The effects of hematological parameters and tumor-infiltrating lymphocytes on prognosis in patients with gastric cancer

Abstract

The results suggest that the elevated NLR predicts poor overall survival following at the time diagnosis for all stage gastric cancer. dNLR was not independently associated with overall survival. There is insufficient evidence to the assesment of TIL by a nonspesific method. Therefore further studies is required, to confirm our hypothesis in larger patient cohorts.

Prognostic Significance of Neutrophil Lymphocyte Ratio in Patients with Gastric Cancer: A Meta-Analysis

“…Three studies were excluded as HR can't be calculated by the described method [19] – [21] and 2 studies were excluded as failed to present NLR specific data for OS or DFS and PFS [22] – [23] . A total of 10 articles [13] – [14] , [24] – [31] that met the inclusion and exclusion criteria were retrieved. Of these reports selected for further evaluation, 10 investigated the prognostic role of NLR for OS, 3 for DFS and 2 for PFS, respectively.…”

Association of intra‐tumoral tumour‐infiltrating lymphocytes and neutrophil‐to‐lymphocyte ratio is an independent prognostic factor in non‐small cell lung cancer

“…Similarly, increased TILs have been associated with longer survival in NSCLC . However, the non‐specific lymphocyte density in tumour tissue was not significantly correlated with overall survival (OS) in patients with cancer .…”

The clinical significance of hematologic parameters in patients with sarcoidosis

“…Leukocyte count and its subtypes are also well‐known inflammatory markers . In recent years, there have been some studies investigating the potential role of leukocyte subtype ratios during the inflammatory process of chronic diseases . The ratio of absolute neutrophil count to lymphocyte count [neutrophil‐to‐lymphocyte ratio (NLR)] was introduced as a cost‐effective potential inflammatory marker that has prognostic and predictive values in systemic inflammatory diseases and cancer .…”