Association of intra‐tumoral tumour‐infiltrating lymphocytes and neutrophil‐to‐lymphocyte ratio is an independent prognostic factor in non‐small cell lung cancer

Dirican, Nigar; Karakaya, Yeliz Arman; Gunes, Sedat; Daloglu, Ferah Tuncel; Dirican, Ahmet

doi:10.1111/crj.12417

Cited by 38 publications

(29 citation statements)

References 26 publications

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“…Previous studies have reported an association between inflammatory parameters and local immune response . In patients with non‐small‐cell lung cancer, a high NLR was negatively correlated with intratumoural CD3 + TILs .…”

Section: Discussionmentioning

confidence: 80%

“…Previous studies have reported an association between inflammatory parameters and local immune response. [23][24][25] In patients with non-small-cell lung cancer, a high NLR was negatively correlated with intratumoural CD3 + TILs. 23 However, in patients with laryngeal SCC, the PLR and TIL density were prognostic factors for systemic and local inflammation, but there were no significant correlations between NLR or PLR, and TIL density.…”

Section: Discussionmentioning

confidence: 98%

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Pre‐treatment CD8⁺ tumour‐infiltrating lymphocyte density predicts distant metastasis after definitive treatment in patients with stage III/IV hypopharyngeal squamous cell carcinoma

Ono

Azuma

Kawahara

et al. 2018

Clinical Otolaryngology

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 98%

Pre‐treatment CD8⁺ tumour‐infiltrating lymphocyte density predicts distant metastasis after definitive treatment in patients with stage III/IV hypopharyngeal squamous cell carcinoma

Ono

Azuma

Kawahara

et al. 2018

Clinical Otolaryngology

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“…Further studies are needed to investigate the predictive role of NLR for brain metastases in NSCLC with or without EGFR mutation and the association between NLR and EGFR mutation. Second, there have been many previous studies evaluating the prognostic role of NLR in patients with NSCLC18194243. However, a well-established cutoff for NLR was not identified due to diverse study populations and various selection methods.…”

Section: Discussionmentioning

confidence: 99%

Baseline neutrophil–lymphocyte ratio is associated with baseline and subsequent presence of brain metastases in advanced non-small-cell lung cancer

Koh

Choi

Ahn

et al. 2016

Sci Rep

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We examined the predictive value of neutrophil–lymphocyte ratio (NLR) by examining their association with the baseline presence and subsequent development of brain metastases in patients with stage IV non-small cell lung cancer (NSCLC). We examined the predictive value of NLR for brain metastasis in 260 stage IV NSCLC. Logistic regression models and competing risk analysis were used to determine the association of NLR with baseline and subsequent presence of brain metastases. Multivariate analysis reveals that patients with high NLR (≥4.95) had significantly more brain metastases at diagnosis than those with low NLR (Odds Ratio = 2.59, P = 0.01). In patients who had no baseline brain metastasis, competing risks analysis revealed that patients with high NLR showed higher cumulative incidence of subsequent brain metastases, compared to those with low NLR (P = 0.017). A high NLR was associated with the baseline presence or the subsequent development of brain metastases, particularly in the group with adenocarcinoma (P = 0.013 and P = 0.044, respectively). Furthermore, an increase in NLR during treatment was associated with subsequent brain metastases (P = 0.004). The NLR is an independent predictive factor for the baseline presence of brain metastases and subsequent brain metastases in stage IV NSCLC.

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“…5 The neutrophil-to-lymphocyte ratio (NLR) has recently been shown to predict overall and disease-specific mortality and chemotherapy response in cancer patients. 6–8 NLR is also shown to be associated with complexity of peripheral arterial disease, 9 systemic endothelial dysfunction, 10 and cardiovascular diseases. 11 No study has investigated the predicting value of NLR for wound healing outcome in diabetic foot ulcers.…”

mentioning

confidence: 99%

Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing

Vatankhah

Jahangiri

Landry

et al. 2017

Journal of Vascular Surgery

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Objective The neutrophil-to-lymphocyte ratio (NLR) has been used as a surrogate marker of systemic inflammation. We sought to investigate the association between NLR and wound healing in diabetic wounds. Methods The outcomes of 120 diabetic foot ulcers in 101 patients referred from August 2011 to December 2014 were examined retrospectively. Demographic, patient-specific, and wound-specific variables as well as NLR at baseline visit were assessed. Outcomes were classified as ulcer healing, minor amputation, major amputation, and chronic ulcer. Results The subjects’ mean age was 59.4 ± 13.0 years, and 67 (66%) were male. Final outcome was complete healing in 24 ulcers (20%), minor amputation in 58 (48%) and major amputation in 16 (13%), and 22 chronic ulcers (18%) at the last follow-up (median follow-up time, 6.8 months). In multivariate analysis, higher NLR (odds ratio, 13.61; P = .01) was associated with higher odds of nonhealing. Conclusions NLR can predict odds of complete healing in diabetic foot ulcers independent of wound infection and other factors.

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Association of intra‐tumoral tumour‐infiltrating lymphocytes and neutrophil‐to‐lymphocyte ratio is an independent prognostic factor in non‐small cell lung cancer

Cited by 38 publications

References 26 publications

Pre‐treatment CD8⁺ tumour‐infiltrating lymphocyte density predicts distant metastasis after definitive treatment in patients with stage III/IV hypopharyngeal squamous cell carcinoma

Pre‐treatment CD8⁺ tumour‐infiltrating lymphocyte density predicts distant metastasis after definitive treatment in patients with stage III/IV hypopharyngeal squamous cell carcinoma

Baseline neutrophil–lymphocyte ratio is associated with baseline and subsequent presence of brain metastases in advanced non-small-cell lung cancer

Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing

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Association of intra‐tumoral tumour‐infiltrating lymphocytes and neutrophil‐to‐lymphocyte ratio is an independent prognostic factor in non‐small cell lung cancer

Cited by 38 publications

References 26 publications

Pre‐treatment CD8+ tumour‐infiltrating lymphocyte density predicts distant metastasis after definitive treatment in patients with stage III/IV hypopharyngeal squamous cell carcinoma

Pre‐treatment CD8+ tumour‐infiltrating lymphocyte density predicts distant metastasis after definitive treatment in patients with stage III/IV hypopharyngeal squamous cell carcinoma

Baseline neutrophil–lymphocyte ratio is associated with baseline and subsequent presence of brain metastases in advanced non-small-cell lung cancer

Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing

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Pre‐treatment CD8⁺ tumour‐infiltrating lymphocyte density predicts distant metastasis after definitive treatment in patients with stage III/IV hypopharyngeal squamous cell carcinoma

Pre‐treatment CD8⁺ tumour‐infiltrating lymphocyte density predicts distant metastasis after definitive treatment in patients with stage III/IV hypopharyngeal squamous cell carcinoma