“…The biological mechanism involves changes in metabolism and the function of several biomarkers such as serotonin (Wipfli et al, 2011), beta-endorphins (Dishman andO'Connor, 2009, Heyman et al, 2012) endocannabinoids (Dietrich andMcDaniel, 2004, Heyman, Gamelin, 2012), brain-derived neurotrophic factor (BDNF) (Gustafsson et al, 2009, Laske et al, 2010, Schuch et al, 2014, Toups et al, 2011 oxidative stress, and inflammation Baune, 2012, Eyre et al, 2013). Genetic pathways, such as pleiotropy or gene-by-exercise interactions, also appear to be possible explanations related to the antidepressant effects of exercise (de Geus and de Moor, 2008).…”