The Effects of Heliotropium Ovalifolium on Goats and Sheep

Damir, Hassen Abu; Adam, Safwaan; Tartour, G.

doi:10.1016/s0007-1935(17)30931-4

Cited by 27 publications

(35 citation statements)

References 10 publications

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“…These cellular changes were similar to those reported previously in cattle, 16 goats, 7,13,19 sheep, 33 and ponies 25 poisoned by S. carpinifolia. Similar lesions were also reported in cases of poisoning by plants that contain the alkaloid swainsonine, 1,3,4,9,10,12,20,22 as well as in cases of inherited alpha-mannosidosis in cattle, 21,39 humans, 29 domestic cats, 5,27 and the guinea pig. 28 As in the inherited disease, in the acquired form of alpha-mannosidosis, the alkaloid swainsonine inhibits lysosomal enzyme alpha-mannosidase, 6,8,11,14 resulting in the storage and excretion of partially impaired oligosaccharides.…”

Section: Discussionsupporting

confidence: 69%

Spontaneous Lysosomal Storage Disease Caused by Sida carpinifolia (Malvaceae) Poisoning in Cattle

Furlan

Lucioli

Veronezi

et al. 2009

Veterinary Pathology

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Abstract. Clinical and pathologic findings for the spontaneous poisoning by Sida carpinifolia in cattle are described in this study. A survey on field cases of S. carpinifolia in cattle was carried out on farms of Alto Vale do Itajaí, State of Santa Catarina, southern Brazil. Sixteen affected animals were clinically evaluated and 9 were subjected to postmortem examination. The main clinical signs consisted of marching gait, alert gaze, head tremors, and poor growth. Histologic and ultrastructural lesions consisted of vacuolization and distension of neuronal perikarya, mainly from Purkinje cells, and of the cytoplasm of acinar pancreatic and thyroid follicular cells. Clinical signs and lesions varied from mild to severe. Improvement of the clinical signs was observed in cattle after a period of up to 90 days without consuming the plant; however, residual lesions, mainly characterized by axonal spheroids and absence of Purkinje neurons in some areas of the cerebellum, were observed in these cases. It is concluded that the natural chronic consumption of S. carpinifolia was the etiologic cause of storage disease in cattle in this study.

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Section: Discussionsupporting

confidence: 69%

Spontaneous Lysosomal Storage Disease Caused by Sida carpinifolia (Malvaceae) Poisoning in Cattle

Furlan

Lucioli

Veronezi

et al. 2009

Veterinary Pathology

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“…Despite many reports on the poisoning of Ipomoea carnea, clinical signs and morphological lesions of poisoning have not been well characterized , Tartour et al 1974, Damir et al 1987, Nath & Pathak 1995, Schumaher-Henrique et al 2003.The aim of this paper is to describe the epidemiology, clinical signs and pathology of the experimental poisoning by Ipomoea carnea subsp. ϔistulosa primarily affecting the CNS of goats.…”

Section: Introductionmentioning

confidence: 95%

“…has been held responsible for severe episodes of intoxication in the tropics and subtropics. There are reports of spontaneous poisoning, especially in goats, in parts of Brazil, Sudan, India, Mozambique and Argentina (Damir et al 1987, De Balogh et al 1999, Rodriguez Armesto et al 2004, Barbosa et al2006, Antoniassi et al 2007, Armien et al 2007, Barbosa et al 2007, Ríos et al 2008). The plant contains as main toxic component swainsonine which inhibits lysosomal enzyme α-mannosidase and mannosidase II Golgi apparatus (Colegate et al 1979, Molyneux & James 1982.…”

Section: Introductionmentioning

confidence: 98%

Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina: a clinic and pathological correlation with special consideration on the central nervous system

et al. 2012

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Ipomoea carnea subsp. fistulosa, aguapei or mandiyura, is responsible for lysosomal storage in goats. The shrub contains several alkaloids, mainly swansonine which inhibits lysosomal α-mannosidase and Golgi mannosidase II. Poisoning occurs by inhibition of these hydrolases. There is neuronal vacuolation, endocrine dysfunction, cardiovascular and gastrointestinal injury, and immune disorders. Clinical signs and pathology of the experimental poisoning of goats by Ipomoea carnea in Argentina are here described. Five goats received fresh leaves and stems of Ipomoea. At the beginning, the goats did not consume the plant, but later, it was preferred over any other forage. High dose induced rapid intoxication, whereas with low doses, the course of the toxicosis was more protracted. The goats were euthanized when they were recumbent. Cerebrum, cerebellum, medulla oblongata, pons and colliculi, were routinely processed for histology. In nine days, the following clinical signs developed: abnormal fascies, dilated nostrils and abnormal postures of the head, cephalic tremors and nystagmus, difficulty in standing. Subsequently, the goats had a tendency to fall, always to the left, with spastic convulsions. There was lack in coordination of voluntary movements due to Purkinje and deep nuclei neurons damage. The cochlear reflex originated hyperreflexia, abnormal posture, head movements and tremors. The withdrawal reflex produced flexor muscles hypersensitivity at the four legs, later depression and stupor. Abnormal responses to sounds were related to collicular lesions. Thalamic damage altered the withdrawal reflex, showing incomplete reaction. The observed cervical hair bristling was attributed to a thalamic regulated nociceptive response. Depression may be associated with agonists of lysergic acid contained in Ipomoea. These clinical signs were correlated with lesions in different parts of the CNS.

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“…na Austrália (Colegate et al 1979), Ipomoea spp. no Sudão (Damir et al 1987), Moçambique (Balogh et al 1999), Argentina (Armesto et al 2004, Ríos et al 2008 e Brasil (Barbosa et al 2006, Antoniassi et al 2007, Armién et al 2007, Barbosa et al 2007, além de Turbina cordata, também no Brasil (Dantas et al 2006). Este trabalho relata a ocorrência da intoxicação por Sida carpinifolia (Malvaceae) em bovinos no Rio Grande do Sul e descreve os achados epidemiológicos, clínico-patológicos, lectina-histoquímicos e ultraestruturais associados com a doença.…”

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Doença do armazenamento lisossomal induzida pelo consumo de Sida carpinifolia em bovinos do Rio Grande do Sul

et al. 2010

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The Effects of Heliotropium Ovalifolium on Goats and Sheep

Cited by 27 publications

References 10 publications

Spontaneous Lysosomal Storage Disease Caused by Sida carpinifolia (Malvaceae) Poisoning in Cattle

Spontaneous Lysosomal Storage Disease Caused by Sida carpinifolia (Malvaceae) Poisoning in Cattle

Experimental poisoning of goats by Ipomoea carnea subsp. fistulosa in Argentina: a clinic and pathological correlation with special consideration on the central nervous system

Doença do armazenamento lisossomal induzida pelo consumo de Sida carpinifolia em bovinos do Rio Grande do Sul

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