The clinical significance of hematologic parameters in patients with sarcoidosis

Dirican, Nigar; Anar, Ceyda; Kaya, Şule; Bircan, Hacı Ahmet; Colar, Huseyin Halil; Çakır, Münire

doi:10.1111/crj.12178

“…In a Turkish study that compared sarcoidosis and control groups, neutrophil count, NLR and CRP were significantly higher, and lymphocytes were significantly lower in the sarcoidosis group [20]. Additionally, Dirican et al [21] concluded that a higher NLR (≥2) was detected in patients with sarcoidosis and that this was more frequent in patients with extrapulmonary involvement. We assessed whether NLR varied with age in our cohort but did not find a significant difference between the groups.…”

Section: Discussionmentioning

confidence: 97%

Analysis of Age Distribution and Disease Presentation of 1269 Patients with Sarcoidosis

Koçak

¹

,

Güngör

²

,

Aktürk

³

et al. 2017

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Objective: While the incidence of sarcoidosis peaks between 20 and 39 years, it is comparatively low in elderly subjects. We sought to determine whether there are age-dependent differences in the demographic and laboratory characteristics of patients with sarcoidosis. Materials and Methods: We retrospectively collected information from our database using the International Classification of Disease (ICD) diagnostic code D86 between 2008 and 2014. Patients were divided into three groups: 20-39 years old (Group 1), 40-59 years old (Group 2), and 60-80 years old (Group 3). Results: A total of 3988 patients with code of D86 were included in the study. After the exclusion of noneligible patients, the number of cases in Groups 1, 2, and 3 were 276, 641, and 352, respectively. The groups were compared according to demographic characteristics, ICD diagnostic codes, and laboratory parameters. The ratio of female patients was significantly higher in Group 3 than in Groups 1 and 2 (p=0.000). There was no difference in diagnostic codes of the ICD subgroups between groups (p=0.19). While the level of bloodurea nitrogen was significantly higher in Group 3 patients than in other groups (p=0.000), serum angiotensinconverting enzyme (ACE) values were found to be significantly low in Group 3 (p=0.010). The mean ACE values did not differ between females and males (50.8±39.3 and 59.1±45.5 mg/dL, respectively) (p=0.18). Conclusion:The majority of patients with sarcoidosis were female in all age groups and pulmonary sarcoidosis was the most common presentation of the disease. Elderly patients (≥60 years) with sarcoidosis had lower serum ACE levels than younger patients.

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“…Recently, NLR has been recognized as a simple and cost-effective peripheral biomarker that indicates the inflammatory status because it is believed to reflect the numerical balance between neutrophils and lymphocytes in the blood (9,10,15,16). CRP and ESR are elevated in the event of systemic inflammation, and combined use of ESR and CRP was considered to be more appropriate as inflammatory markers (17).…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies demonstrated that NLR can be used as a marker of disease, but it may also predict the disease severity and a poor prognosis (9,10,11,15,19). Similarly, positive correlations were found among the initial NLR, the initial Hughes scores, and the length of hospital stay.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Significance of the Neutrophil-to-Lymphocyte Ratio in Patients with Guillain-Barré Syndrome Independent of Infection

Geyik

¹

,

Bozkurt

²

,

Neyal

³

et al. 2016

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“…The NLR has emerged as a new marker of inflammation [20,21]. It can be easily calculated from a routine complete blood count and is determined by dividing the absolute neutrophil count by the number of lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

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2017

Eurasian J Med

1

0

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Objective: While the incidence of sarcoidosis peaks between 20 and 39 years, it is comparatively low in elderly subjects. We sought to determine whether there are age-dependent differences in the demographic and laboratory characteristics of patients with sarcoidosis. Materials and Methods: We retrospectively collected information from our database using the International Classification of Disease (ICD) diagnostic code D86 between 2008 and 2014. Patients were divided into three groups: 20-39 years old (Group 1), 40-59 years old (Group 2), and 60-80 years old (Group 3). Results: A total of 3988 patients with code of D86 were included in the study. After the exclusion of noneligible patients, the number of cases in Groups 1, 2, and 3 were 276, 641, and 352, respectively. The groups were compared according to demographic characteristics, ICD diagnostic codes, and laboratory parameters. The ratio of female patients was significantly higher in Group 3 than in Groups 1 and 2 (p=0.000). There was no difference in diagnostic codes of the ICD subgroups between groups (p=0.19). While the level of bloodurea nitrogen was significantly higher in Group 3 patients than in other groups (p=0.000), serum angiotensinconverting enzyme (ACE) values were found to be significantly low in Group 3 (p=0.010). The mean ACE values did not differ between females and males (50.8±39.3 and 59.1±45.5 mg/dL, respectively) (p=0.18). Conclusion:The majority of patients with sarcoidosis were female in all age groups and pulmonary sarcoidosis was the most common presentation of the disease. Elderly patients (≥60 years) with sarcoidosis had lower serum ACE levels than younger patients.

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The clinical significance of hematologic parameters in patients with sarcoidosis

Abstract: NLR may be a biomarker with good sensitivity that is easily detected in serum. It can be proposed in clinical practice to identify a patient's prognosis. However, large prospective studies are required to further demonstrate the prognostic significance of these values.

Cited by 36 publications

References 28 publications

Analysis of Age Distribution and Disease Presentation of 1269 Patients with Sarcoidosis

Analysis of Age Distribution and Disease Presentation of 1269 Patients with Sarcoidosis

The Clinical Significance of the Neutrophil-to-Lymphocyte Ratio in Patients with Guillain-Barré Syndrome Independent of Infection

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