent Advances in Bioactive Compounds, Health Functions, and Safety Concerns of Onion (Allium cepa L.)

Zhao

Lin

et al. 2021

Front. Nutr.

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Onion (Allium cepa L.) is a common vegetable, widely consumed all over the world. Onion contains diverse phytochemicals, including organosulfur compounds, phenolic compounds, polysaccharides, and saponins. The phenolic and sulfur-containing compounds, including onionin A, cysteine sulfoxides, quercetin, and quercetin glucosides, are the major bioactive constituents of onion. Accumulated studies have revealed that onion and its bioactive compounds possess various health functions, such as antioxidant, antimicrobial, anti-inflammatory, anti-obesity, anti-diabetic, anticancer, cardiovascular protective, neuroprotective, hepatorenal protective, respiratory protective, digestive system protective, reproductive protective, and immunomodulatory properties. Herein, the main bioactive compounds in onion are summarized, followed by intensively discussing its major health functions as well as relevant molecular mechanisms. Moreover, the potential safety concerns about onion contamination and the ways to mitigate these issues are also discussed. We hope that this paper can attract broader attention to onion and its bioactive compounds, which are promising ingredients in the development of functional foods and nutraceuticals for preventing and managing certain chronic diseases.

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Targeting ERK/COX-2 signaling pathway in permethrin-induced testicular toxicity: a possible modulating effect of matrine

et al. 2019

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Side Effects of Pyrethroid and Supporting Role of Onion in the Male Rat's Spermatogenesis

Cited by 7 publications

References 8 publications

Investigating the Effects of Onion Juice on Male Fertility Factors and Pregnancy Rate After Testicular Torsion/Detorsion by Intrauterine Insemination Method

Investigating the Effects of Onion Juice on Male Fertility Factors and Pregnancy Rate After Testicular Torsion/Detorsion by Intrauterine Insemination Method

Recent Advances in Bioactive Compounds, Health Functions, and Safety Concerns of Onion (Allium cepa L.)

Targeting ERK/COX-2 signaling pathway in permethrin-induced testicular toxicity: a possible modulating effect of matrine

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